Fluorine-18-labeled Gd3+/Yb3+/Er3+ co-doped NaYF4 nanophosphors for multimodality PET/MR/UCL imaging

Zhou, Jing; Yu, Mengxiao; Sun, Yun; Zhang, Xianzhong; Zhu, Xingjun; Wu, Zhanhong; Wu, Dongmei; Li, Fuyou

doi:10.1016/j.biomaterials.2010.09.071

Cited by 391 publications

(270 citation statements)

References 38 publications

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“…In a previous study, we reported facile synthesis of small, hexagonal NaGdF 4 :Yb 31 /X 31 (X 5 Er or Tm) UCNPs and their magnetic resonance and optical characteristics (14). Some UCNPs labeled with radionuclide also showed potential for use as trimodality in vivo imaging probes for PET/MR/ optical imaging (15).…”

mentioning

confidence: 99%

RGD Peptide–Conjugated Multimodal NaGdF₄:Yb³⁺/Er³⁺ Nanophosphors for Upconversion Luminescence, MR, and PET Imaging of Tumor Angiogenesis

et al. 2012

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Multimodal nanoparticles have been extensively studied for target-specific imaging and therapy of various diseases, including cancer. In this study, radiolabeled arginine-glycine-aspartic acid (RGD)-functionalized Er 31 /Yb 31 co-doped NaGdF 4 upconversion nanophosphors (UCNPs) were synthesized and evaluated as a multimodal PET/MR/optical probe with tumor angiogenesisspecific targeting properties. Methods: A dimeric cyclic RGDyk ((cRGDyk) 2 ) peptide was conjugated to polyacrylic acid-coated NaGdF 4 :Yb 31 /Er 31 UCNPs along with polyethylene glycol molecules and was consecutively radiolabeled with 124 I. In vitro cytotoxicity testing was performed for 3 d. Upconversion luminescence imaging of (cRGDyk) 2 -UCNP was performed on U87MG cells with a laboratory-made confocal microscope. In vivo small-animal PET and clinical 3-T T1-weighted MR imaging of 124 I-labeled RGD-functionalized UCNPs was acquired with or without blocking of cyclic RGD peptide in a U87MG tumor model. Inductively coupled plasma mass spectrometry and biologic transmission electron microscopy were done to evaluate gadolinium concentration and UCNP localization, respectively. Results: Polymer-coated UCNPs and dimeric RGD-conjugated UCNPs were monodispersely synthesized, and those of hydrodynamic size were 30 6 8 nm and 32 6 9 nm, respectively. (cRGDyk) 2 -UCNPs have a low cytotoxic effect on cells. Upconversion luminescence signals of (cRGDyk) 2 -UCNP were specifically localized on the surface of U87MG cells. 124 I-c(RGDyk) 2 -UCNPs specifically accumulated in U87MG tumors (2.8 6 0.8 vs. 1.3 6 0.4 percentage injected dose per gram in the blocking experiment), and T1-weighted MR images showed significant positive contrast enhancement in U87MG tumors. Tumor localization of 124 I-c(RGDyk) 2 -UCNPs was confirmed by inductively coupled plasma mass spectrometry and biologic transmission electron microscopy analysis. Conclusion: These results suggest that 124 Ilabeled RGD-functionalized UCNPs have high specificity for a v b 3 integrin-expressing U87MG tumor cells and xenografted tumor models. Multimodal UCNPs can be used as a platform nanoparticle with multimodal imaging for cancer-specific diagnoses.

