Fluorapatite ceramics for bone tissue regeneration: Synthesis, characterization and assessment of biomedical potential

Borkowski, Leszek; Przekora, Agata; Belcarz, Anna; Pałka, K.; Józefaciuk, Grzegorz; Lübek, Tomasz; Jojczuk, Mariusz; Nogalski, Adam; Ginalska, Grażyna

doi:10.1016/j.msec.2020.111211

Cited by 43 publications

(47 citation statements)

References 37 publications

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“…In the present day, the advance of science remains fast-paced, especially in disciplines associated with medicine and human life. The need to save human lives, relieve pain, reconstruct parts of the human body after injuries, and, finally, cure those suffering from various kinds of local or systemic ailments using traditional methods [ 1 ] are the flywheels of progress both in medicine itself and many other disciplines that are subsidiary to medicine in terms of their classification, but which share its goals, such as material engineering and, in particular, the development of biomaterials [ 2 , 3 , 4 ]. Some biomaterials used to aid patients are bone cements.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Contaminating Poly (Methyl Methacrylate) (PMMA) Bone Cements on Their Compressive Strength

et al. 2021

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This study presents an analysis of the impact of doping bone cement with saline. The two-ingredient cement, made right before the surgery, is subject to various kinds of organic contaminants and liquids used in the operating area, such as saline used to cleanse or cool it, during the process of mounting the prosthesis or bone-filling procedures. The processes of experimental destructive testing and statistical analysis have shown that, depending on the degree of saline doping, the static compressive strength parameters may greatly improve (with a low degree of contamination) or significantly worsen (when the contamination degree is higher). The limit value of the degree of salt admixture was estimated (2%), with which no statistically significant differences were observed in the cement strength in relation to the strength of non-contaminated cement.

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Section: Introductionmentioning

confidence: 99%

The Impact of Contaminating Poly (Methyl Methacrylate) (PMMA) Bone Cements on Their Compressive Strength

et al. 2021

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“…Bands at 963 cm −1 , 1025-1032 cm −1 and 1088 cm −1 , indicating the presence of phosphate groups, are visible in spectra of both composites and granules. Moreover, band at 746 cm −1 (indicating the presence of F − ions) in spectrum of FAP granules is present also in the spectrum of FAP/glucan composite [ 31 ]. Bands of C 1 -O-C 3 stretching vibrations at 887 cm −1 and 1157 cm −1 (characteristic for β-glucan) are found in spectra of both glucan and the composites, confirming the presence of curdlan in created biomaterials.…”

Section: Resultsmentioning

confidence: 99%

“…This feature is most probably related to the properties of fluorapatite, the main compound of the composite. It was reported that bulk density and porosity of FAP granules are 0.75 g/cm 3 and 52% in comparison with 0.55 g/cm 3 and 64% for HAP granules [ 31 ]. Volume of intrinsic pores in FAP and HAP granules was 0.36 cm 3 /g and 0.58 cm 3 /g, respectively [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…It was reported that bulk density and porosity of FAP granules are 0.75 g/cm 3 and 52% in comparison with 0.55 g/cm 3 and 64% for HAP granules [ 31 ]. Volume of intrinsic pores in FAP and HAP granules was 0.36 cm 3 /g and 0.58 cm 3 /g, respectively [ 31 ]. Relation between the density and fluoride content in ceramics was also reported by Gross et al [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

“…235803 [ 30 ]. Our previous research showed that the modified sol-gel method allowed for the successful introduction of fluoride ions into the structure of the apatite network, and the obtained fluorapatite, after calcination at 800 °C, was characterized by a gradual release of F − at a level appropriate for the osteoblast cell line and supporting osteoblast proliferation [ 31 ]. Therefore, FAP has been used in our present work to prepare a ceramic-polymer FAP/glucan composite material with properties, which would potentially support regeneration of bone tissue.…”

Section: Introductionmentioning

confidence: 99%

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Highly Porous Fluorapatite/β-1,3-Glucan Composite for Bone Tissue Regeneration: Characterization and In-Vitro Assessment of Biomedical Potential

Borkowski

Przekora

Belcarz

et al. 2021

IJMS

Self Cite

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A novel fluorapatite/glucan composite (“FAP/glucan”) was developed for the treatment of bone defects. Due to the presence of polysaccharide polymer (β-1,3-glucan), the composite is highly flexible and thus very convenient for surgery. Its physicochemical and microstructural properties were evaluated using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), mercury intrusion, mechanical testing and compared with the reference material, which was a hydroxyapatite/glucan composite (“HAP/glucan”) with hydroxyapatite granules (HAP) instead of FAP. It was found that FAP/glucan has a higher density and lower porosity than the reference material. The correlation between the Young’s modulus and the compressive strength between the materials is different in a dry and wet state. Bioactivity assessment showed a lower ability to form apatite and lower uptake of apatite-forming ions from the simulated body fluid by FAP/glucan material in comparison to the reference material. Moreover, FAP/glucan was determined to be of optimal fluoride release capacity for osteoblasts growth requirements. The results of cell culture experiments showed that fluoride-containing biomaterial was non-toxic, enhanced the synthesis of osteocalcin and stimulated the adhesion of osteogenic cells.

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Sintered fluorapatite scaffolds as an autograft‐like engineered bone graft

Nielson,

Agarwal,

Beck

et al. 2024

J Biomed Mater Res

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Hydroxyapatite (HA)‐based materials are widely used as bone substitutes due to their inherent biocompatibility, osteoconductivity, and bio‐absorption properties. However, HA scaffolds lack compressive strength when compared to autograft bone. It has been shown that the fluoridated form of HA, fluorapatite (FA), can be sintered to obtain this desired strength as well as slower degradation properties. Also, FA surfaces have been previously shown to promote stem cell differentiation toward an osteogenic lineage. Thus, it was hypothesized that FA, with and without stromal vascular fraction (SVF), would guide bone healing to an equal or better extent than the clinical gold standard. The regenerative potentials of these scaffolds were tested in 32 Lewis rats in a femoral condylar defect model with untreated (negative), isograft (positive), and commercial HA as controls. Animals were survived for 12 weeks post‐implantation. A semi‐quantitative micro‐CT analysis was developed to quantify the percent new bone formation within the defects. Our model showed significantly higher (p < .05) new bone depositions in all apatite groups compared to the autograft group. Overall, the FA group had the most significant new bone deposition, while the differences between HA, FA, and FA + SVF were insignificant (p > .05). Histological observations supported the micro‐CT findings and highlighted the presence of healthy bone tissues without interposing capsules or intense immune responses for FA groups. Most importantly, the regenerating bone tissue within the FA + SVF scaffolds resembled the architecture of the surrounding trabecular bone, showing intertrabecular spaces, while the FA group presented a denser cortical bone‐like architecture. Also, a lower density of cells was observed near FA granules compared to HA surfaces, suggesting a reduced immune response. This first in vivo rat study supported the tested hypothesis, illustrating the utility of FA as a bone scaffold material.

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Fluorapatite ceramics for bone tissue regeneration: Synthesis, characterization and assessment of biomedical potential

Cited by 43 publications

References 37 publications

The Impact of Contaminating Poly (Methyl Methacrylate) (PMMA) Bone Cements on Their Compressive Strength

The Impact of Contaminating Poly (Methyl Methacrylate) (PMMA) Bone Cements on Their Compressive Strength

Highly Porous Fluorapatite/β-1,3-Glucan Composite for Bone Tissue Regeneration: Characterization and In-Vitro Assessment of Biomedical Potential

Sintered fluorapatite scaffolds as an autograft‐like engineered bone graft

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