Fluoride Toxicity in Human 10.14511/jlm.2013.010203 s: Effect on Serum and Plasma Enzyme Levels in Endemic Areas of Krishnagiri District of Tamilnadu, India

Pratheebaa, P.; Dhivyalakshmi, S.; Shankar, Priyanka; Karthick, N.; Palvannan, Thayumanavan

doi:10.14511/jlm.2013.010203

Cited by 5 publications

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“…The present in vitro study has importance in the public health area where human beings are exposed to F through drinking water. Different studies involving human subjects clearly showed that F in drinking water affected male reproduction (Ortiz-Perez et al, 2003; Pratheebaa et al, 2013). Current investigation provides direct evidence for F-induced toxicity on male reproduction, where minimum concentrations of NaF (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, F is also known to affect reproductive function (Gupta et al, 2007; Zhou et al, 2013). Numerous studies have established a close relationship between fluorosis and infertility in animal models as well as in human beings (Chinoy and Narayana, 1994; Ortiz-Perez et al, 2003; Pratheebaa et al, 2013). The study of effects of F on reproduction began in the 1970s with the observation of calcification of the vas deferens in a patient with endemic fluorosis (Teotra and Teotra, 1972).…”

Section: Introductionmentioning

confidence: 99%

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Dose and time-dependent effects of sodium fluoride on sperm motility: An in vitro study

2018

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The present study was undertaken to investigate the toxic effects of sodium fluoride (NaF) on sperm motility and abnormality. Treatment of epididymal sperm suspensions with different doses of NaF (0.1, 1, 10, and 100 mg/ml) significantly reduced sperm motility at 15-and 30-min time intervals. Further, incubation at the same concentrations of NaF for 5-, 10-, and 15-min time intervals decreased sperm motility in a dose-and timedependent manner. The present investigation revealed for the first time the adverse effect of lower doses of NaF (0.1 mg/ml) on sperm motility. Further, higher doses of NaF (10 and 100 mg/ml) caused a complete loss of sperm motility with a concomitant increase in sperm abnormality, which reflected the toxic effect of NaF on spermatozoa and its capability in fertilization.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dose and time-dependent effects of sodium fluoride on sperm motility: An in vitro study

2018

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“…A study done by Pratheebaa P. et al showed that the enzymes ALT and ALP were positively correlated with the occurrence of fluoride, while AST, LDH, were negatively correlated with the existence of fluoride 20 . A cross-sectional study conducted by Xiong X et al suggested that excessive (i.e.42.0 mg/L) fluoride in drinking water may cause damage to children"s liver functions, which would aggravate as drinking water fluoride level increases 21 .…”

Section: Discussionmentioning

confidence: 98%

Effect of Fluorosis on Hepatic Enzymes in Human

Chatterjee¹,

Mahapatra²,

Chakrabarti³

et al. 2016

IOSR

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Fluorosis is a major public health problem in India. This cross-sectional observational study has been conducted in the fluoride endemic zones of Bankura district to evaluate the effect of fluorosis on the liver enzymes. This study was carried out in the Simlapal block of Bankura, on 100 subjects by using simple random sampling in which 50 were cases. The serum samples were collected from the subjects and serum fluoride was estimated by Ion-Meter and serum ALT, AST, ALP and LDH levels were determined by auto-analyzer and were compared with age and sex matched controls. The serum fluoride was found to have a statistically significant relationship with AST and ALP and serum LDH has also statistically significant relationship with ALT and AST in the study group. The serum levels of fluoride, ALT, AST, ALP and LDH were higher in the study group compared to the comparison group.

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“…Numerous studies in rat and animal models have shown the adverse effect of F on physiological systems (Gadallah, 2016; Gessner et al, 1994; Gupta et al, 1993; Shashi and Thapar, 2000; Singh et al, 2001; Zhao et al, 2014). Studies have reported the incidences of kidney stones (Doull et al, 2006; Juuti and Heinonen, 1980; Whitford, 1996), gastrointestinal effects, nausea, vomiting, diarrhea, abdominal pain (Gessner et al, 1994; Penman et al, 1997; Sidhu and Kimmer, 2002), myocardial infarction, impaired signaling, bone disorders (Pratheebaa et al, 2013), and diminished cognitive abilities (Lu et al, 2000; Wang et al, 2007; Xiang et al, 2003; Zhao et al, 1996) after the chronic ingestion of ground water F.…”

Section: Introductionmentioning

confidence: 99%

Time-dependent effect of ground water fluoride on motility, abnormality and antioxidant status of spermatozoa: An in vitro study

2019

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The present study was undertaken to investigate the toxic effect of ground water fluoride (F) on motility, abnormality, and antioxidant status of spermatozoa. Treatment of ground water F with epididymal sperm suspension caused complete loss of sperm motility and decrease in the activities of superoxide dismutase (SOD) and catalase (CAT) and increase in the concentration of malondialdehyde (MDA) and abnormality of spermatozoa at 15 and 30 min time intervals. Further, incubation of spermatozoa with ground water F for 5, 10, and 15 min time intervals significantly reduced the sperm motility and activities of SOD and CAT and increased the concentration of MDA and abnormality of spermatozoa. The study revealed that F-induced effect on sperm motility and antioxidant status is time dependent. Increase in oxidative stress and concomitant decrease in motility of spermatozoa in ground water F clearly indicates that F-induced oxidative stress affected the sperm motility. The present study for the first time demonstrated the toxic effect of ground water F on spermatozoa at shorter duration of exposure, which affects the capability of spermatozoa in fertilization.

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Fluoride Toxicity in Human 10.14511/jlm.2013.010203 s: Effect on Serum and Plasma Enzyme Levels in Endemic Areas of Krishnagiri District of Tamilnadu, India

Cited by 5 publications

References 0 publications

Dose and time-dependent effects of sodium fluoride on sperm motility: An in vitro study

Dose and time-dependent effects of sodium fluoride on sperm motility: An in vitro study

Effect of Fluorosis on Hepatic Enzymes in Human

Time-dependent effect of ground water fluoride on motility, abnormality and antioxidant status of spermatozoa: An in vitro study

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