Fluorinated bovine hydroxyapatite: preparation and characterization

Murugan, R.; Kumar, T.S. Sampath; Rao, K. Panduranga

doi:10.1016/s0167-577x(02)00805-4

Cited by 68 publications

(51 citation statements)

References 12 publications

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“…While synthetic apatite is a promising candidate for ionic substitutions, biological apatite is the preferred choice as it inherently possesses marked similarities with the human bone in terms of crystallographic properties, chemical composition, porosity, and a resorption rate which matches the bone formation rate 3,14,20,[25][26][27] . Amongst the foreign ions used to enhance the biological performance of implanted materials, fluoride has aroused great interest since a low dose of fluoride was reported to stimulate bone formation and increase bone mass without causing any mineralization defects 28) .…”

Section: Ion Incorporationmentioning

confidence: 99%

“…Both chemical and thermal approaches have been used to prepare biological HA derived from animal bones 14,24,30,31) . Thermal treatment has several advantages: it is the only means to eliminate organic matter 32) and it decreases the risk of disease transmission and immunoreactivity 30) .…”

Section: Synthesis Of Fluorinated Phamentioning

confidence: 99%

“…However, among the frequently used animal bones, porcine bone bears the closest resemblance to human bone in terms of bone macrostructure and microstructure, bone composition, and bone remodeling rate 5) . Numerous studies were carried out on ion incorporation (e.g., F − , Mg 2+ , Sr 2+ , CO3 2− ) into synthetic apatite [6][7][8][9][10][11][12] and biological apatite (such as bovine bone, natural coral, or cuttlefish bone) 3,[13][14][15][16] . In general, these studies showed that ion-incorporated hydroxyapatite composites were promising candidates for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

“…A numbers of studies have been carried out on fluoride-incorporated synthetic HA 11,[19][20][21] , but information remains scarce on the preparation and characteristics of fluorinated biological HA 14) . Moreover, the preparation processes previously reported for fluorinated biological HA 14) seemed too complicated on the one hand, and the characterization efforts lacking in thoroughness on the other hand.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the preparation processes previously reported for fluorinated biological HA 14) seemed too complicated on the one hand, and the characterization efforts lacking in thoroughness on the other hand. The purpose of this study was to prepare fluorinated porcine hydroxyapatite (FPHA) using straightforward chemical and thermal processes, followed by a thorough investigation into its morphological and physicochemical characteristics.…”

Section: Introductionmentioning

confidence: 99%

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Preparation and characterization of fluorinated porcine hydroxyapatite

Liu

Chen

et al. 2012

Dent. Mater. J.

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Simple chemical and thermal treatments were applied to prepare fluorinated porcine hydroxyapatite (FPHA). Morphology of FPHA was observed using SEM. Physiochemical characteristics, namely crystalline phase, chemical composition, functional groups, and binding energy of fluorine were investigated using XRD, EDX, FTIR, and XPS respectively. Concentration of free fluoride ion released from FPHA in HCl solution (pH 3.0-4.0) was detected using a fluoride ion concentration meter. SEM, XPS, XRD, and FTIR results confirmed the fluorination of porcine hydroxyapatite (PHA). Significant crystal morphological difference was observed between PHA and FPHA. Concentration of free fluoride ion released from FPHA increased with rising concentration of immersion solution and length of immersion period. Fluoride was successfully incorporated into PHA by chemical and thermal processes in this study. Fluoride incorporation rate into PHA was a strong function of the fluorine concentration in the immersion solution.

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Section: Ion Incorporationmentioning

confidence: 99%

Section: Synthesis Of Fluorinated Phamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation and characterization of fluorinated porcine hydroxyapatite

Liu

Chen

et al. 2012

Dent. Mater. J.

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Nanophase Biomaterials for Tissue Engineering

Ramalingam

Ramakrishna

2003

Nanotechnologies for the Life Sciences

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The sections in this article are Introduction: Problems with Current Therapies Tissue Engineering: A Potential Solution Stem Cells: The Essentials Nanobiomaterials: A New Generation Scaffolding Material Characteristics of Scaffold Types of Scaffolding Materials Ceramic Nanobiomaterials Polymeric Nanobiomaterials Nanofibrous Scaffold Processing: Current Scenarios Self‐assembly Phase Separation Electrospinning – A New Approach Experimental System Spinning Mechanism Electrospun Nanofibrous Scaffolds Cell–Matrix (Scaffold) Interactions Cell–Ceramic Scaffold Interactions Cell–Polymer Scaffold Interactions Concluding Remarks Acknowledgments

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Initial observations of dynamically heated bone

Greenwood

Rogers

Beckett

et al. 2013

Crystal Research and Technology

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dynamically heated bone, lattice parameters.Understanding the chemical changes within bone during heat treatment has become essential within many fields including biomaterials, archaeology and forensic science. All current approaches report the systematic heating and cooling of bone specimens (a 'static' approach). These provide information on modifications to mineral structure and chemistry including recrystallisation and thermal decomposition from bone specimens cooled to room temperature. In order to understand these fundamental processes further, we adopted, for the first time, a dynamic heating protocol coupled to an X-ray diffraction probe, which provides in situ analysis at temperature. This approach allows physico-chemical processes to be observed at elevated temperatures for five different bone types: bovine, porcine, human, rostrum and red deer antler. The results, when compared to static heating studies, illustrate individually the effects of heating and cooling upon bone mineral. On heating, the onset of recrystallisation occurs rapidly over a short temperature range for all bone types. It is proposed the continued growth of the hydroxyapatite crystals is limited by the mineral to organic ratio. Investigation of the lattice parameters has also indicated significant differences between the bone types, suggesting species differentiation is possible using X-ray diffraction analysis. Statistical analysis of the 'a' axis lattice parameter data revealed human bone is distinguishable from the other bone types.

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Fluorinated bovine hydroxyapatite: preparation and characterization

Cited by 68 publications

References 12 publications

Preparation and characterization of fluorinated porcine hydroxyapatite

Preparation and characterization of fluorinated porcine hydroxyapatite

Nanophase Biomaterials for Tissue Engineering

Initial observations of dynamically heated bone

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