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Zizyphus joazeiro Mart. árvore bastante disseminada no nordeste brasileiro, utilizada como agente de higienização bucal, em substituição aos produtos comerciais. Usa-se o fruto nas perturbações do estômago e as cascas na cicatrização de ferimentos, febres e infecções dos pulmões. O presente estudo objetiva avaliar a atividade antimicrobiana, in vitro dos diferentes extratos de Zizyphus joazeiro Mart frente á microrganismos, incluindo leveduras, bactérias Grampositiva, Gram-negativa e Mycobacterium bovis. Os extratos foram preparados utilizando as partes aéreas (casca do caule, folhas e frutos) de Zizyphus joazeiro Mart. Esses foram testados quanto a sua atividade antimicrobiana, contra leveduras e bactérias utilizando o método de difusão em agar. Todos os extratos apresentaram atividade antimicrobiana. Dos microrganismos utilizados somente Bacillus subtilis, Staphylococcus aureus e Candida albicans mostraram-se sensíveis. Nenhum dos extratos testados apresentou atividade sobre Mycobacterium bovis. Estes resultados podem explicar em parte a utilização Zizyphus joazeiro Mart. para o tratamento de doenças infecciosas na medicina tradicional. Palavras-chave: Zizyphus joazeiro. Extratos vegetais. Antimicrobiana. Antimicobacteriana. M.bovis

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The aim of this work was to extract, characterize and incorporate the extract of Passiflora edulis in to chitosan membranes for potential application as wound dressing. The extract was obtained from leaves using hydroalcoholic maceration. The extract (EPE) was analyzed by LC-Mass and Infrared Spectroscopy for identification of characteristic compounds, and further incorporated to chitosan membrane (QEPE). The membranes were obtained by solvent evaporation technique and characterized by morphology (SEM), swelling behavior, moisture content, water-solubility, water vapor permeability, and thermal stability. The interactions between chitosan and the extract were also analyzed by infrared spectroscopy. The presence of flavonoids (hydrophilic compounds) in EPE affected the moisture content, water-solubility and water-vapor permeability of QEPE by increasing these properties in respect to the values found for the chitosan only membrane (QF). No significant difference was observed in the swelling ratio of both membranes. Moreover, a reduction in the enthalpy of fusion and hence in the degree of crystallinity was observed for QEPE, probably due to the presence of phenolic compounds in the extract that difficult orientation and organization of the polymeric chains due to the steric effect. In conclusion, QEPE was flexible, transparent, and homogeneous; demonstrated fluid absorption capacity, water vapor permeability and thermal stability under physiological conditions. Therefore, it has great potential for application in the treatment of skin wounds.