1995
DOI: 10.1016/0165-4608(95)00036-4
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Fluorescent in situ hybridization studies of lymphocytes and neutrophils in chronic granulocytic leukemia

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Cited by 29 publications
(18 citation statements)
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“…[16][17][18] Therefore, the application of alternative methods is essential for further clarification of clonal constitution in myeloid disorders. In this regard, karyotype, 19,20 FISH, 15,21 or Ras mutational analysis 14 have been applied to either fractionated cell populations or in vitro progenitor colonies. In most, but not all, 14,15 instances, the results have been consistent with those derived from X-linked clonality assays.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…[16][17][18] Therefore, the application of alternative methods is essential for further clarification of clonal constitution in myeloid disorders. In this regard, karyotype, 19,20 FISH, 15,21 or Ras mutational analysis 14 have been applied to either fractionated cell populations or in vitro progenitor colonies. In most, but not all, 14,15 instances, the results have been consistent with those derived from X-linked clonality assays.…”
Section: Resultsmentioning
confidence: 99%
“…[10][11][12][13] Other studies, using different clonal assays, have suggested monoclonality of T lymphocytes in both MMM (based on Ras mutational analysis) 14 and CML (based on fluorescent in situ hybridization [FISH] analysis). 15 In the current study, we evaluated 4 patients with MMM who had clonal chromosome abnormalities that could be identified by FISH in interphase nuclei in highly purified cell fractions.…”
Section: Introductionmentioning
confidence: 99%
“…At variance with these findings is the observation of comparable levels of BCR/ABL + cells in PB and BM granulocytes in other studies. 9,25 In conclusion, we have shown that dual-color FISH enables an accurate detection and monitoring of the size of the Phpositive clone in CML under IFN. While our findings are reassuring with respect to the reliability of conventional cytogenetics in the follow-up of CML, interphase cytogenetics offers the advantage of being more sensitive and accurate, especially in cytogenetically responder patients, having a minority of Ph-positive cells.…”
Section: Figurementioning
confidence: 99%
“…2,[42][43][44][45] There is some controversy over whether lymphocytes are of leukemia origin in CML. Garicochea et al 46 reported that T lymphocytes had no bcr/abl fusion gene, while Tefferi et al 42 demonstrated that t(9;22) was detectable in 34% of CD3-positive T lymphocytes, in 32% of CD19-positive B lymphocytes and in 82% of CD34-positive precursor cells. In the present study, one patient in blast crisis of CML had 100% FISH-positive cells in her peripheral blood, which consisted of blasts, immature and mature neutrophils, basophils, eosinophils, monocytes and lymphocytes.…”
Section: Discussionmentioning
confidence: 99%