Fluoride and bone

Faccini, J. M.

doi:10.1007/bf02058641

Cited by 80 publications

(18 citation statements)

References 51 publications

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“…Tetracyclines were introduced in 1948 as broad-spectrum antibiotics that may be used in the treatment of common infections in children and adults [25]. The use of low dose tetracycline as a histological bone marker has been well established since the 1960s with papers by Bevelander et al, [12], Ibsen and Urist [13], Faccini [14], Frost [15], and more recently by Ranggard [11], Engstrom [16], Sun et al, [17]. It was discovered that tetracycline is incorporated into hard tissues calcifying at the time of their administration and subsequently could be studied in undecalcified sections by fluorescence microscopy [12,14].…”

Section: Discussionmentioning

confidence: 99%

Histological preparation of teeth and tooth growth

Williamson¹

2015

Oral Biol Dent

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Section: Discussionmentioning

confidence: 99%

Histological preparation of teeth and tooth growth

Williamson¹

2015

Oral Biol Dent

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“…The most widely accepted concept (Faccini, 1969) of the action of fluoride is that, with the formation of fluorapatite crystals in bone, decreased solubility results in an inhibition of bone resorption. This, in turn, results in secondary hyperparathyroidism, presumably to maintain calcium homeostasis.…”

Section: Discussionmentioning

confidence: 99%

“…However, the exact mechanism leading to the involvement of the parathyroid glands in skeletal fluorosis is unclear. The incorporation of fluoride in bone results in the formation of fluorapatite and improved mineral crystallinity leading to reduced chemical reactivity and solubility of the bone mineral (Faccini, 1969). I t has been suggested that the decreased crystal solubility results in an inhibition of bone resorption and a drop in the serum calcium concentration, thus stimulating parathyroid hormone secretion in order to maintain calcium homeostasis (Rich and Feist, 1970).…”

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confidence: 98%

Fluoride stimulation of the rat parathyroid gland: An ultrastructural study

Ream

Principato

1981

Am. J. Anat.

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The parathyroid glands of rats given 150 ppm fluoride in the drinking water for 10 weeks are evaluated ultrastructurally and compared to the parathyroid glands of untreated rats. As a result of fluoride ingestion, the majority of the parathyroid cells are dark chief cells, indicating that these cells are in the active stages of the secretory cycle. More significantly, in the fluoride-treated rats, the cytoplasmic organelles of the dark chief cells are even more developed that those seen in the dark chief cells of untreated rats. The dark cells contain an electron-dense cytoplasm with abundant lamellar arrays of rough endoplasmic reticulum, spiral aggregations of free ribosomes, multiple dilated Golgi complexes, and increased numbers of secretory granules. The cells are at a minimum dimension with maximum tortuosity of the plasma membranes; and, as a result, large intercellular spaces are often seen between contiguous cells. Based on these observations, it is suggested that, in the fluoride-treated rat, a type of secondary hyperparathyroidism develops resulting in an increase in the organelles involved in protein synthesis and secretion.

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“…However, a number of agents--such as estrogen [4][5][6], diphosphonate [7][8][9], vitamin D [10][11][12][13][14][15][16], fluoride [17], calcium [18], inorganic phosphate [19], and calcitonin [20][21][22]--have been tried.…”

mentioning

confidence: 99%

Immobilization osteoporosis and active vitamin D: Effect of active vitamin D analogs on the development of immobilization osteoporosis in rats

et al. 1981

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The therapeutic effects of vitamin D analogs, 1,24(R)-dihydroxycholecalciferol [1,24(R)-(OH)2D3], 1,24(S)-dihydroxycholecalciferol [1,24-(S)(OH)2D3], and 1,25-dihydroxycholecalciferol [1,25(OH)2D3] on immobilization osteoporosis were studied in rats. The right hind limb was immobilized through application of a plaster cast following the section of the sciatic nerve. The left hind limb was intact. Vitamin D analogs were orally administered for 6 weeks at dose levels of 0.02 and 0.10 micrograms/kg/day, respectively. The mean lengths of the immobilized femurs were not significantly different from those of the intact femurs in all the experimental groups. In the immobilized femur of animals treated with 1,24(R)(OH)2D3, 0.10 micrograms/kg, dry and ash weights were heavier and calcium and phosphorus contents greater than those in the nontreated group. Furthermore, the amount of calcified bone mass and the cortical thickness of the femurs of the immobilized limb in 1,24(OH)2D3-treated animals were greater than those in the nontreated animals. Treatment with 1,25(OH)2D3 at 0.10 micrograms/kg caused an increase of the bone mass in both immobilized and intact femurs when compared with those of the control group. It was concluded that the administration of 1,24(R)(OH)2D3 diminished the effect of immobilization in the development of osteoporosis without any side effects.

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Fluoride and bone

Cited by 80 publications

References 51 publications

Histological preparation of teeth and tooth growth

Histological preparation of teeth and tooth growth

Fluoride stimulation of the rat parathyroid gland: An ultrastructural study

Immobilization osteoporosis and active vitamin D: Effect of active vitamin D analogs on the development of immobilization osteoporosis in rats

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