Flurbiprofen for the treatment of bone pain in patients with metastatic breast cancer

Lomen, Pavel L.; Samal, Bohumil A.; Lamborn, Kathleen R.; Sattler, Linda P.; Crampton, Sheri L.

doi:10.1016/0002-9343(86)90118-x

Cited by 21 publications

(21 citation statements)

References 4 publications

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“…We screened 5991 publications, of which 43 met the inclusion criteria after full‐text review ( Figure ) . We excluded 30 studies (Supporting Information, S4).…”

Section: Resultsmentioning

confidence: 99%

“…Only two studies focused on a specific primary tumour (breast cancer). The remaining studies included a variety of primary tumours (e.g.…”

Section: Resultsmentioning

confidence: 99%

“…lung, breast, colorectal region, prostate, liver, blood, or skin). Pain due to bone metastases was an inclusion criterion in six studies . Approximately 50% of the studies did not specify the type and location of the pain; the remainder had various origins, for example, visceral, neuropathic, or bone.…”

Section: Resultsmentioning

confidence: 99%

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Systematic review and meta‐analysis on non‐opioid analgesics in palliative medicine

Schüchen

Mücke

Marinova

et al. 2018

J cachexia sarcopenia muscle

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Non‐opioid analgesics are widely used for pain relief in palliative medicine. However, there is a lack of evidence‐based recommendations addressing the efficacy, tolerability, and safety of non‐opioids in this field. A comprehensive systematic review and meta‐analysis on current evidence can provide a basis for sound recommendations in clinical practice. A database search for controlled trials on the use of non‐opioids in adult palliative patients was performed in Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PsycINFO, and EMBASE from inception to 18 February 2018. Endpoints were pain intensity, opioid‐sparing effects, safety, and quality of life. Studies with similar patients, interventions, and outcomes were included in the meta‐analyses. Our systematic search was able to only identify studies dealing with cancer pain. Of 5991 retrieved studies, 43 could be included (n = 2925 patients). There was no convincing evidence for satisfactory pain relief by acetaminophen alone or in combination with strong opioids. We found substantial evidence of moderate quality for a satisfactory pain relief in cancer by non‐steroidal anti‐inflammatory drugs (NSAIDs), flupirtine, and dipyrone compared with placebo or other analgesics. There was no evidence for a superiority of one specific non‐opioid. There was moderate quality of evidence for a similar pain reduction by NSAIDs in the usual dosage range compared with up to 15 mg of morphine or opioids of equianalgesic potency. The combination of NSAID and step III opioids showed a beneficial effect, without a decreased tolerability. There is scarce evidence concerning the combination of NSAIDs with weak opioids. There are no randomized‐controlled studies on the use of non‐opioids in a wide range of end‐stage diseases except for cancer. Non‐steroidal anti‐inflammatory drugs, flupirtine, and dipyrone can be recommended for the treatment of cancer pain either alone or in combination with strong opioids. The use of acetaminophen in the palliative setting cannot be recommended. Studies are not available for long‐term use. There is a lack of evidence regarding pain treatment by non‐opioids in specific cancer entities.

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“…We screened 5991 publications, of which 43 met the inclusion criteria after full‐text review ( Figure ) . We excluded 30 studies (Supporting Information, S4).…”

Section: Resultsmentioning

confidence: 99%

“…Only two studies focused on a specific primary tumour (breast cancer). The remaining studies included a variety of primary tumours (e.g.…”

Section: Resultsmentioning

confidence: 99%

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Systematic review and meta‐analysis on non‐opioid analgesics in palliative medicine

Schüchen

Mücke

Marinova

et al. 2018

J cachexia sarcopenia muscle

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“…16 Flurbiprofen has been shown to possess an adequate analgesic/anti-inflammatory activity in a large number of wellcontrolled studies in rheumatology, gynecology, obstetrics, oncology, and other medical disciplines. [17][18][19][20][21][22] In the present study, the administration of flurbiprofen 100 mg resulted in a significant analgesic activity superior to acetaminophen 500 mg and to placebo in a sample of adult outpatients with moderate to severe postoperative pain following periodontal surgery. These results further support earlier observations with the drug in dental patients given some prior to or after dental surgery.…”

