2011
DOI: 10.1111/j.1365-2591.2011.01907.x
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Fluoride-containing nanoporous calcium-silicate MTA cements for endodontics and oral surgery: early fluorapatite formation in a phosphate-containing solution

Abstract: The addition of sodium fluoride accelerated apatite formation on calcium silicate cements. Fluoride-doped calcium silicate cements had higher bioactivity and earlier formation of fluorapatite. Sodium fluoride may be introduced in the formulation of mineral trioxide aggregate cements to enhance their biological behaviour. F-doped calcium silicate cements are promising bone cements for clinical endodontic use.

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Cited by 47 publications
(47 citation statements)
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“…In phosphate‐containing solutions, sodium fluoride added calcium silicate cements showed higher calcium ion release than calcium silicate cements, which results in improved bioactivity due to fluorapatite formation (Gandolfi et al . ). Gandolfi et al .…”
Section: Discussionmentioning
confidence: 97%
“…In phosphate‐containing solutions, sodium fluoride added calcium silicate cements showed higher calcium ion release than calcium silicate cements, which results in improved bioactivity due to fluorapatite formation (Gandolfi et al . ). Gandolfi et al .…”
Section: Discussionmentioning
confidence: 97%
“…Although the final compressive strength for MTA is reported to be approximately 70 MPa, which is relatively high compared with other injectable systems, the setting time is long (~4 h) and the setting reaction is highly alkaline, reaching up to pH values of 12.5 [56,57] towards the beginning of the reaction and decreasing to pH 8.5 by day 28 [57]. Traditional MTAs have been shown to form surface apatite when immersed in simulated body fluid and other phosphatecontaining solutions [60], and have been demonstrated to support the in vitro differentiation of human orofacial bone mesenchymal stem cells [61].…”
Section: Calcium Silicate Cementsmentioning
confidence: 98%
“…In particular, mineral trioxide aggregate (MTA) is a CSiC that has been approved by the US FDA since the late 1990s for dental pulp repair. MTA consists of tricalcium silicate, dicalcium silicate, tricalcium aluminate (TCA), tetracalcium aluminoferrite and calcium sulfate, with bismuth oxide as the radiopacifying agent, and when all of the constituents are mixed with water, it forms a paste that can be molded to fit the site of implantation [56,57].…”
Section: Calcium Silicate Cementsmentioning
confidence: 99%
“…However, little attention has been paid so far to the biocompatibility testing of MTA supplied with additives (Karygianni et al 2016), which furthermore have not been selected according to their cell-or tissue-supporting capabilities. All of these requests are met by fluoride (Everett 2011, Lee et al 2017, thus rendering it an attractive candidate for the development of a new MTA cement (Gandolfi & Prati 2010, Gandolfi et al 2011. All of these requests are met by fluoride (Everett 2011, Lee et al 2017, thus rendering it an attractive candidate for the development of a new MTA cement (Gandolfi & Prati 2010, Gandolfi et al 2011.…”
Section: Introductionmentioning
confidence: 99%