Fluorescent PLLA-nanodiamond composites for bone tissue engineering

Zhang, Qingwei; Mochalin, Vadym; Neitzel, Ioannis; Knoke, Isabel; Han, Jin‐Hee; Klug, Christopher A.; Zhou, Jack G.; Lelkes, Peter I.; Gogotsi, Yury

doi:10.1016/j.biomaterials.2010.08.090

Cited by 374 publications

(278 citation statements)

References 35 publications

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“…Zhang et al [70] prepared PLA/octadecylaminefunctionalized nano-diamond (ND-ODA) composites for use in tissue engineering. The composites were prepared using a solution method where PLA was dissolved in chloroform whereas ND-ODA was dispersed in chloroform and sonicated.…”

Section: Medical Applications 41 Tissue Engineeringmentioning

confidence: 99%

Properties and medical applications of polylactic acid: A review

Hamad¹,

Kaseem²,

Yang

et al. 2015

Express Polym. Lett.

597

306

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Abstract. Polylactic acid (PLA), one of the well-known biodegradable polyesters, has been studied extensively for tissue engineering and drug delivery systems, and it was also used widely in human medicine. A new method to synthesize PLA (ring-opening polymerization), which allowed the economical production of a high molecular weight PLA polymer, broadened its applications, and this processing would be a potential substitute for petroleum-based products. This review described the principles of the polymerization reactions of PLA and, then, outlined the various materials properties affecting the performance of PLA polymer, such as rheological, mechanical, thermal, and barrier properties as well as the processing technologies which were used to fabricate products based on PLA. In addition, the biodegradation processes of products which were shaped from PLA were discussed and reviewed. The potential applications of PLA in the medical fields, such as tissue engineering, wound management, drugs delivery, and orthopedic devices, were also highlighted.

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Section: Medical Applications 41 Tissue Engineeringmentioning

confidence: 99%

Properties and medical applications of polylactic acid: A review

Hamad¹,

Kaseem²,

Yang

et al. 2015

Express Polym. Lett.

597

306

View full text Add to dashboard Cite

show abstract

“…ND particles, which are capable of mediating improved efficacy and safety by forming complexes around the active agent while preserving its innate functionality (20)(21)(22)(23)(24)(25)(26)(27). ND safety and biocompatibility have been clearly demonstrated in numerous applications ranging from oncology to wound healing (28)(29)(30)(31)(32)(33)(34)(35). Similarly, hydrogels have been extensively used for tissue engineering and drug delivery applications due to their high biocompatibility (36).…”

Section: Significancementioning

confidence: 99%

Reducing posttreatment relapse in cleft lip palatal expansion using an injectable estrogen–nanodiamond hydrogel

Hong

Song

Lee

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Patients with cleft lip and/or palate (CLP), who undergo numerous medical interventions from infancy, can suffer from lifelong debilitation caused by underdeveloped maxillae. Conventional treatment approaches use maxillary expansion techniques to develop normal speech, achieve functional occlusion for nutrition intake, and improve esthetics. However, as patients with CLP congenitally lack bone in the cleft site with diminished capacity for bone formation in the expanded palate, more than 80% of the patient population experiences significant postexpansion relapse. While such relapse has been a long-standing battle in craniofacial care of patients, currently there are no available strategies to address this pervasive problem. Estrogen, 17β-estradiol (E2), is a powerful therapeutic agent that plays a critical role in bone homeostasis. However, E2's clinical application is less appreciated due to several limitations, including its pleiotropic effects and short half-life. Here, we developed a treatment strategy using an injectable system with photo-crosslinkable hydrogel (G) and nanodiamond (ND) technology to facilitate the targeted and sustained delivery of E2 to promote bone formation. In a preclinical expansion/relapse model, this functionalized E2/ ND/G complex substantially reduced postexpansion relapse by nearly threefold through enhancements in sutural remodeling compared with unmodified E2 administration. The E2/ND/G group demonstrated greater bone volume by twofold and higher osteoblast number by threefold, compared with the control group. The E2/ND/G platform maximized the beneficial effects of E2 through its extended release with superior efficacy and safety at the local level. This broadly applicable E2 delivery platform shows promise as an adjuvant therapy in craniofacial care of patients.nanomedicine | cleft palate | craniofacial medicine | nanodiamond | drug delivery

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“…This suggested that the incorporation of PLLA in higher quantities resulted in the increase in the crystallinity of the scaffolds. [29,30] The peak at 18.5° 2θ was present in all the scaffolds. The d-spacing, crystallite size (D), and lattice strain (Table 2) were calculated using the peak details at 18.5° 2θ.…”

Section: Mechanical Analysismentioning

confidence: 90%

Evaluation of poly(L-lactide) and chitosan composite scaffolds for cartilage tissue regeneration

Mallick

Pal

Rastogi

et al. 2016

Designed Monomers and Polymers

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The present study delineates the development of chitosan and poly(L-lactide) (PLLA) scaffolds cross-linked using a mixture of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), n-hydroxysuccinimide (NHS), and chondroitin sulfate (CS) for cartilage tissue engineering applications. Chitosan and PLLA were varied in concentration for developing scaffolds and prepared by freeze-drying method. The various scaffolds were studied using scanning electron microscopy (SEM), porosity by mercury intrusion porosimeter, and the molecular interactions among polymers using Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) studies. Differential scanning calorimetry (DSC) was used to predict the thermal properties of the scaffolds. The mechanical properties of the scaffolds were studied using static mechanical tester. The ability of the scaffolds to support chondrocyte proliferation was also studied. The microscopy suggests that the pore size of the scaffolds varied with the composition in the range of 38-172 μm and the porosities in the range of 73-93%. The XRD and the FTIR studies suggested that an alternation in the composition of the scaffolds altered the molecular interactions among the scaffold components. An increase in the chitosan content enhanced the swelling property. The degradation of the scaffolds was least when the proportion of chitosan and PLLA was in the ratio of 70:30. The in vitro cell proliferation study suggested that the developed scaffolds were able to support chondrogenesis, the glycosaminoglycan (GAG) content of the mature chondrocyte was 40 μg/ml and the viability was approximately 90%. Hence, the so designed scaffolds may be tried for cartilage tissue engineering applications.

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Fluorescent PLLA-nanodiamond composites for bone tissue engineering

Cited by 374 publications

References 35 publications

Properties and medical applications of polylactic acid: A review

Properties and medical applications of polylactic acid: A review

Reducing posttreatment relapse in cleft lip palatal expansion using an injectable estrogen–nanodiamond hydrogel

Evaluation of poly(L-lactide) and chitosan composite scaffolds for cartilage tissue regeneration

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