Fluorescence Cystoscopy

Geavlete, B.; Geavlete, P.; Georgescu, D.; Multescu, R.; Jecu, M.

doi:10.1016/b978-0-12-802439-3.00002-5

Cited by 2 publications

(2 citation statements)

References 73 publications

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“…Fluorescence is a signal transducer measuring the emitted photons as the results from molecules absorbing light. Usually, the emitted photon has a longer wavelength than the excitation light [ 18 ]. A fluorescence enhancement strategy based on silver nanoparticle (AgNP) aggregates for detecting HBV DNA sequences was developed through functionalization of AgNPs with recognition probes (Cy3-probe) and hybrid probes (oligomers).…”

Section: Common Methods For Detection Of Hepatitis B Virusmentioning

confidence: 99%

Recent Advances of Hepatitis B Detection towards Paper-Based Analytical Devices

Tyas

Raeni

Sakti

et al. 2021

The Scientific World Journal

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Hepatitis B virus (HBV) still remains a major global public health problem. One-half to one-third of the total HBV infected people died due to late detection of HBV. Serological antigen and viral HBV detections can help in the diagnosis, referral, and treatment of HBV. Available methods for HBV detection mostly used bulky instruments. Miniaturization of devices for HBV detection has been started by narrowing down the size of the devices. Several methods have also been proposed to increase the selectivity and sensitivity of the miniaturized methods, such as sandwich recognition of the biomarkers and the use of nano- to micro-sized materials. This review presents recent HBV detections in the last two decades from laboratory-based instruments towards microfluidic paper-based analytical devices (µPADs) for point-of-care testing (POCT) purposes. Early and routine analysis to detect HBV as early as possible could be achieved by POCT, especially for areas with limited access to a central laboratory and/or medical facilities.

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Section: Common Methods For Detection Of Hepatitis B Virusmentioning

confidence: 99%

Recent Advances of Hepatitis B Detection towards Paper-Based Analytical Devices

Tyas

Raeni

Sakti

et al. 2021

The Scientific World Journal

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“…The PpIX-fluorescence is emitted preferentially from cancer cells following administration of 5-ALA (5-aminolevulinic acid) or its esters (e.g. HAL (hexyl-5-ALA)) (23). It was proven that PpIX is accumulated more in cancer cells than normal cells (24).…”

Section: Introductionmentioning

confidence: 99%

Singlet Oxygen Activatable Prodrugs of Paclitaxel, SN‐38, MMC and CA4: Nonmitochondria‐Targeted Prodrugs^†

Rahman

Thapa

Hurst

et al. 2022

Photochem & Photobiology

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We established a light-activatable prodrug strategy that produces the combination effect of photodynamic therapy (PDT) and site-specific chemotherapy. Prodrugs are activated by singlet oxygen (SO), generated from PS and visible or near IR light, in either intra-or inter-molecular manner. The goal of this study is to evaluate cytotoxic effects of nonmitochondriatargeted prodrugs of a number of anticancer drugs with different mechanisms of action. They were tested in both 2D and 3D in vitro conditions via inter-molecular activation of prodrugs by SO generated in mitochondria by protoporphyrin IX-PDT (PpIX-PDT). Prodrugs of anticancer drugs (paclitaxel, SN-38, combretastatin A4 and mitomycin C) were synthesized using facile and high-yielding reactions. Nonmitochondria-targeted prodrugs showed limited dark toxicity while all of them showed greatly enhanced phototoxicity compared to PpIX-PDT in the 2D culture model. Prodrugs generated up to about 95% cell killing at 2.5 lM when administered with hexylaminolevulinate (HAL) to produce Protoporphyrin IX in cancer cells in both 2D monolayer and 3D spheroids model. The data demonstrate that mitochondria-targeting of prodrugs is not fully essential for our inter-molecular activation prodrug strategy. The prodrug strategy also worked for anticancer drugs with diverse MOAs.

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Fluorescence Cystoscopy

Cited by 2 publications

References 73 publications

Recent Advances of Hepatitis B Detection towards Paper-Based Analytical Devices

Recent Advances of Hepatitis B Detection towards Paper-Based Analytical Devices

Singlet Oxygen Activatable Prodrugs of Paclitaxel, SN‐38, MMC and CA4: Nonmitochondria‐Targeted Prodrugs^†

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Fluorescence Cystoscopy

Cited by 2 publications

References 73 publications

Recent Advances of Hepatitis B Detection towards Paper-Based Analytical Devices

Recent Advances of Hepatitis B Detection towards Paper-Based Analytical Devices

Singlet Oxygen Activatable Prodrugs of Paclitaxel, SN‐38, MMC and CA4: Nonmitochondria‐Targeted Prodrugs†

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Product

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Singlet Oxygen Activatable Prodrugs of Paclitaxel, SN‐38, MMC and CA4: Nonmitochondria‐Targeted Prodrugs^†