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confidence: 99%

RGD Peptide–Conjugated Multimodal NaGdF₄:Yb³⁺/Er³⁺ Nanophosphors for Upconversion Luminescence, MR, and PET Imaging of Tumor Angiogenesis

et al. 2012

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“…The NIRF of nematodes, mouse tissue, and M1 cells was observed by detecting 1.5-μ m emission from the Er doped in the ceramic phosphor [136] . In the same way, a new generation of 3 + lanthanide NPs of NaYF 4 proved to be the multimodality nanoprobes not only for UCL but also for PET and MR imaging [137] . The presence of Yb 3 + and Er 3 + codoped in the NaYF 4 NPs gave rise to the intense UCL emission in the visible and relaxivity for MRI.…”

Section: Upconverting Nanomaterialsmentioning

confidence: 89%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville

2013

Nanotechnology Reviews

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Abstract:The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in the synthesis protocol and characterization of these materials, whereas toxicological issues are sometimes incomplete. Nanoparticlebased contrast agents (CAs) tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of imaging modalities. The multimodal nanoparticles (NPs) are much more efficient than the conventional molecular-scale CAs. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity, and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides the specific applications for classical imaging (magnetic resonance imaging, positron emission tomography, computed tomography, ultrasound, and photoacoustic imaging), the less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA) are mentioned. The perspectives on the multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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“…Gd 3+ doped UCNPs have been used for T1-MRI [142][143][144]. Moreover, the high X-ray attenuation of Lanthanide elements has been exploited for the use of UCNPs as CT contrast agents [145,146].…”

Section: Upconverting Nanoparticlesmentioning

confidence: 99%

Molecular Imaging with 68Ga Radio-Nanomaterials: Shedding Light on Nanoparticles

et al. 2018

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Abstract:The combination of radioisotopes and nanomaterials is creating a new library of tracers for molecular imaging, exploiting the sensitivity of nuclear imaging techniques and the size-dependent properties of nanomaterials. This new approach is expanding the range of applications, including the possibility of theranostics. Among the many different combinations, the use of 68 Ga as the radioisotope in the radio-nanomaterial is particularly convenient. The physicochemical properties of this isotope allow incorporating it into many materials with great chemical flexibility. Furthermore, its production from a benchtop generator eases the preparation of the tracer. Here, we review main results from the last years in which a nanomaterial has been radiolabeled with 68 Ga. In thus process, we pay attention to the use of nanomaterials for biomedical imaging in general and main properties of this radioisotope. We study the main methods to carry out such radiolabeling and the most important applications for molecular imaging.

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Fluorine-18-labeled Gd3+/Yb3+/Er3+ co-doped NaYF4 nanophosphors for multimodality PET/MR/UCL imaging

Cited by 391 publications

References 38 publications

RGD Peptide–Conjugated Multimodal NaGdF₄:Yb³⁺/Er³⁺ Nanophosphors for Upconversion Luminescence, MR, and PET Imaging of Tumor Angiogenesis

RGD Peptide–Conjugated Multimodal NaGdF₄:Yb³⁺/Er³⁺ Nanophosphors for Upconversion Luminescence, MR, and PET Imaging of Tumor Angiogenesis

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Molecular Imaging with 68Ga Radio-Nanomaterials: Shedding Light on Nanoparticles

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Fluorine-18-labeled Gd3+/Yb3+/Er3+ co-doped NaYF4 nanophosphors for multimodality PET/MR/UCL imaging

Cited by 391 publications

References 38 publications

RGD Peptide–Conjugated Multimodal NaGdF4:Yb3+/Er3+ Nanophosphors for Upconversion Luminescence, MR, and PET Imaging of Tumor Angiogenesis

RGD Peptide–Conjugated Multimodal NaGdF4:Yb3+/Er3+ Nanophosphors for Upconversion Luminescence, MR, and PET Imaging of Tumor Angiogenesis

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Molecular Imaging with 68Ga Radio-Nanomaterials: Shedding Light on Nanoparticles

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RGD Peptide–Conjugated Multimodal NaGdF₄:Yb³⁺/Er³⁺ Nanophosphors for Upconversion Luminescence, MR, and PET Imaging of Tumor Angiogenesis

RGD Peptide–Conjugated Multimodal NaGdF₄:Yb³⁺/Er³⁺ Nanophosphors for Upconversion Luminescence, MR, and PET Imaging of Tumor Angiogenesis