Fluorine substitution enhances the self-assembling ability of hydrogelators

Wu, Chengfan; Zheng, Zhen; Guo, Yuenan; Tian, Chong-Li; Xue, Qiang; Liang, Gaolin

doi:10.1039/c7nr02499a

Cited by 14 publications

(6 citation statements)

References 39 publications

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“…With the radiative transition of 1 I 6 1 D 2 , and 1 G 4 energy levels, the released photons are absorbed by CDs, resulting in afterglow emission. In addition, Wu et al [171] adopted the same strategy to achieve multicolor afterglow under 980 nm excitation by one-step in situ introduction of upconversion luminescence into CDs composites.…”

Section: Radiative Energy Transfermentioning

confidence: 99%

Multicolor Afterglow from Carbon Dots: Preparation and Mechanism

Ran,

Liu,

Zhuang

et al. 2023

Small Methods

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Carbon dots (CDs), as emerging long afterglow luminescent material, have attracted the attention of researchers and become one of the hot topics in long afterglow materials. In recent years, researchers have obtained a series of CDs‐based long afterglow materials with different properties utilizing matrix‐assisted and self‐protective methods. To meet diverse application needs, the development of multicolor CDs‐based long afterglow materials is a focus and challenge in this field. Most of the previously reported CDs‐based long afterglow materials generally emit blue or green afterglow. Recently, some multicolor systems have been discovered, and the emission range can extend from ultraviolet to near‐infrared. However, there is a lack of systematic and in‐depth analysis regarding the preparation strategy and luminescence mechanism of multicolor afterglow from CDs‐based long afterglow materials. Based on this, this review summarizes the preparation strategies of multicolor afterglow from raw materials and reaction parameters. Then, the luminescence mechanisms of multicolor afterglow are analyzed from seven factors, including carbonization degree, surface state, aggregation degree, temperature dependence, excitation dependence, multi‐emission center, and energy transfer. Moreover, the applications of multicolor afterglow from CDs‐based long afterglow materials are introduced. Finally, the problems and challenges in this field are discussed, and the future development directions are analyzed.

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Section: Radiative Energy Transfermentioning

confidence: 99%

Multicolor Afterglow from Carbon Dots: Preparation and Mechanism

Ran,

Liu,

Zhuang

et al. 2023

Small Methods

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“…This work, being the first case of using 19 F NMR/MRI to sense the activity of tyrosine kinase and phosphatase, underscores the importance of incorporating ENS into a dynamic process. In related studies, 356,357 Liang et al also reported the use of liquid-phase scanning tunneling microscopy (L-STM) to directly visualize enzymatic self-assembly/disassembly of nanofibers of an analogue, in which F replaces the CF 3 group in 85.…”

Section: Enzymatic Noncovalent Synthesis In Cell-free Conditionsmentioning

confidence: 99%

Enzymatic Noncovalent Synthesis

et al. 2020

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Enzymatic reactions and noncovalent (i.e., supramolecular) interactions are two fundamental nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process where enzymatic reactions control intermolecular noncovalent interactions for spatial organization of higher-order molecular assemblies that exhibit emergent properties and functions. Like enzymatic covalent synthesis (ECS), in which an enzyme catalyzes the formation of covalent bonds to generate individual molecules, ENS is a unifying theme for understanding the functions, morphologies, and locations of molecular ensembles in cellular environments. This review intends to provide a summary of the works of ENS within the last decade and emphasize ENS for functions. After comparing ECS and ENS, we describe a few representative examples where nature uses ENS, as a rule of life, to create the ensembles of biomacromolecules for emergent properties/functions in a myriad of cellular processes. Then, we focus on ENS of man-made (synthetic) molecules in cell-free conditions, classified by the types of enzymes. After that, we introduce the exploration of ENS of man-made molecules in the context of cells by discussing intercellular, peri/intracellular, and subcellular ENS for cell morphogenesis, molecular imaging, cancer therapy, and other applications. Finally, we provide a perspective on the promises of ENS for developing molecular assemblies/processes for functions. This review aims to be an updated introduction for researchers who are interested in exploring noncovalent synthesis for developing molecular science and technologies to address societal needs.

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“…Their results indicated that the integration of EISA and subcellular targeting processes could synergistically killing cancer cells without acquired drug resistance. Wu et al introduced fluorine substitution to the precursors to enhance their self-assembling ability as well as anticancer capability . However, the therapeutic effect of these agents are still incomparable to the commonly used anticancer drugs.…”

Section: Recent Advances Of In Situ Nanodrug Preparationmentioning

confidence: 99%

“…Wu et al introduced fluorine substitution to the precursors to enhance their self-assembling ability as well as anticancer capability. 48 However, the therapeutic effect of these agents are still incomparable to the commonly used anticancer drugs. Doxorubicin and taxol always show IC 50 values less than 10 μM toward various cancer cell lines.…”

Section: ■ Introductionmentioning

confidence: 99%

Intracellular Peptide Self-Assembly: A Biomimetic Approach for in Situ Nanodrug Preparation

Wei

et al. 2018

Bioconjugate Chem.

Self Cite

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Most nanodrugs are preprepared by encapsulating or loading the drugs with nanocarriers (e.g., dendrimers, liposomes, micelles, and polymeric nanoparticles). However, besides the low bioavailability and fast excretion of the nanodrugs in vivo, nanocarriers often exhibit in vitro and in vivo cytotoxicity, oxidative stress, and inflammation. Self-assembly is a ubiquitous process in biology where it plays important roles and underlies the formation of a wide variety of complex biological structures. Inspired by some cellular nanostructures (e.g., actin filaments, microtubules, vesicles, and micelles) in biological systems which are formed via molecular self-assembly, in recent decades, scientists have utilized self-assembly of oligomeric peptide under specific physiological or pathological environments to in situ construct nanodrugs for lesion-targeted therapies. On one hand, peptide-based nanodrugs always have some excellent intrinsic chemical (specificity, intrinsic bioactivity, biodegradability) and physical (small size, conformation) properties. On the other hand, stimuli-regulated intracellular self-assembly of nanodrugs is quite an efficient way to accumulate the drugs in lesion location and can realize an in situ slow release of the drugs. In this review article, we provided an overview on recent design principles for intracellular peptide self-assembly and illustrate how these principles have been applied for the in situ preparation of nanodrugs at the lesion location. In the last part, we list some challenges underlying this strategy and their possible solutions. Moreover, we envision the future possible theranostic applications of this strategy.

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Fluorine substitution enhances the self-assembling ability of hydrogelators

Cited by 14 publications

References 39 publications

Multicolor Afterglow from Carbon Dots: Preparation and Mechanism

Multicolor Afterglow from Carbon Dots: Preparation and Mechanism

Enzymatic Noncovalent Synthesis

Intracellular Peptide Self-Assembly: A Biomimetic Approach for in Situ Nanodrug Preparation

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