Fluorine Containing Molecules for Peptidomimicry: A Chemical Act to Modulate Enzymatic Activity

The Trifluoroethylamine Function as Peptide Bond Replacement

“…[21] In conclusion, the trifluoroethylamino function is a very promising peptide-and amide-bond replacement that will likely find extensive application in medicinal chemistry and drug discovery. [22] …”

Peptidomimicry with C2‐Symmetric Oligourea Derivatives of 1,2‐Diaminocyclohexane and 1,2‐Diphenyl‐1,2‐diaminoethane: Chirality and Chain Length‐Dependent Conformation

“…The mimicking of natural peptides, both structurally and functionally, with artificial oligomers is referred to as peptidomimicry . The end products are called peptidomimetics .…”

“…The mimicking of natural peptides, both structurally and functionally, with artificial oligomers is referred to as peptidomimicry. [1][2][3][4][5][6] The end products are called peptidomimetics. [7][8][9] Various strategies, such as cyclization of linear peptides, [10][11][12] replacing the natural amino acids with unnatural ones, [13][14][15][16] substitution of the amide functionality with other functional groups etc., [17] have been applied to construct peptide mimetics.…”