Fluorescence Enhancement in Hot Spots of AFM-Designed Gold Nanoparticle Sandwiches

Bek, Alpan; Jansen, Reiner; Ringler, Moritz; Mayilo, Sergiy; Klar, Thomas A.; Feldmann, Jochen

doi:10.1021/nl072602n

Cited by 273 publications

(219 citation statements)

References 38 publications

(74 reference statements)

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“…The investigation of localized surface plasmons in metal nanoparticles has received intense interest owing to a number of related unique and useful optical properties, such as confinement of light at the metal surface and the control of both the far-field and near-field distribution of light (16,17). Depending on the details of the systems under investigation, fluorescence enhancement has been reported for fluorescent molecules, quantum dots, and rare-earth complexes near nanostructured metals through coupling with surface plasmons in metallic nanostructures (18)(19)(20)(21). This process, referred to as metal-enhanced fluorescence, offers promise for a range of applications, including sensor technology, solidstate lighting, microarrays, and single-molecule studies.…”

mentioning

confidence: 99%

Using silver nanowire antennas to enhance the conversion efficiency of photoresponsive DNA nanomotors

Yuan

Zhang²,

Chen³

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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Plasmonic near-field coupling can induce the enhancement of photoresponsive processes by metal nanoparticles. Advances in nanostructured metal synthesis and theoretical modeling have kept surface plasmons in the spotlight. Previous efforts have resulted in significant intensity enhancement of organic dyes and quantum dots and increased absorption efficiency of optical materials used in solar cells. Here, we report that silver nanostructures can enhance the conversion efficiency of an interesting type of photosensitive DNA nanomotor through coupling with incorporated azobenzene moieties. Spectral overlap between the azobenzene absorption band and plasmonic resonances of silver nanowires increases light absorption of photon-sensitive DNA motor molecules, leading to 85% close-open conversion efficiency. The experimental results are consistent with our theoretical calculations of the electric field distribution. This enhanced conversion of DNA nanomotors holds promise for the development of new types of molecular nanodevices for light manipulative processes and solar energy harvesting.energy conversion | localized surface plasmon | photo-driven nanomotor P lants harvest solar energy by photosynthesis, in which photosensitive biomolecules absorb energy from sunlight and convert it into chemical energy. Human beings utilize solar energy by fossil fuels, solar thermal systems, and, most frequently nowadays, by photovoltaic systems based on optoelectric materials (1). The design of new synthetic materials coupled with a mechanism to capture, convert, and store photon energy will provide new ways to utilize solar energy (2, 3). However, achieving high conversion efficiency remains a challenge in such energy conversion systems.Recently, DNA has received attention in material sciences, especially for the fabrication of nanomachines able to perform nanoscale movements in response to external stimuli (4-11). Experimental and theoretical studies on single DNA nanomachines have led to the development of new energy conversion strategies (12, 13). As one of the most popular phototransformable molecules, azobenzene and its derivatives can change the overall structure by cis-trans isomerisation mechanism. Using the photoisomerization of azobenzene to photo-regulate DNA hybridization, (14) we have designed a single-molecule light-driven DNA nanomotor (15) for the continuous production of energy in the form of mechanical work. This photon-fueled nanomotor is simple and easy to operate, promising a unique approach to harvest photonic energy. Herein, azobenzene derivatives act as element for energy absorption and DNA molecules movement act for mechanical energy export. As we know, solar thermal technology is a technology to harvest solar thermal energy that converts solar energy to movement of molecules and then produces heat caused by molecule thermal moving. In our design, solar energy is converted to close-open movement of DNA molecules. However, few DNA motor molecules can undergo the close-open conversion as a result of the low p...

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mentioning

confidence: 99%

Using silver nanowire antennas to enhance the conversion efficiency of photoresponsive DNA nanomotors

Yuan

Zhang²,

Chen³

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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“…[162][163][164] For this reason, planar and single-NP Surface Enhanced Fluorescence (SEF) cannot exceed 10-fold enhancement. [161][162][163][164][165][166] This limitation can be overcome by plasmonic hotspots between NPs packed with 10 nm gaps, 167 from which enhancement as high as 10 4 for a single molecule has been reported. 164 We used an electric field to control spacing of small NPs assembled within a conic nanocapillary and produce plasmonic hotspots with maximum SEF for HOP-NPs.…”

Section: Polymer Nanopores and Nanopipettesmentioning

confidence: 99%

Future microfluidic and nanofluidic modular platforms for nucleic acid liquid biopsy in precision medicine

et al. 2016

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Nucleic acid biomarkers have enormous potential in non-invasive diagnostics and disease management. In medical research and in the near future in the clinics, there is a great demand for accurate miRNA, mRNA, and ctDNA identification and profiling. They may lead to screening of early stage cancer that is not detectable by tissue biopsy or imaging. Moreover, because their cost is low and they are non-invasive, they can become a regular screening test during annual checkups or allow a dynamic treatment program that adjusts its drug and dosage frequently. We briefly review a few existing viral and endogenous RNA assays that have been approved by the Federal Drug Administration. These tests are based on the main nucleic acid detection technologies, namely, quantitative reverse transcription polymerase chain reaction (PCR), microarrays, and next-generation sequencing. Several of the challenges that these three technologies still face regarding the quantitative measurement of a panel of nucleic acids are outlined. Finally, we review a cluster of microfluidic technologies from our group with potential for point-of-care nucleic acid quantification without nucleic acid amplification, designed to overcome specific limitations of current technologies. We suggest that integration of these technologies in a modular design can offer a low-cost, robust, and yet sensitive/selective platform for a variety of precision medicine applications.

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“…Strongly coupled plasmonic nanostructures are particularly well suited to build biosensor-and spectroscopy devices as they have been shown to enhance Raman scattering and uorescence intensity and also shape the emission spectrum of single molecules that are positioned in the nanoantenna gap. [144][145][146] Nanoparticles optically trapped in a liquid at room temperature are subject to signicant Brownian motion. This motion is damped to a certain level by the strong gradient forces induced by the trapping laser.…”

Section: Manipulation Of Biomimetic and Biological Systemsmentioning

confidence: 99%

Optical trapping and manipulation of plasmonic nanoparticles: fundamentals, applications, and perspectives

et al. 2014

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This feature article discusses the optical trapping and manipulation of plasmonic nanoparticles, an area of current interest with potential applications in nanofabrication, sensing, analytics, biology and medicine. We give an overview over the basic theoretical concepts relating to optical forces, plasmon resonances and plasmonic heating. We discuss fundamental studies of plasmonic particles in optical traps and the temperature profiles around them. We place a particular emphasis on our own work employing optically trapped plasmonic nanoparticles towards nanofabrication, manipulation of biomimetic objects and sensing.

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Fluorescence Enhancement in Hot Spots of AFM-Designed Gold Nanoparticle Sandwiches

Cited by 273 publications

References 38 publications

Using silver nanowire antennas to enhance the conversion efficiency of photoresponsive DNA nanomotors

Using silver nanowire antennas to enhance the conversion efficiency of photoresponsive DNA nanomotors

Future microfluidic and nanofluidic modular platforms for nucleic acid liquid biopsy in precision medicine

Optical trapping and manipulation of plasmonic nanoparticles: fundamentals, applications, and perspectives

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