Section: Discussionmentioning

confidence: 90%

Analgesic Efficacy of Flurbiprofen as Compared to Acetaminophen and Placebo After Periodontal Surgery

Gallardo

Rossi²

1990

Journal of Periodontology

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The purpose of the present investigation was to compare the analgesic efficacy of flurbiprofen, a nonsteroidal anti-inflammatory drug, which is a phenyl propionic acid derivative, with acetaminophen and placebo in 63 adult outpatients with moderate to severe dental pain following periodontal surgery. After surgery was completed under local anesthesia, the patients received under double-blind conditions an envelope containing four tablets of either flurbiprofen 100 mg, acetaminophen 500 mg, or placebo and they were instructed to take one tablet every 6 hours when postoperative pain reached moderate to severe intensity. To determine analgesic efficacy and patients recorded pain intensity on a scale of 0 to 3. Patients were allowed to remedicate after 1 hour if pain was not reduced. Flurbiprofen was shown to possess an adequate analgesic effect superior to either placebo (P less than 0.005) or acetaminophen (P less than 0.01) in the parameters studied. Our results seem to further support earlier data obtained with the drug in dental patients with postoperative pain after the surgical removal of impacted third molars; therefore, it is concluded that flurbiprofen used as directed is a new alternative for the proper treatment of pain following periodontal surgery.

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“…Flurbiprofen axetil (2-[3-fluoro-4-biphenyl] propanoic acid) is an NSAID of the propionic acid class and tablets are approved for relief of pain from rheumatoid arthritis and osteoarthritis [32]. Intravenous flurbiprofen axetil is provided as 50 mg ampoules and selectively accumulates at the surgical incision and inflammation sites after administration.…”

Section: Discussionmentioning

confidence: 99%

Intravenous flurbiprofen for post-thymectomy pain relief in patients with myasthenia gravis

Chou

et al. 2012

J Cardiothorac Surg

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BackgroundPost-thymectomy pain in myasthenia gravis (MG) patients can inhibit breathing and coughing. Inappropriate usage of analgesics may exacerbate respiratory inhibition and even cause myasthenic crisis. Flurbiprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used to control moderate postoperative pain and is not associated with respiratory inhibition. We hypothesized that flurbiprofen may provide post-thymectomy pain relief without increasing the risk of complications in MG patients.MethodsTwo hundred MG patients underwent extended thymectomy from March 2006 to December 2010 and were randomly allocated to a flurbiprofen group (110 patients, 50 mg intravenous flurbiprofen axetil) or a control group (90 patients, 100 mg intramuscular tramadol) as postoperative analgesia. Visual analog scale (VAS) pain score, heart rate, blood pressure, respiratory rate, pulse oximetry (SpO2), and adverse effects were recorded before and up to 24 h after drug administration.ResultsThere were no significant differences in the preoperative clinical characteristics of the flurbiprofen and control (tramadol) groups. Both flurbiprofen and tramadol significantly alleviated post-thymectomy pain (p < 0.05 for both), but patients in flurbiprofen group had significantly lower VAS pain scores at 0.5 h, 2 h, 4 h, and 8 h after surgery (p < 0.05 for all times). There were no significant post-thymectomy changes of heart rate, respiratory rate, mean arterial blood pressure, or SpO2 in either group at all time points.ConclusionsPost-thymectomy intravenous administration of flurbiprofen axetil provides safe and effective analgesia for MG patients.

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Flurbiprofen for the treatment of bone pain in patients with metastatic breast cancer

Cited by 21 publications

References 4 publications

Systematic review and meta‐analysis on non‐opioid analgesics in palliative medicine

Systematic review and meta‐analysis on non‐opioid analgesics in palliative medicine

Analgesic Efficacy of Flurbiprofen as Compared to Acetaminophen and Placebo After Periodontal Surgery

Intravenous flurbiprofen for post-thymectomy pain relief in patients with myasthenia gravis

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