Journal of Pharmaceutical Sciences

1980

DOI: 10.1002/jps.2600690302

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Fluorescence Properties of Pseudomorphine and Congeners: Structure–Activity Relationships

William D. Darwin

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²

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Reagents and Solutions1

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1982

1982

2025

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Cited by 10 publications

(1 citation statement)

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“…The analytical data obtained for pseudomorphine was similar to that found in the literature [10,11,13,15]. …”

Section: Reagents and Solutionssupporting

confidence: 85%

Voltammetric Oxidation of Drugs of Abuse I. Morphine and Metabolites

Delerue–Matos²,

³

et al. 2004

Electroanalysis

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A detailed study of the electrochemical oxidative behavior of morphine in aqueous solution is reported. Through the synthesis of several metabolites and derivatives, pseudomorphine, morphine N-oxide, normorphine, dihydromorphine and 2-(N,N-dimethylaminomethyl)morphine, and their voltammetric study it was possible to identify the oxidation peaks for morphine. The anodic waves are related with the oxidation of phenolic and tertiary amine groups. It is also possible to verify that a poorly defined peak observable during morphine oxidation is not a consequence of further oxidation of pseudomorphine but due to formation of a dimer during phenolic group oxidation. The results obtained and especially those regarding the formation of a new polymer based on a CÀO coupling could be useful for clarifying the discoloration phenomenon occurring during storage of morphine solutions as well as leading to a better understanding of its oxidative metabolic pathways.

“…The analytical data obtained for pseudomorphine was similar to that found in the literature [10,11,13,15]. …”

Section: Reagents and Solutionssupporting

confidence: 85%

Voltammetric Oxidation of Drugs of Abuse I. Morphine and Metabolites

Delerue–Matos²,

³

et al. 2004

Electroanalysis

View full text Add to dashboard Cite

A detailed study of the electrochemical oxidative behavior of morphine in aqueous solution is reported. Through the synthesis of several metabolites and derivatives, pseudomorphine, morphine N-oxide, normorphine, dihydromorphine and 2-(N,N-dimethylaminomethyl)morphine, and their voltammetric study it was possible to identify the oxidation peaks for morphine. The anodic waves are related with the oxidation of phenolic and tertiary amine groups. It is also possible to verify that a poorly defined peak observable during morphine oxidation is not a consequence of further oxidation of pseudomorphine but due to formation of a dimer during phenolic group oxidation. The results obtained and especially those regarding the formation of a new polymer based on a CÀO coupling could be useful for clarifying the discoloration phenomenon occurring during storage of morphine solutions as well as leading to a better understanding of its oxidative metabolic pathways.

Development of highly sensitive and specific HPLC assay for plasma morphine using direct injection technique and post-column derivatization

¹

1998

Biomed. Chromatogr.

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No abstract

A solvent free normal-stacking micellar electrokinetic chromatography integrated with on-line chemical modification for measuring morphine and morphine-6-glucuronide in human serum

Zarad,

Shawky,

Elsamanoudie

et al. 2025

Microchemical Journal

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No abstract

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