Fluoride Uptake in vivo by Deciduous Enamel of Children from Neutral Fluoride and APF Mouthrinses

Mellberg, J.R.; Nicholson, C.R.

doi:10.1159/000260103

Cited by 22 publications

(7 citation statements)

References 6 publications

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“…A larger accumulation of plaque on teeth could inhibit fluoride uptake more from a dilute F rinse than from a relatively concentrated rinse. It is of interest to note here that an almost identical low fluoride uptake was observed from daily use of the same 0.02% F rinse in anoth er non-fluoride area [Mellberg and N icholson, 1973].…”

Section: Discussionsupporting

confidence: 58%

Fluoride Concentrations in Deciduous Teeth of Children Using Fluoride Mouthrinses

Mellberg¹,

Nicholson²,

Packer³

et al. 1973

Caries Res

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Analysis of exfoliated deciduous teeth from children living in both fluoridated and non-fluoridated areas and who used a 0.02% F rinse 5 times per week or a 0.1% F rinse one time per week revealed that significant fluoride was acquired only at a depth of 5 μm from the surface. Children who used the dilute F rinse in the non-fluoridated area acquired approximately one-third as much fluoride as teeth from the other groups. Enamel was not found to increase in fluoride concentration as more rinses were received but maintained the increase initially obtained.

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Section: Discussionsupporting

confidence: 58%

Fluoride Concentrations in Deciduous Teeth of Children Using Fluoride Mouthrinses

Mellberg¹,

Nicholson²,

Packer³

et al. 1973

Caries Res

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“…Because of the large standard deviations, this increase was not statistically significant (p > 0.25). This result appears to be in harmony with a previous in vivo study (Mellberg and Nicholson, 1974), which showed that rinses with a solution consisting of 200 ppm F at pH 7 did not significantly increase the permanentlybound fluoride content of the enamel.…”

Section: Discussionsupporting

confidence: 91%

“…Since these fluoride rinses do not substantially increase the enamel fluoride content on a long-term basis (Mellberg and Nicholson, 1974), the effectiveness of the rinse regimen appears to come from the relatively high levels of fluoride in the oral fluids produced by the frequent fluoride rinses.…”

Section: Introductionmentioning

confidence: 99%

Basic Biological Sciences

1985

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It has been shown in laboratory and animal studies that tooth enamel becomes considerably more reactive toward low levels of fluoride after receiving pre-treatment which forms dicalcium phosphate dihydrate (DCPD) in the enamel as an intermediate. This in vitro study was undertaken to determine the effect on human enamel fluoride uptake of incorporating DCPD-forming rinses into a conventional fluoride rinsing program. In one group, enamel samples received a one-minute rinse with 0.2% NaF each day for 20 days. Samples in the second group were treated identically, except that they were also given a one-minute DCPD-forming rinse prior to the first, sixth, eleventh, and sixteenth fluoride rinses. At the end of the rinsing program, all samples were washed in 1 M KOH to remove labile fluorides. The enamel biopsy data showed that the fluoride uptake resulting from 0.2% NaF alone was not statistically significant, whereas uptake produced by the DCPD-forming plus NaF rinses was significant. The results suggest that the DCPD-forming rinse may improve the efficacy of fluoride rinse programs.

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“…Other in vitro studies (Hong et al, 1985) and in vivo studies (Mellberg and Nicholson, 1974;Shern et al, 1984) have shown that repeated short applications of 0.2% NaF can cause incorporation of some permanently bound F into the enamel. Also consistent with the results of previous in vitro studies (Takagi et al, 1984;Hong et al, 1985) and in vivo studies (Shern et al, 1979;Chow et al, 1981;Shern et al, 1984) is the present finding that the experimental specimens, which received the same F regimen as did the controls plus a DCPD-forming treatment, incorporated much more F into the enamel than did the controls.…”

Section: Discussionmentioning

confidence: 98%

Enhanced Enamel F Uptake by Monocalcium Phosphate Monohydrate Gels

et al. 1987

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Application of DCPD-forming solutions has been shown to increase substantially the enamel reactivity toward F. The effectiveness of a variation of this treatment procedure, in which the DCPD-forming solution was replaced by a viscous carboxymethylcellulose gel containing monocalcium phosphate monohydrate (MCPM), was evaluated by use of 12 extracted human molars. The MCPM gel was highly effective in enhancing the F uptake by enamel. The mean F uptakes by teeth treated with MCPM gel, followed by exposure to a F solution, were 3972 (+/- 565), 2383 (+/- 312), and 1751 (+/- 313) ppm, respectively, in the outer 5-, 10-, and 15-microns depths in enamel. These uptakes were 2374, 1273, and 852 ppm more than those of the control teeth. Because the F solution was undersaturated with respect to CaF2, the F incorporated into the enamel was believed to be in apatitic form and not as CaF2. The MCPM gel has advantages over the DCPD-forming solution because (1) much longer gel-tooth contact times can be achieved, and (2) the treatment agent can readily be delivered to specific sites where the tooth needs the protection most.

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Fluoride Uptake in vivo by Deciduous Enamel of Children from Neutral Fluoride and APF Mouthrinses

Cited by 22 publications

References 6 publications

Fluoride Concentrations in Deciduous Teeth of Children Using Fluoride Mouthrinses

Fluoride Concentrations in Deciduous Teeth of Children Using Fluoride Mouthrinses

Basic Biological Sciences

Enhanced Enamel F Uptake by Monocalcium Phosphate Monohydrate Gels

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