Fluorescent Sulfur-Tagged Europium(III) Coordination Polymers for Monitoring Reactive Oxygen Species

Abstract

Oxidative stress caused by reactive oxygen species (ROS) is harmful to biological systems and implicated in various diseases. A variety of selective fluorescent probes have been developed for detecting ROS to uncover their biological functions. Generally, the preparation of the fluorescent probes usually undergoes multiple synthetic steps, and the successful fluorescent sensing usually relies on trial-and-error tests. Herein we present a simple way to prepare fluorescent ROS probes that can be used both in biological and environmental systems. The fluorescent europium(III) coordination polymers (CPs) are prepared by simply mixing the precursors [2,2'-thiodiacetic acid and Eu(NO3)3·6H2O] in ethanol. Interestingly, with the increase of reaction temperature, the product undergoes a morphological transformation from microcrystal to nanoparticle while the structure and fluorescent properties retain. The fluorescence of the sulfur-tagged europium(III) CPs can be selectively quenched by ROS, and thus, sensitive and selective monitoring of ROS in aerosols by the microcrystals and in live cells by the nanoparticles has been achieved. The results reveal that the sulfur-tagged europium(III) CPs provide a novel sensor for imaging ROS in biological and environmental systems.

Lanthanide-based metal-organic framework nanosheets with unique fluorescence quenching properties for two-color intracellular adenosine imaging in living cells

“…The structures of the crystalline MOF-Ln samples were monitored by powder X-ray diffraction. As shown in Figure 1a, the crystalline MOFTb corresponded well with MOF-Eu {[Eu 2 (TDA) 3 ]·2H 2 O}, which was prepared in our previous work 28 (Figure 1b), but differed from MOFLa and MOF-Nd. This difference in structures of MOF-Ln samples might result from the lanthanide contraction.…”

Insight into the Unique Fluorescence Quenching Property of Metal-Organic Frameworks upon DNA Binding

“…26−28 As the size of MOFs decrease down to nanoscale, the metal ions and organic ligands on the surface of NMOFs will not be fully coordinated, leading to the NMOFs carrying different charges. 29 Such charge properties of NMOFs will certainly affect their interaction with charged dye-labeled biomolecules due to the electrostatic interactions and in turn will affect the fluorescence quenching abilities of NMOFs toward dye-labeled biomolecules. 30 The relationship between the fluorescence quenching and surface properties of NMOFs will finally affect the performance of the established sensing platforms; however, study on this issue has not yet been reported.…”

Insights on Luminescent Micro‐ and Nanospheres of Infinite Coordination Polymers

“…H 2 O 2 sensing using ICPs was reported by Wang et al The group synthesized luminescent ICPs based on 2,2'-thiodiacetic acid (TDA) and Eu 3 + in ethanol solvent. [79] By changing the reaction temperature, the authors could obtain microcrystals (25 °C) or spherical nanoparticles (150 °C). H 2 O 2 sensing experiments were carried out both in solution and in vitro.…”