Fluorescent polymeric nanovehicles for neural stem cell modulation

Papadimitriou, Sofia; Robin, Mathew P.; Ceric, Dario; O’Reilly, Rachel K.; Marino, Silvia; Resmini, Marina

doi:10.1039/c6nr06440j

Cited by 23 publications

(17 citation statements)

References 42 publications

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“…Our group has been interested in NIPAM-based nanogels prepared by HDRP for a diverse range of applications, from drug delivery vehicles to sensors, due to their high solubility, colloidal stability, and biocompatibility [25], together with thermoresponsive properties [6,26,27,28]. Recently, we investigated the morphological changes resulting from variations in chemical structure of functional monomers and crosslinker content in a library of NIPAM and other acrylamide-based nanogels [6].…”

Section: Introductionmentioning

confidence: 99%

Covalently Crosslinked Nanogels: An NMR Study of the Effect of Monomer Reactivity on Composition and Structure

et al. 2019

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Covalently crosslinked nanogels are widely explored as drug delivery systems and sensors. Radical polymerization provides a simple, inexpensive, and broadly applicable approach for their preparation, although the random nature of the reaction requires careful study of the final chemical composition. We demonstrate how the different reactivities of the monomers influence the total degree of incorporation into the polymer matrix and the role played by the experimental parameters in maximizing polymerization efficiency. Nanogels based on N-isopropylacrylamide, N-n-propylacrylamide, and acrylamide crosslinked with N,N’-methylenebisacrylamide were included in this study, in combination with functional monomers N-acryloyl-l-proline, 2-acrylamido-2-methyl-1-propanesulfonic acid, and 4-vinyl-1H-imidazole. Total monomer concentration and initiator quantities are determining parameters for maximizing monomer conversions and chemical yields. The results show that the introduction of functional monomers, changes in the chemical structure of the polymerizable unit, and the addition of templating molecules can all have an effect on the polymerization kinetics. This can significantly impact the final composition of the matrices and their chemical structure, which in turn influence the morphology and properties of the nanogels.

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Section: Introductionmentioning

confidence: 99%

Covalently Crosslinked Nanogels: An NMR Study of the Effect of Monomer Reactivity on Composition and Structure

et al. 2019

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“…Among the different matrices, polymeric nanogels have been widely investigated 22 since they were first reported in 1935, 23 owing to their cargo-releasing applications. 24 The swelling properties in water and the stability of the crosslinked matrix are key features that offer advantages in terms of cargo loading capacity, compared to self-assembled systems. 25 These are complemented by the formation of stable colloidal solutions and the possibility of tailoring their physico-chemical properties by changing the chemical composition.…”

Section: Introductionmentioning

confidence: 99%

An l-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

Salinas

Resmini

2018

Polym. Chem.

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The synthesis and characterisation of a novel dual stimuli-responsive nanogel, based on thermoresponsive N-n-propylacrylamide and an L-proline based monomer acting as a pH-switcher, is reported here. The effect of the crosslinker/co-monomer ratios was studied to demonstrate the relationship between the chemical structure, degree of hydrophobicity and physico-chemical characteristics of the nanogels. Tailoring of the thermoresponsive properties was achieved by altering crosslinker N,N'-methylenebis (acrylamide) content between 10 and 50 mol%, in combination with three thermoresponsive monomers N-n-isopropylacrylamide, N-n-propylacrylamide and N-acryloylpyrrolidine. A library of 25 different combinations of monomers and crosslinkers was obtained and characterised by dynamic light scattering and UV-Vis spectroscopy. The nanogel based on N-n-propylacrylamide and 10 mol% crosslinker was then co-polymerised with an L-proline based monomer to introduce a pH-switch. This nanogel was obtained with <10 nm particle size and a VPTT ca. 43°C, and was used to demonstrate a drug delivery capability using Nile Blue A as a model drug. Detailed studies demonstrated maximum drug release at lower pH and 43°C, thus confirming the dual stimuli switch.

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“…Such stimulus‐responsive materials have been discussed for drug delivery applications for some time. The change of temperature may cause disintegration, shrinkage, or aggregation of drug carriers, which consequently leads to the release of the loaded drug …”

Section: Introductionmentioning

confidence: 99%

ABA and BAB Triblock Copolymers Based on 2‐Methyl‐2‐oxazoline and 2‐n‐Propyl‐2‐oxazoline: Synthesis and Thermoresponsive Behavior in Water

Zahoranová

Mrlík

Tomanová

et al. 2017

Macro Chemistry & Physics

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Inspired by the well‐known amphiphilic block copolymer platform known as Pluronics or poloxamers, a small library of ABA and BAB triblock copolymers comprising hydrophilic 2‐methyl‐2‐oxazoline (A) and thermoresponsive 2‐n‐propyl‐2‐oxazoline (B) is synthesized. These novel copolymers exhibit temperature‐induced self‐assembly in aqueous solution. The formation and size of aggregates depend on the polymer structure, temperature, and concentration. The BAB copolymers tend to agglomerate in water, with the cloud point temperature depending on the length of poly(2‐n‐propyl‐2‐oxazoline) chain. On the other hand, ABA copolymers form smaller aggregates with hydrodynamic radius from 25 to 150 nm. The dependence of viscosity and viscoelastic properties on the temperature is also studied. While several Pluronic block copolymers are known to form thermoreversible hydrogels in the concentration range 20–30 wt%, thermogelation is not observed for any of the investigated poly(2‐oxazoline)s at the investigated temperature range from 10 to 50 °C.

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Fluorescent polymeric nanovehicles for neural stem cell modulation

Cited by 23 publications

References 42 publications

Covalently Crosslinked Nanogels: An NMR Study of the Effect of Monomer Reactivity on Composition and Structure

Covalently Crosslinked Nanogels: An NMR Study of the Effect of Monomer Reactivity on Composition and Structure

An l-proline based thermoresponsive and pH-switchable nanogel as a drug delivery vehicle

ABA and BAB Triblock Copolymers Based on 2‐Methyl‐2‐oxazoline and 2‐n‐Propyl‐2‐oxazoline: Synthesis and Thermoresponsive Behavior in Water

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