Fluorescent carbon dots derived from urine and their application for bio-imaging

Zhang, Xue-Di; Li, Jun; Niu, Jianing; Bao, Xuan-Ping; Zhao, Hailin; Tan, Mingqian

doi:10.1016/j.ymeth.2019.04.005

Cited by 30 publications

(11 citation statements)

References 30 publications

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“…The result demonstrated that the fluorescent CDs origined from daily food may provide a facile and green strategy for preparing N-doped CDs with strong fluorescence in bio-imaging. The second paper by Zhang et al used the human metabolites (urine) as the precursor for CDs preparation in bio-imaging via a simple, economical, one-step synthetic route [17]. The prepared CDs showed great potential in bio-imaging in live cells, Caenorhabditis elegans, onion epidermal cells and bean sprouts.…”

Section: Guest Editor's Introduction Methods For Biosensing and Imagingmentioning

confidence: 99%

Methods for biosensing and imaging

Zhang

Tan

2019

Methods

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Section: Guest Editor's Introduction Methods For Biosensing and Imagingmentioning

confidence: 99%

Methods for biosensing and imaging

Zhang

Tan

2019

Methods

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“…Different characterization techniques revealed that both types of Figure 6: Graphical illustration for the synthesis of CDs from human urine and their application for bioimaging. Figure 6 was reprinted from [116], Methods, vol. 168, by X. Zhang; J. Li; J. Niu; X. Bao; H. Zhao; M. Tan, "Fluorescent carbon dots derived from urine and their application for bioimaging", pages 84-93, Copyright Elsevier (2019), with permission from Elsevier.…”

Section: Animal Extractmentioning

confidence: 99%

“…Different characterization techniques revealed that both types of CDs consisted of carbon and oxygen and indicated the existence of different functional groups such as amino, carboxylate, carbonyl, and hydroxy groups. The cytotoxicity study showed good biocompatibility and applicability in both in vitro and in vivo imaging [ 116 ].…”

Section: Reviewmentioning

confidence: 99%

“…Luminous CDs displaying less cytotoxicity and strong biocompatibility were prepared from apple juice and were successfully employed in the bioimaging of various bacterial and fungal cells [ 178 ]. In another study of Zhang et al [ 116 ], urine-based CDs (UCDs) and hydrothermally treated urine CDs (HUCDs) were synthesized by utilizing a simple sephadex filtration procedure and a hydrothermal reaction approach. The prepared UCDs and HUCDs were used for in vivo and in vitro bioimaging of cells and displayed good biocompatibility and no toxicity to normal rat kidney cells.…”

Section: Reviewmentioning

confidence: 99%

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Recent advances in green carbon dots (2015–2022): synthesis, metal ion sensing, and biological applications

Kanwal¹,

Bibi²,

Hyder³

et al. 2022

Beilstein J. Nanotechnol.

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Carbon dots (CDs) show extensive potential in various fields such as sensing, bioimaging, catalysis, medicine, optoelectronics, and drug delivery due to their unique properties, that is, low cytotoxicity, cytocompatibility, water-solubility, multicolor wavelength tuned emission, photo-stability, easy modification, strong chemical inertness, etc. This review article especially focuses on the recent advancement (2015–2022) in the green synthesis of CDs, their application in metal ions sensing and microbial bioimaging, detection, and viability studies as well as their applications in pathogenic control and plant growth promotion.

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“…On the contrary, bottom‐up synthesis primarily involves pyrolysis or carbonization of organic matters (generally making use of easily available organic molecules, natural animals, and plants resources), growing into the form of CDs through microwave irradiation, [ 70–78 ] hydrothermal/solvothermal treatment, [ 79–83 ] thermal decomposition, [ 84–86 ] heating, or refluxing process. [ 87,88 ] Meanwhile, it includes for plasma technology, [ 89–91 ] carbonization, [ 92,93 ] ultrasonic preparation, [ 94 ] photoirradiation, [ 95 ] and electrochemical synthesis.…”

Section: The Preparation Of Multicolor Cdsmentioning

confidence: 99%

Preparation and Biomedical Applications of Multicolor Carbon Dots: Recent Advances and Future Challenges

Huo

Karmaker

Liu

et al. 2020

Part & Part Syst Charact

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as 0D and discrete, quasispherical nanoparticles with the characteristic size of less than 10 nm in shape. In the past few decades, many researchers have been intrigued by overwhelming application of CDs in fields other than solar photovoltaics, [23][24][25] semiconductor photocatalysis, [26] or light-emitting materials, [27][28][29] like in bioimaging, [30][31][32][33] drug delivery/ release, [34][35][36] theranostics, [37] and biosensing/bioassay. [38][39][40] Albeit with biological imaging agents in vitro and in vivo, heavy metals as the essential elements for the core materials of available high-performance semiconductor quantum dots (QDs) exist substantial toxicity, carcinogenic effects, and environmental hazard, even at low levels. [41][42][43][44][45] Historically, boasting the natural virtues of fascinating optical properties (e.g., up/down-conversion and excitation-dependent fluorescence emission, high fluorescence quantum yields (QY), and long fluorescence lifetime), eco-friendliness, high waterdispersible peculiarity, easy surface-functionality, low cost, highly abundant, and inexpensive raw materials, noninvasiveness, low cytotoxicity, and good biocompatibility afford CDs suitable as the elegant alternatives for toxic QDs containing heavy metals. [46][47][48][49] On the other hand, the CDs have excellent photostability against photobleaching and photoblinking as compared with the conventional organic dyes (typically fluorescein and rhodamine B). [50] In particular, multicolor CDs exhibit tunable photoluminescence by exciting the identical CDs, allowing for multimodal biophotosensitizer in biological field without interference from background autofluorescence. In this review, we aim to systematically offer a summary of preparing multicolor CDs and its various biomedical applications, mainly including for bioimaging, drug delivery/release, theranostics, and biosensing/bioassay, highlighting the complete horizons of multiplexed quantitative detection, high-resolution fluorescence imaging, and long-term, real-time monitoring of multicolor CDs.Multicolor carbon dots (CDs) as an emerging subclass of carbonaceous nanomaterials have inspired intensive attention due to the fascinating fluorogenic properties of quantum dots, exhibiting great potential applications in the biomedical field. In some cases, reported CDs with blue or green fluorescence are not desirable for further biological applications owing to the conflicting background autofluorescence, low penetration, and relatively large damage to biological tissue. However, multicolor CDs that can work in the longer wavelength region are being developed to address this issue by overcoming the autofluorescence from the cellular components (usually in the blue and green range). In this review, the development of multicolor CDs is described comprehensively, including for red-emissive or NIR-emissive CDs. Additionally, the preparation methods of multicolor CDs are summarized. Moreover, the factors affecting the luminescence of multicolor CDs are discussed in de...

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Fluorescent carbon dots derived from urine and their application for bio-imaging

Cited by 30 publications

References 30 publications

Methods for biosensing and imaging

Methods for biosensing and imaging

Recent advances in green carbon dots (2015–2022): synthesis, metal ion sensing, and biological applications

Preparation and Biomedical Applications of Multicolor Carbon Dots: Recent Advances and Future Challenges

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