2022
DOI: 10.3389/fnmol.2022.958222
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Fluorescent transgenic mouse models for whole-brain imaging in health and disease

Abstract: A paradigm shift is occurring in neuroscience and in general in life sciences converting biomedical research from a descriptive discipline into a quantitative, predictive, actionable science. Living systems are becoming amenable to quantitative description, with profound consequences for our ability to predict biological phenomena. New experimental tools such as tissue clearing, whole-brain imaging, and genetic engineering technologies have opened the opportunity to embrace this new paradigm, allowing to extra… Show more

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Cited by 4 publications
(1 citation statement)
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“…Cre-loxP and Flp-FRT are site-specific recombinase (SSR) systems widely used in GEMMs. The combination of Cre-/Flp -expressing mouse strains with recombinase-dependent reporters or effectors has proven as a versatile and efficient approach offering a myriad of options ranging from manipulation of gene expression and cell activity to visualization of molecules, cells and circuits ( Deussing, 2013 ; Luo et al, 2018 ; Arias et al, 2022 ).…”
Section: Introductionmentioning
confidence: 99%
“…Cre-loxP and Flp-FRT are site-specific recombinase (SSR) systems widely used in GEMMs. The combination of Cre-/Flp -expressing mouse strains with recombinase-dependent reporters or effectors has proven as a versatile and efficient approach offering a myriad of options ranging from manipulation of gene expression and cell activity to visualization of molecules, cells and circuits ( Deussing, 2013 ; Luo et al, 2018 ; Arias et al, 2022 ).…”
Section: Introductionmentioning
confidence: 99%