Fluorescent molecularly imprinted polymer film binds glucose with a concomitant changes in fluorescence

Manju, S.; Hari, P.R.; Sreenivasan, K.

doi:10.1016/j.bios.2010.07.025

Cited by 44 publications

(16 citation statements)

References 26 publications

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“…It could be argued that the increased use of MIPs in sensor development has been in part driven by developments in MIP formats, not least by the establishment of reproducible strategies for thin film, fiber and (nano)particle preparation. Optical,…”

Section: Applicationsmentioning

confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

2014

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SummaryHerein we present a survey of the literature covering the development of molecular imprinting science and technology over the years 2004 to 2011. In total, 3779 references to the original papers, reviews, edited volumes and monographs from this period are included, along with recently identified uncited materials from prior to 2004 which were omitted in the first instalment of this series covering the years 1930 to 2003. 1 In the presentation of the assembled references, a section presenting reviews and monographs covering the area is followed by sections describing fundamental aspects of molecular imprinting including the development of novel polymer formats. Thereafter, literature describing efforts to apply these polymeric materials to a range of application areas is presented. Current trends and areas of rapid development are discussed.2

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Section: Applicationsmentioning

confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

2014

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“…Molecularly imprinted polymers (MIPs), [7] which are chemical receptors synthesized through polymerization in the presence of at emplate,h ave developed into important functional materials with antibody-like binding properties or enzyme-like catalytic activities,a nd they have found wide applications from sensing to separation to catalysis.Although MIPs specific to sugars,particularly glucose,have been widely reported, [8] to the best of our knowledge,M IPs that can recognize both an intact glycoprotein and its characteristic fragments have not been reported to date.Recently,byusing boronic acids as functional moieties,M IPs with excellent binding properties have been developed for the specific recognition of glycoproteins,a nd these MIPs have exhibited great potential for real-world applications such as medical diagnostics. [9] These studies inspired us to further mimic lectins by combining boronate affinity and molecular imprinting.…”

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confidence: 90%

Boronate‐Affinity Glycan‐Oriented Surface Imprinting: A New Strategy to Mimic Lectins for the Recognition of an Intact Glycoprotein and Its Characteristic Fragments

et al. 2015

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Lectins possess unique binding properties and are of particular value in molecular recognition. However, lectins suffer from several disadvantages, such as being hard to prepare and showing poor storage stability. Boronate-affinity glycan-oriented surface imprinting was developed as a new strategy for the preparation of lectin-like molecularly imprinted polymers (MIPs). The prepared MIPs could specifically recognize an intact glycoprotein and its characteristic fragments, even within a complex sample matrix. Glycan-imprinted MIPs could thus prove to be powerful tools for important applications such as proteomics, glycomics, and diagnostics.

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“…32,[34][35] Many efforts have been dedicated to the development of methods for tear glucose detection and monitoring, including glucose-sensitive photonic crystals, 36 holographic sensors, 37 and molecularly-imprinted fluorescent sensors. 38 Glucose sensitive-contact lenses were also proposed. [39][40] However, many of these methods are based on electrical readouts.…”

Section: Introductionmentioning

confidence: 99%

Laser-inscribed contact lens sensors for the detection of analytes in the tear fluid

Moreddu

Wolffsohn

Vigolo

et al. 2020

Sensors and Actuators B: Chemical

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Tears exhibit compositional variations as a response to ocular and systemic metabolic conditions, and they can therefore be used for the assessment of physiological health. Here, microfluidic contact lenses were developed as wearable platforms for in situ tear pH, glucose, protein, and nitrite ions sensing. The microfluidic system was inscribed in commercial contact lenses by CO2 laser ablation. The microchannel consisted on a central ring with four branches, and biosensors were embedded within microcavities located at the branches ends. The device was tested with artificial tears and colorimetric readouts were performed using a smartphone-MATLAB algorithm based on the nearest neighbor model. Sensors responded within a time range of 15 seconds, and yielded sensitivities of 12.23 nm/pH unit, 1.4 nm/mmolL -1 of glucose, 0.49 nm/gL -1 of proteins, and 0.03nm/μmolL -1 of nitrites. Contact lens sensing platforms may provide on-eye tears screening with applications in the monitoring of the ocular health both in clinics and at point-of-care settings.

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Fluorescent molecularly imprinted polymer film binds glucose with a concomitant changes in fluorescence

Cited by 44 publications

References 26 publications

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011

Boronate‐Affinity Glycan‐Oriented Surface Imprinting: A New Strategy to Mimic Lectins for the Recognition of an Intact Glycoprotein and Its Characteristic Fragments

Laser-inscribed contact lens sensors for the detection of analytes in the tear fluid

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