Fluorescent Self-Healing Carbon Dot/Polymer Gels

Bhattacharya, Sagarika; Phatake, Ravindra S.; Nabha-Barnea, Shiran; Zerby, Nicholas; Zhu, Jun‐Jie; Shikler, Rafi; Lemcoff, N. Gabriel; Jelinek, Raz

doi:10.1021/acsnano.8b07087

Cited by 99 publications

(143 citation statements)

References 58 publications

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“…[ 30,43–48 ] Besides, Jelinek et al synthesized self‐healing gels through cross‐linking reaction between CDs and polyethylenimine. [ 49 ] However, as far as we know, CDs‐based COFs have not been reported yet, although they are conceptually practicable.…”

Section: Introductionmentioning

confidence: 99%

Carbon Dots Based Nanoscale Covalent Organic Frameworks for Photodynamic Therapy

Chen

Sun

Zheng

et al. 2020

Adv Funct Materials

114

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Covalent organic frameworks (COFs) have attracted much attention for various applications, while developing COFs with biomedical functions remains a big challenge. Most COFs are built purely from organic molecules, no carbon dots (CDs)-based COFs have been exploited to date. In this work, diamine molecules p-phenylenediamine and BODIPY are selected as model monomers to react with aldehyde-containing CDs and construct nanoscale COFs, named CCOF-1 and CCOF-2, respectively. After the modification with poly(ethylene glycol) (PEG), the formed CCOF-1@PEG and CCOF-2@PEG are stable and well-dispersible in aqueous media. The merits of CCOF-2@ PEG containing favorable physiological stability, good biocompatibility, and strong reactive oxygen species generation ability enable it to act as an excellent photodynamic therapy (PDT) agent for tumor treatment. The high PDT therapeutic efficiency for inhibiting cell proliferation and tumor growth was well shown by in vitro and in vivo experiments. This work demonstrates a new strategy for fabricating functional COF-based platforms for biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Carbon Dots Based Nanoscale Covalent Organic Frameworks for Photodynamic Therapy

Chen

Sun

Zheng

et al. 2020

Adv Funct Materials

114

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“…Even so, intrinsic healing materials, capable of healing under ambient conditions are generally soft and deformable and mostly in the form of hydrogels or elastomers that feature high polymer chain mobility/flexibility. 6,23,25,[33][34][35][36][37][38][39][40][41][42] Unfortunately, it is a formidable challenge to fabricate high-strength and stiff polymeric materials that could heal damages intrinsically under ambient conditions. This is because the diffusion of the polymer chains in rigid materials is hindered significantly, and the rigidity is not favorable for the intimate contact between fractured interfaces.…”

Section: Introductionmentioning

confidence: 99%

Mechanically Strong and Highly Stiff Supramolecular Polymer Composites Repairable at Ambient Conditions

Zhu

Chen

et al. 2020

CCS Chem

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It is a formidable challenge to fabricate healable polymeric materials with high mechanical strength and stiffness due to the highly suppressed diffusion of their polymer chains. Herein, a high-strength, highly stiff, and repairable/healable supramolecular polymer composite was fabricated by complexing poly(acrylic acid) (PAA) and poly(allylamine hydrochloride) (PAH) in aqueous solutions, followed by molding into desired shapes. Exquisitely tuning the electrostatic and H-bonding interactions between PAA and PAH led to associative phase-separation and in situ formation of nanostructures in the resultant PAA-PAH composites. The H-bonded assembly of PAA-PAH complexes existed as nanospheres were dispersed homogeneously in the continuous phase as an electrostatic assembly of PAA-PAH complexes. Such a structural feature endowed the PAA-PAH copolymer with a doublecross-linked structure, enabling significant reinforcement of the material. a The PAA-PAH composites exhibited a tensile strength and an elastic modulus as high as ∼ 67 MPa and ∼ 2.0 GPa, respectively. Due to the benefits from the reconstruction of the complexes, such as reversible electrostatic interactions and H-bonds between PAA and PAH, the PAA-PAH composite could be repaired/healed readily under ambient conditions (25°C, 40% humidity) by using the liquid-like form of the PAA-PAH complexes (i.e., coacervate). The healing strategy reported here provides a supplementary method for easy repair or healing of high-strength and stiff supramolecular polymer materials.

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“…In the recent past, some prospective strategies were adopted to prevent aggregation induced self-quenching in CDs for developing various functional materials. [36][37][38][39][40] In a seminal report, Zhou and co-workers 36 introduced CD based hybrid nanogel to avoid aggregation induced unwanted perturbation in fluorescence signal, where CDs were physically deposited in a polymeric gel network, and such a material was further extended for both bioimaging and drug delivery applications. Again, condensation reaction was adopted to prepare selfstanding silica based gel, where luminescent carbon dots were covalently crosslinked with appropriate orthosilicate to prevent aggregation-induced luminescence quenching of CDs in solid state.…”

Section: Introductionmentioning

confidence: 99%