Fluorescence Study of the Curcumin−Casein Micelle Complexation and Its Application as a Drug Nanocarrier to Cancer Cells

Sahu, Abhishek; Kasoju, Naresh; Bora, Utpal

doi:10.1021/bm800683f

Cited by 503 publications

(290 citation statements)

References 48 publications

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“…In the literature, cytotoxicity studies of HeLa cells showed that the IC 50 of free curcumin and complexed curcumin on bovine casein micelles was 14.85 and 12.69 μM, respecttively. The loaded curcumin has showed a cytotoxic effect that was comparable to that of free curcumin [17]. In this study, as control, Hela cells were kept in the culture medium without any treatment.…”

Section: Discussionmentioning

confidence: 95%

Self-Assembled Dextrin Nanogel as Curcumin Delivery System

Gonçalves¹

2012

JBNB

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Curcumin is a natural polyphenol with anti-oxidative, anti-inflammatory and anti-cancer properties. Its therapeutic potential is substantially hindered by the rather low water solubility and bioavailability, hence the need for suitable carriers. In this study, we show that self-assembled nanogels obtained from hydrophobically modified dextrin are effective curcumin nanocarriers. The stability and loading efficiency of curcumin-loaded nanogel depends on the nanogel/curcumin ratio. Higher stability of the formulation is achieved in water than in PBS buffer, as evaluated by dynamic light scattering and fluorescence measurements. The in vitro release profile, using sink conditions, indicates that dextrin nanogel may perform as a suitable carrier for the controlled release of curcumin. Biological activity of curcumin-loaded nanogel in HeLa cell cultures was assessed using the MTS assay.

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Section: Discussionmentioning

confidence: 95%

Self-Assembled Dextrin Nanogel as Curcumin Delivery System

Gonçalves¹

2012

JBNB

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“…The main advantages of such materials are the high biocompatibility and improved CUR efficiency on cervical (Sahu et al, 2008b;Curcio et al, 2015a) and lung (Curcio et al, 2015b) cancer cells in vitro and ovarian cancer with negligible immunogenicity in mice (Podaralla et al, 2012). Amphiphilic behavior was conferred to CT by conjugation with STA, allowing the obtainment of CUR carrier for the treatment of colon cancer both in vitro (primary cancer cells) and in vivo (orthotopic mice) with improved efficiency (Wang et al, 2012b).…”

Section: Polymeric Vesicular Systemsmentioning

confidence: 99%

Polyphenols delivery by polymeric materials: challenges in cancer treatment

et al. 2017

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Nanotechnology can offer different solutions for enhancing the therapeutic efficiency of polyphenols, a class of natural products widely explored for a potential applicability for the treatment of different diseases including cancer. While possessing interesting anticancer properties, polyphenols suffer from low stability and unfavorable pharmacokinetics, and thus suitable carriers are required when planning a therapeutic protocol. In the present review, an overview of the different strategies based on polymeric materials is presented, with the aim to highlight the strengths and the weaknesses of each approach and offer a platform of ideas for researchers working in the field.

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“…This depicts similar surroundings for Cur in both Cur NLCs and Cur-TCA 50 NLCs, which could be described by Cur encapsulation in the apolar core. 37 However, dashed arrows in Figure 2D specify the spectral shoulder of the native Cur at 350 nm, thus implying Cur presence in the polar environment, as supported by Leung and Kee. 1 h-NMr spectrum of s100 and s100-Tca (B); cur-Tca Nlcs for oral delivery of cur using bile-acid transporter (C).…”

Section: Preparation and Characterization Of Cur-tca Nlcsmentioning

confidence: 60%

Improving intestinal absorption and oral bioavailability of curcumin via taurocholic acid-modified nanostructured lipid carriers

Tian¹,

Asghar²,

Wu³

et al. 2017

IJN

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The expression of multiple receptors on intestinal epithelial cells enables an actively targeted carrier to significantly enhance the oral delivery of payloads. Conjugating the receptors’ ligands on the surfaces of a particulate-delivery system allows site-specific targeting. Here, we used taurocholic acid (TCA) as a ligand for uptake of nanostructured lipid carriers (NLCs) mediated by a bile-acid transporter to improve oral bioavailability of curcumin (Cur). First, synthesis of TCA–polyethylene glycol 100–monostearate (S100-TCA) was carried out. Then, the physical and chemical properties of S100-TCA-modified Cur-loaded NLCs (Cur-TCA NLCs) with varying levels of S100-TCA modifications were investigated. Small particle size (<150 nm), high drug encapsulation (>90%), drug loading (about 3%), negative ζ-potential (−7 to −3 mV), and sustained release were obtained. In situ intestinal perfusion studies demonstrated improved absorption rate and permeability coefficient of Cur-TCA NLCs. Depending on the degree of modification, Cur-TCA NLCs displayed about a five- to 15-fold higher area under the curve in rats after oral administration than unmodified Cur NLCs, which established that the addition of S100-TCA to the NLCs boosted absorption of Cur. Further investigations of TCA NLCs might reveal a bright future for effective oral delivery of poorly bioavailable drugs.

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Fluorescence Study of the Curcumin−Casein Micelle Complexation and Its Application as a Drug Nanocarrier to Cancer Cells

Cited by 503 publications

References 48 publications

Self-Assembled Dextrin Nanogel as Curcumin Delivery System

Self-Assembled Dextrin Nanogel as Curcumin Delivery System

Polyphenols delivery by polymeric materials: challenges in cancer treatment

Improving intestinal absorption and oral bioavailability of curcumin via taurocholic acid-modified nanostructured lipid carriers

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