2020
DOI: 10.1007/s12011-020-02362-x
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Fluoride-Induced Expression of Neuroinflammatory Markers and Neurophysiological Regulation in the Brain of Wistar Rat Model

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Cited by 24 publications
(11 citation statements)
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“…Rats that have been chronically exposed to sodium fluoride exhibited higher expression of cyclooxygenase COX2, vascular endothelial growth factor (VEGF), and heat shock protein-70 (HSP-70), which act as markers of neuroinflammation. This relationship appeared to be dose dependent [ 20 ]. Additional rat data have indicated that cyclooxygenases, including COX1 and COX2, were reduced in the brains of rats that had been subject to chronic fluoride exposure.…”
Section: Resultsmentioning
confidence: 99%
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“…Rats that have been chronically exposed to sodium fluoride exhibited higher expression of cyclooxygenase COX2, vascular endothelial growth factor (VEGF), and heat shock protein-70 (HSP-70), which act as markers of neuroinflammation. This relationship appeared to be dose dependent [ 20 ]. Additional rat data have indicated that cyclooxygenases, including COX1 and COX2, were reduced in the brains of rats that had been subject to chronic fluoride exposure.…”
Section: Resultsmentioning
confidence: 99%
“…Fluoride consumption may also impact neurotransmitter levels [ 20 ]. Serotonin levels have been shown to significantly increase in the brains of rats following fluoride exposure Notably, between 60–100 ppm of NaF, increases in serotonin have been observed at an above dose-dependent level.…”
Section: Resultsmentioning
confidence: 99%
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