Fluorescence “turn-off/turn-on” biosensing of metal ions by gold nanoclusters, folic acid and reduced graphene oxide

Wong, Xin Yi; Quesada-González, Daniel; Manickam, Sivakumar; Muthoosamy, Kasturi

doi:10.1016/j.aca.2021.338745

Cited by 16 publications

(3 citation statements)

References 56 publications

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“…[53][54][55][56] An example is the concentration of potassium ions which is twice in cancer cells compared to that of normal cells. 57,58 Metal complexes can be designed to cause disruption of metal ion homeostasis, which in turn could lead to cell cycle perturbations and apoptosis. [59][60][61][62][63]…”

Section: Copper Homeostasis and Cancer Therapymentioning

confidence: 99%

Addressing the gaps in homeostatic mechanisms of copper and copper dithiocarbamate complexes in cancer therapy: a shift from classical platinum-drug mechanisms

et al. 2023

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Section: Copper Homeostasis and Cancer Therapymentioning

confidence: 99%

Addressing the gaps in homeostatic mechanisms of copper and copper dithiocarbamate complexes in cancer therapy: a shift from classical platinum-drug mechanisms

et al. 2023

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“…The intra-day (n = 5) and inter-day (n = 5) precisions (RSDs, %) at BPA 5 μg mL −1 , 4-⊍-CP 5 μg mL −1 , 4-t-OP 10 μg mL −1 and 4-NP 25 μg mL −1 were 2.8-7.1%, and 1.6-8.3%, respectively. According to the reported methods of LOD and LOQ calculation, 19 the LODs and LOQs of investigated EDCs were 6-1.2 ng mL −1 and 0.002-0.004 μg mL −1 , respectively. The magnetic covalent organic frameworks gave large EFs of 92.694, 129.689, 78.659, and 111.046 for BPA, 4-⊍-CP, 4-t-OP, and 4-NP, respectively.…”

Section: Methods Validationmentioning

confidence: 99%

Magnetic covalent organic frameworks for extraction and determination of endocrine‐disrupting chemicals in beverage and water samples

Zhao

Yang

et al. 2023

J Sci Food Agric

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BackgroundPhenolic endocrine‐disrupting chemicals (EDCs) are widespread and easily ingested through the food chain and pose great threat to human health. Duo to the low level of phenolic EDCs and complex food and environment matrix, magnetic solid phase extraction (MSPE) is an effective sample pre‐treatment technology to determine trace phenolic EDCs.ResultsMagnetic covalent organic frameworks (Fe3O4@COFs) nanospheres were prepared and well characterized. The efficient and selective extraction of phenolic EDCs relies on large specific surface and inherent porosity of COFs and the hydrogen bonding, π‐π and hydrophobic interactions between COF shell and phenolic EDCs. Under the optimal conditions, the proposed MSPE‐HPLC‐UV based on Fe3O4@COFs method for phenolic EDCs show good linearities (0.002‐6.000 μg mL‐1) with R2 (≥0.995) and low limit of detections (6.000‐1.200 ng mL‐1).ConclusionFe3O4@COFs with good MSPE performance for phenolic EDCs are synthesized by the solvothermal method. The developed Fe3O4@COFs based MSPE‐HPLC‐UV method is successfully applied to determine phenolic EDCs in beverage and water samples with satisfactory recoveries (90.200‐123.000%) and relative standard deviations (2.100‐12.100%).This article is protected by copyright. All rights reserved.

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“…The biosensor was used for the detection of two metal ions (e.g., Na + and K + ) using ribonuclease A (RNase A) that can be used as therapeutic protein. The RNaseA/AuNCs were loaded onto FA-rGO, and hence the composite can be used as a potential DDS and fluorescence quencher [ 253 ]. Another material that has been thoroughly explored is the combination of mesoporous silica NPs (MSNPs) with MNCs/inorganic NPs.…”

Section: Nano-based Building Blocksmentioning

confidence: 99%

Nanocluster-Based Drug Delivery and Theranostic Systems: Towards Cancer Therapy

2022

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Over the last decades, the global life expectancy of the population has increased, and so, consequently, has the risk of cancer development. Despite the improvement in cancer therapies (e.g., drug delivery systems (DDS) and theranostics), in many cases recurrence continues to be a challenging issue. In this matter, the development of nanotechnology has led to an array of possibilities for cancer treatment. One of the most promising therapies focuses on the assembly of hierarchical structures in the form of nanoclusters, as this approach involves preparing individual building blocks while avoiding handling toxic chemicals in the presence of biomolecules. This review aims at presenting an overview of the major advances made in developing nanoclusters based on polymeric nanoparticles (PNPs) and/or inorganic NPs. The preparation methods and the features of the NPs used in the construction of the nanoclusters were described. Afterwards, the design, fabrication and properties of the two main classes of nanoclusters, namely noble-metal nanoclusters and hybrid (i.e., hetero) nanoclusters and their mode of action in cancer therapy, were summarized.

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Fluorescence “turn-off/turn-on” biosensing of metal ions by gold nanoclusters, folic acid and reduced graphene oxide

Cited by 16 publications

References 56 publications

Addressing the gaps in homeostatic mechanisms of copper and copper dithiocarbamate complexes in cancer therapy: a shift from classical platinum-drug mechanisms

Addressing the gaps in homeostatic mechanisms of copper and copper dithiocarbamate complexes in cancer therapy: a shift from classical platinum-drug mechanisms

Magnetic covalent organic frameworks for extraction and determination of endocrine‐disrupting chemicals in beverage and water samples

Nanocluster-Based Drug Delivery and Theranostic Systems: Towards Cancer Therapy

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