Fluoroquinolones and tetracyclines as growth factors in aquaculture: Increase of biometrical parameters versus emergence of resistant bacteria and residues in meat

Amable, V. I.; Amarilla, María J. Valdéz; Salas, Paula L.; Mendoza, Jorge Arnaldo; Falcón, Sofia Lizardo; Boehringer, S. I.; Sánchez, Sebastian; Guidoli, Marcos Gabriel

doi:10.1016/j.aquaculture.2022.738640

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…In recent research, enrofloxacin is still used in many regions in the world for prophylaxis and treatment of cultured fish diseases; Amable et al [62] used the subtherapeutic doses of enrofloxacin as a growth promotor and prophylactic for Piaractus mesopotamicus fish (the most cultured fish in Argentina), the drug was administrated in feed twice daily for 120 days. No significant difference was observed in drug resistance between the treated and control groups in the intestinal microbiota up to 90 days of the feeding trial.…”

Section: Discussionmentioning

confidence: 99%

Enrofloxacin, Effective Treatment of Pseudomonas aeruginosa and Enterococcus faecalis Infection in Oreochromis niloticus

Aboyadak,

Ali

2024

Microorganisms

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Enrofloxacin is a broad-spectrum synthetic antimicrobial drug widely used in veterinary medicine. The present study aimed to determine the effective enrofloxacin dose for treating Pseudomonas aeruginosa and Enterococcus faecalis infection in Oreochromis niloticus. P. aeruginosa and E. faecalis isolates were verified using selective differential media and biochemically using the Vitek 2 test. Bacterial isolates were virulent for O. niloticus with LD50 equal to 2.03 × 106 and 2.22 × 107 CFU fish−1 for P. aeruginosa and E. faecalis, respectively. Infected fish suffered from decreased feed intake followed by off-food, tail erosion, darkening of the external body surface, exophthalmia, ascites, and loss of escape reflex. Internally, congested hemorrhagic hepatopancreas with engorged distended gall bladder were dominant. The posterior kidney was congested with enlarged spleen, and empty elementary tract. Pathologically, severe degenerative changes were dominant in the hepatopancreas, posterior kidney, spleen, stomach, and gills of infected fish. Antimicrobial sensitivity test indicated the high susceptibility of P. aeruginosa and E. faecalis to enrofloxacin with MIC estimated at 1 and 0.0625 µg/mL, respectively. Enrofloxacin effectively protected O. niloticus against E. faecalis and P. aeruginosa infection when used with medicated feed at doses of 10 and 20 mg kg−1 body weight.

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Section: Discussionmentioning

confidence: 99%

Enrofloxacin, Effective Treatment of Pseudomonas aeruginosa and Enterococcus faecalis Infection in Oreochromis niloticus

Aboyadak,

Ali

2024

Microorganisms

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“…The enhanced production may lead to harmful algal blooms [3]. On the other hand, antibiotics are added into aquaculture ponds, one side for diminishing disease appearance, another for increasing the survival and mean weight of animals [4], while aquaculture ponds polluted by over-used antibiotics are considered to be a notorious source of antibiotic resistance genes (ARGs), which are harmful for the environment and humans and have been recognized as one of the most critical public health concerns of the 21st century by the World Health Organization [5,6]. Xu et al [7] demonstrated that antibiotics significantly changed the microbial composition of the rhizosphere and had a profound effect on the nitrogen and carbon cycling in the microenvironment formed by the plant-microbe system.…”

Section: Introductionmentioning

confidence: 99%

Effects of Different Submerged Macrophytes on the Water and Sediment in Aquaculture Ponds with Enrofloxacin Residues

Zhang

Liu

Zhang

2023

Water

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Submerged macrophyes have been widely used to restore aquaculture ponds in recent years. Yet, whether the residual antibiotics in ponds will affect the remediation effect of submerged macrophyes, and the effect of different submerged macrophyes on the water and sediment in aquaculture ponds with antibiotic residues, is unclear. A microcosm experiment was carried out to study the interaction between three kinds of submerged macrophytes and their growing environment with antibiotic residues. Ceratophyllum demersum L. with no roots, Vallisneria spiralis L. with flourish roots, and Hydrilla verticillata L with little roots were chosen to be planted in the sediment added with enrofloxacin (ENR). The growth of submerged macrophytes, the changes of the overlying water and sediment characteristics, and the microbial community in the sediment were analyzed. The results showed that according to the growth rate and nutrients accumulation ability, V. spiralis with flourish roots performed best among the three submerged macrophytes. The concentrations of TOC, TP, NH4+-N, and TN in the overlying water were 25.0%, 71.7%, 38.1%, and 24.8% lower in the V. spiralis treatment comparing with the control, respectively. The richness and diversity of the microorganisms in the sediment of V. spiralis treatment were significantly higher than those in the control, but this advantage was not obvious in the H. verticillata treatment. V. spiralis promoted the growth of Proteobacteria (22.8%) and inhibited the growth of Acidobacteria (32.1%) and Chloflexi (31.7%) in the rhizosphere sediment with ENR residue. The effects of the three submerged macrophytes on the removal of ENR from sediment were not reflected due to the limitation of water depth. Compared with C. demersum and H. verticillata, V. spiralis was more suitable for the remediation of the aquaculture ponds with ENR residue.

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Occurrence and Health Risks of Antibiotic Resistance in African Aquatic Systems

Gwenzi

Ngaza

Marumure

et al. 2023

Antimicrobial Research and One Health in Africa

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Fluoroquinolones and tetracyclines as growth factors in aquaculture: Increase of biometrical parameters versus emergence of resistant bacteria and residues in meat

Cited by 7 publications

References 12 publications

Enrofloxacin, Effective Treatment of Pseudomonas aeruginosa and Enterococcus faecalis Infection in Oreochromis niloticus

Enrofloxacin, Effective Treatment of Pseudomonas aeruginosa and Enterococcus faecalis Infection in Oreochromis niloticus

Effects of Different Submerged Macrophytes on the Water and Sediment in Aquaculture Ponds with Enrofloxacin Residues

Occurrence and Health Risks of Antibiotic Resistance in African Aquatic Systems

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