Fluorescent chitosan nanoparticles as a carrier system for trackable drug delivery

Padilha, Andreia Carvalho; Vivas, Marcelo G.; Melo, Maria do Socorro Fernandes; Campos, Maria Gabriela Nogueira

doi:10.1080/25740881.2020.1867169

Cited by 4 publications

(5 citation statements)

References 41 publications

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“…As a result, the effect was that the lifetime of the fluorescence increased with concentration, and this may be attributed to polarity. The solvent decreases the area of the CS's molecular diffusion and speeds up energy transfers, which boosts the fluoridation's quantitative output, this value agree with the works of the researcher [19,20].…”

Section: Consequences and Discussion 31 Structural Propertiessupporting

confidence: 85%

Studying the effect of concentration on spectral and optical properties of chitosan polymer

Abdul-razzaq¹

2023

PEN

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Due to its noteworthy physico-chemical behaviors, the chitosan (CS) biopolymer presents a compelling alternative to conventional biomaterials. By measuring the emission spectra at a spectrofluorophotometer in different concentrates (1x10 -4 , 1x10 -5 , and 1x10 -6 ) M, the spectral characteristics of the CS polymer were obtained. The crystallinity of the CS polymer was determined by X-ray diffraction (XRD) analysis, which shows only one dominant peak indexed to the orthorhombic structure. With a drop in solution concentration, there was a shift toward the shorter wavelength and a decline in quantum yield. Using a UV-Vis spectrophotometer, the optical properties of the CS polymer, including its refractive index, absorption coefficient, energy band gap, extinction coefficient, and dielectric constant, have been studied. It was observed through the results that the optical parameters are linearly dependent with concentration. In contrast to the optical energy gap, which decreases with increasing concentration .

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Section: Consequences and Discussion 31 Structural Propertiessupporting

confidence: 85%

Studying the effect of concentration on spectral and optical properties of chitosan polymer

Abdul-razzaq¹

2023

PEN

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“…When transported to the target cell, nanoparticles can protect payloads such as vaccine antigens, proteins, nucleic acids, and medicines from destruction. ( Grabowska et al, 2021 ; Padilha et al, 2021 ; Yousefi et al, 2021 ). Compared to viral vectors, nanoparticles are non-viral delivery vehicles, easier to process and modify, biocompatible, biodegradable, and more favourable safety profiles ( ShenJ et al, 2013 ; S. Arany et al, 2013 ; Y.C.…”

Section: Introductionmentioning

confidence: 99%

Identification of nanoparticle-mediated siRNA-ASPN as a key gene target in the treatment of keloids

Dong

Zhang²,

Zhang³

et al. 2022

Front. Bioeng. Biotechnol.

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Background: Keloid, also known as connective tissue hyperplasia, is a benign proliferative disorder with a global distribution. The available therapeutic interventions are steroid injections, surgical removal of keloids, radiotherapy, compression therapy, the application of cryosurgery, and many other methods.Objectives: Existing treatments or approaches for keloids may lead to similar or even larger lesions at the site of keloid excision, leading to a high recurrence rate. Therefore, this study aims at identifying a new gene-based therapy for the treatment of keloids.Methods: An ASPN-siRNA/nanoparticle combination (si-ASPN) and a negative siRNA/nanoparticle complex (NC) was developed on the basis of bioinformatics studies and used in vitro and in vivo experiments.Results: The results showed a strong correlation between the development of keloids and high expression of ASPN protein. With the expression of ASPN protein greatly reduced in keloid fibroblasts and nude mice allografts after treatment with si-ASPN, the collagen and fibroblasts were also uniform, thinner, parallel and regular.Conclusion: All the above experimental results suggest that keloid and ASPN are closely related and both fibroblast growth and metabolism of keloid are inhibited after silencing ASPN. Therefore, ASPN-siRNA delivered via nanoparticles can serve as a novel intervention therapy for the treatment of keloids.

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“…Based on a review of the current literature, fluorescent chitosan, due to its unique properties, is the subject of numerous studies [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ]. As shown recently, it can be successfully modified with various organic fluorophores, e.g., rhodamine-based dyes [ 33 , 34 , 35 ], coumarin [ 36 ], BODIPY-type compounds, which are dyes consisting of boron difluoride and a dipyrromethene group (e.g., BODIPY containing additional nitro or amino substituents) [ 37 ], a derivative of fluorescein [ 38 , 39 ] or substituted naphthalimides [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

“…Apart from the chemical substitution of organic dyes, there are descriptions of obtaining fluorescent chitosan without the use of photosensitive modifiers. An example is a work by Padilha et al [ 41 ], in which fluorescent chitosan nanoparticles were obtained in the process of hydrothermal treatment. Simultaneous use of a hydrochloric acid solution led to the depolymerization of the macromolecules.…”

Section: Introductionmentioning

confidence: 99%

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Fluorescent Chitosan Modified with Heterocyclic Aromatic Dyes

et al. 2021

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Chitosan is a valuable, functional, and biodegradable polysaccharide that can be modified to expand its applications. This work aimed to obtain chitosan derivatives with fluorescent properties. Three heterocyclic aromatic dyes (based on benzimidazole, benzoxazole, and benzothiazole) were synthesized and used for the chemical modification of chitosan. Emission spectroscopy revealed the strong fluorescent properties of the obtained chitosan derivatives even at a low N-substitution degree of the dye. The effect of high-energy ultraviolet radiation (UV–C) on modified chitosan samples was studied in solution with UV–Vis spectroscopy and in the solid state with FTIR spectroscopy. Moreover, cytotoxicity towards three different cell types was evaluated to estimate the possibilities of biomedical applications of such fluorescent chitosan-based materials. It was found that the three new derivatives of chitosan were characterized by good resistance to UV–C, which suggests the possibility of using these materials in medicine and various industrial sectors.

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Fluorescent chitosan nanoparticles as a carrier system for trackable drug delivery

Cited by 4 publications

References 41 publications

Studying the effect of concentration on spectral and optical properties of chitosan polymer

Studying the effect of concentration on spectral and optical properties of chitosan polymer

Identification of nanoparticle-mediated siRNA-ASPN as a key gene target in the treatment of keloids

Fluorescent Chitosan Modified with Heterocyclic Aromatic Dyes

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