Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies

Block, Eric; Bechand, Benjamin; Gundala, Sivaji; Vattekkatte, Abith; Wang, Kai; Mousa, Shaymaa S; Godugu, Kavitha; Yalçın, Murat; Mousa, Shaker A.

doi:10.3390/molecules22122081

Cited by 32 publications

(21 citation statements)

References 40 publications

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“…The amino acid composition analysis results of GP, GPH-P, and GPH-T are shown in Leu, Gly residues, and C-terminal peptides with Arg, Tyr, Phe, and Pro residues have significant antihypertensive effects (Block et al, 2017;Girgih, He, & Aluko, 2014;Tu, Wang, et al, 2018). According to the proportion of these kinds of amino acids in GPH-P and GPH-T, GP hydrolyzed with appropriate enzymes could…”

Section: Amino Acids Compositional Analysis Of Gp Gph-p and Gph-tmentioning

confidence: 99%

Antioxidant and antihypertensive effects of garlic protein and its hydrolysates and the related mechanism

Gao

Xue

et al. 2019

J Food Biochem

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Garlic protein (GP) was enzymatically hydrolyzed using pepsin and trypsin followed by the evaluation of antioxidant and angiotensin-converting enzyme (ACE) inhibitory activities of GP and its hydrolysates. The antihypertensive effects of GP and its hydrolysates were determined in vivo. The results showed that GP and its hydrolysates namely GPH-P (pepsin) and GPH-T (trypsin) possessed appreciable antioxidant and ACE inhibitory activities. The ACE inhibitory activity of GP, GPH-T, and GPH-P was in consistent with their antioxidant activities. GP and its hydrolysates offered significant protective effects against H 2 O 2 -induced oxidative damage (p < .05). In addition, the administration of GP, GPH-T, and GPH-P reduced the blood pressure in hypertensive rats. The mechanism might be to reduce blood pressure by inhibiting the activity of ACE, reducing the formation of ACEII, and protecting the activity of bradykinin. This study suggested that GP might be utilized as a promising functional food as antioxidant and antihypertensive agents. Practical applicationsGarlic (Allium sativum L.) is one of the oldest cultivated plants that belongs to the Liliaceae family and it has been used in cooking and medicinal applications. Large quantities of garlic residuals were produced with the development of the garlic essential oil industry. These residuals are highly rich in proteins and they can be used for the preparation of protein hydrolysates. Generally, hydrolysates are considered as a promising food supplement due to the enrichment of amino acids present in it.In this study, garlic proteins (GPs) and its hydrolysates retain effective antioxidant effects. They were found to reduce the blood pressure and prevent oxidative stress induced by H 2 O 2 . The information from this study could be used to develop a new nutritional supplement from GP and its hydrolysates to treat hypertension as well as prevent oxidative damage. K E Y W O R D SACE inhibitory activity, antioxidant, L02 cells, oxidative damage

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Section: Amino Acids Compositional Analysis Of Gp Gph-p and Gph-tmentioning

confidence: 99%

Antioxidant and antihypertensive effects of garlic protein and its hydrolysates and the related mechanism

Gao

Xue

et al. 2019

J Food Biochem

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“…Research has revealed that allicin targets multiple pathways implied in the inhibition of cancer development [27], including cell cycle arrest [21,28], the induction of apoptosis [29][30][31][32][33][34], the induction of histone acetylation [35] and the inhibition of angiogenesis [36]. Some of these studies dealing with the induction of apoptosis by allicin have also been reported for Caco-2 and HT-29 [20,34,37].…”

Section: Discussionmentioning

confidence: 99%

Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer

Pérez‐Ortiz

Moya

Cruz-Morcillo

et al. 2020

IJMS

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In this work, we sought to investigate the effects of a thiosulfinate-enriched garlic extract, co-administered with 5-fluorouracil (5-FU) or oxaliplatin chemotherapy, on the viability of colon cancer cells (Caco-2 and HT-29). We also addressed the economic feasibility of a new combined treatment of this thiosulfinate-enriched garlic extract, with oxaliplatin that could reduce the dosage and costs of a monotherapy. The thiosulfinate-enriched garlic extract not only enhanced the impact of 5-FU and oxaliplatin (500 µM) in decreasing Caco-2 and HT-29 viability, but also showed a higher effect than standard 5-FU and oxaliplatin chemotherapy as anti-cancer agents. These results provided evidences for the combination of lyophilized garlic extract and 5-FU or oxaliplatin as a novel chemotherapy regimen in colon cancer cells that may also reduce the clinical therapy costs.

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“…berichteten über die biomimetische thermische Umlagerung von Allicin in wässrigem Aceton (Schema ) . Kürzlich wurde diese Synthese zu einem trifluorierten Analogon erweitert . Obwohl die Synthese eine Eintopfreaktion darstellt, ist die Ausbeute mit 34 % recht niedrig.…”

Section: Methodsunclassified

Eine kurze Totalsynthese von Ajoen

Silva

Khokhar²,

Williams³

et al. 2018

Angewandte Chemie

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Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies

Cited by 32 publications

References 40 publications

Antioxidant and antihypertensive effects of garlic protein and its hydrolysates and the related mechanism

Antioxidant and antihypertensive effects of garlic protein and its hydrolysates and the related mechanism

Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer

Eine kurze Totalsynthese von Ajoen

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