Fluorine-18 labeled rare-earth nanoparticles for positron emission tomography (PET) imaging of sentinel lymph node

Sun, Yun; Yu, Mengxiao; Liang, Sheng; Zhang, Yingjian; Li, Chenguang; Mou, Tiantian; Yang, Wenjiang; Zhang, Xianzhong; Li, Biao; Huang, Chunhui; Li, Fuyou

doi:10.1016/j.biomaterials.2011.01.011

Cited by 182 publications

(134 citation statements)

References 40 publications

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“…Based on the a±nity between Ln 3þ and F À , Sun and coworkers had introduced radioactive 18 F onto the surface of rare-earth nanoparticles, such as oxide,°u oride and hydroxide. 99 The 18 F-labeling process only took 5 min in pure water and the yield of 18 Flabeling was more than 90%. The bio-distribution of 18 F-labeled rare-earth nanoparticles was further investigated by PET imaging.…”

Section: Ucnps For Positron Emission Tomography Imagingmentioning

confidence: 99%

Upconversion nanoparticle as a theranostic agent for tumor imaging and therapy

Fang

Wei

2016

J. Innov. Opt. Health Sci.

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Upconversion nanoparticles (UCNPs) as a promising material are widely studied due to their unique optical properties. The material can be excited by long wavelength light and emit visible wavelength light through multiphoton absorption. This property makes the particles highly attractive candidates for bioimaging and therapy application. This review aims at summarizing the synthesis and modi¯cation of UCNPs, especially the applications of UCNPs as a theranostic agent for tumor imaging and therapy. The biocompatibility and toxicity of UCNPs are also further discussed. Finally, we discuss the challenges and opportunities in the development of UCNP-based nanoplatforms for tumor imaging and therapy.

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Section: Ucnps For Positron Emission Tomography Imagingmentioning

confidence: 99%

Upconversion nanoparticle as a theranostic agent for tumor imaging and therapy

Fang

Wei

2016

J. Innov. Opt. Health Sci.

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“…) and fluoride ions [165]. The 18 F-labeled rare-earth NPs were further evaluated by PET imaging, for their in vivo distribution and their application in lymph monitoring.…”

Section: +mentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

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The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in synthesis protocol and characterization of these materials whereas toxicological issues are sometimes incomplete. Nanoparticle-based contrast agents tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of 2 imaging modalities. Multimodal nanoparticles (NPs) are much more efficient than conventional molecular-scale contrast agents. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides specific applications for classical imaging, (MRI, PET, CT, US, PAI) are also mentioned less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA).Perspectives on multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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“…In light, its short half-life, its quick conjugation into the probe with a high reaction yield, is necessary to improve its efficiency and to reduce cost. A general synthesis strategy for such 18 ) and fluoride ions [165] . The 18 F-labeled rare-earth NPs were further evaluated by PET imaging, for their in vivo distribution and their application in lymph monitoring.…”

Section: Radionuclide Labeled Nanoparticlesmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville

2013

Nanotechnology Reviews

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Abstract:The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in the synthesis protocol and characterization of these materials, whereas toxicological issues are sometimes incomplete. Nanoparticlebased contrast agents (CAs) tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of imaging modalities. The multimodal nanoparticles (NPs) are much more efficient than the conventional molecular-scale CAs. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity, and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides the specific applications for classical imaging (magnetic resonance imaging, positron emission tomography, computed tomography, ultrasound, and photoacoustic imaging), the less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA) are mentioned. The perspectives on the multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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Fluorine-18 labeled rare-earth nanoparticles for positron emission tomography (PET) imaging of sentinel lymph node

Cited by 182 publications

References 40 publications

Upconversion nanoparticle as a theranostic agent for tumor imaging and therapy

Upconversion nanoparticle as a theranostic agent for tumor imaging and therapy

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

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