Flurbiprofen in the treatment of primary dysmenorrhoea.

Krishna, U.; Naik, S. Vinod; Mandlekar, Ajita; Gupta, Kamini; Kulkarni, V N; Sheth, U K

doi:10.1111/j.1365-2125.1980.tb01087.x

Cited by 10 publications

(21 citation statements)

References 14 publications

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“…A number of placebo-controlled trials have demonstrated that aspirin, given at a dose of 500 to 650 mg four to six times a day, was no more effective than the placebo (34, 90,101,102,104). One study conducted exclusively on adolescent dysmenorrheic subjects, however, found aspirin moderately superior to the placebo in pain relief (105).…”

Section: Aspirinmentioning

confidence: 94%

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Prostaglandins and Nonsteroidal Antiinflammatory Drugs in Dysmenorrhea

Çhan¹

1983

Annu. Rev. Pharmacol. Toxicol.

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INTRODUCTIONDysmenorrhea, commonly known as menstrual pain or cramps, is classifi ed into primary and secondary dysmenorrhea. Generally, primary dysmenorr hea has its inception at the onset of or soon after menarche and characteris tically has no identifiable macroscopical pathology. In contrast, secondary dysmenorrhea usually has its onset in adulthood and is associated with specific pelvic pathology. Some of the causes of secondary dysmenorrhea are endometriosis, uterine polyps, pelvic inflamm atory diseases, uterogeni tal anatomical anomaly, and intrauterine device. Primary dysmenorrhea is by far the more prevalent form.The incidence and prevalence of primary dysmenorrhea have not been established, but it has been estimated that as many as 50% of women of reproductive age, particularly nulliparas, suffer from dysmenorrhea at one time or other. In approximately 10% of these dysmenorrheic subjects, the symptoms are disabling enough to cause incapacitation for one to two days a month (1-4). Primary dysmenorrhea is the most common gynecologic complaint. Because of its cyclic recurring nature, the medical and socioeco nomic impact of dysmenorrhea is enormous. It is the greatest single cause of lost work hours and school days among women (5-8), with more than 140 million work hours estimated to be lost annually (4). With increasing numbers of women entering the work force, dysmenorrhea may cause an even greater economic loss to society. 131Annu. Rev. Pharmacol. Toxicol. 1983.23:131-149. Downloaded from www.annualreviews.org Access provided by University of California -Davis on 02/03/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS 132 CHAN Despite the prevalence of dysmenorrhea, until very recently, medicine has made very little headway either toward the understanding of the patho physiology of dysmenorrhea or the discovery of a specifi c and effective therapy for this female malady. The introduction of oral contraceptives in the 19608 marked the advent of the first effective therapeutic agent for the treatment of primary dysmenorrhea. Oral contraceptives, however, are not specific agents for dysmenorrhea. Until that time, treatments for dys menorrhea were primarily symptomatic, involving strong analgesics, an tidepressants, alcohol, and a variety of home remedies. These therapeutic approaches have not been successful, because of either lack of efficacy or unacceptable side effects. The first rational therapy for dySmenorrhea ap peared on the medical scene as late as the mid 19708, when the relationship between prostaglandin (pG) and dysmenorrhea was recognized and the newer nonsteroidal anti-in1lamm atory drugs (NSAIDs) with PG synthetase inhibitory activity were being introduced to the general medical practice.This review focuses on the etiologic role of PO in primary dysmenorrhea and therapeutic suppression of uterine PG production as a specifi c therapy for dysmenorrhea. PATHOPHYSIOLOGY OF PRIMARY DYSMENORRHEAMany theories have been proposed for the cause of dysmenorrhea. These inc...

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Section: Aspirinmentioning

confidence: 94%

“…One of these, ketoprofen, proved as effective as indomethacin (78). The other, ft urbiprofen, was highly effective in one study (101), while no more so than aspirin in another (102). In a recent study fturbiprofen was found to be as effective as other NSAIDs, but produced a higher incidence of side effects (102a).…”

Section: The Arylpropionic Acidsmentioning

confidence: 94%

Prostaglandins and Nonsteroidal Antiinflammatory Drugs in Dysmenorrhea

Çhan¹

1983

Annu. Rev. Pharmacol. Toxicol.

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“…The eligibility criteria for enrollment were: age between 18 and 40 years, with a regular menstrual cycle (21-35 days), willingness for non-pregnant status during entire study period, at least four painful periods from previous six menses characterized by pain intensity of moderate or severe on verbal rating scale at screening visit. Moderate and severe menstrual pain were defined as per literature [14,15].…”

Section: Inclusion and Exclusion Criteria For Subject Selectionmentioning

confidence: 99%

“…The percentages of a participant who took rescue medication were recorded. Participant's global evaluation of study drug effectiveness was recorded by using a 4-point likert scale (1 = poor, 2 = fair, 3 = good, 4 = excellent) at the end of each treatment period [14,15].…”

Section: Outcome Assessmentmentioning

confidence: 99%

Efficacy and safety of lornoxicam vs ibuprofen in primary dysmenorrhea: a randomized, double-blind, double dummy, active-controlled, cross over study

Patel

Patel²,

Acharya

et al. 2015

European Journal of Obstetrics & Gynecology and Reproductiv

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“…Although aspirin is reported to be effective as an analgesic for menstrual pain when given prophylactically [6,11], it has not been shown to be effective at the onset of menses [10,12,13], However, doses in this study and others may have been less than therapeutic, considering that prescription antiprostaglan dins are commonly given at 2 X starting dos age [11]. Therefore, aspirin (and aspirin-like drugs) cannot be completely ruled out as po tential analgesics for menstrual pain until dosage-response studies are carried out.…”

Section: Discussionmentioning

confidence: 99%

Do Aspirin and Acetaminophen Affect Total Menstrual Loss?

Pendergrass¹,

Ream²,

Scott³

et al. 1984

Gynecol Obstet Invest

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Two commonly taken over-the-counter analgesics, aspirin and acetaminophen, were compared for: effect on total menstrual loss, effect on total days of menstruation, and effect in reduction of pain due to headaches and/or menstrual cramps. Drugs were administered during a 4-month study according to a double-blind format. During the first 2 months, subjects ingested no drugs whatsoever during their menstrual periods. During the second 2 months, subjects ingested aspirin, acetaminophen, or placebo at the rate of two 325-mg tablets every 4 h to total 8 tablets per day during the first 3 days of their menstrual periods. Statistical analysis of the first 2 periods compared to the last 2 showed no differences in total menstrual weights. The number of days of menstruation in the placebo group was significantly lower (p = 0.0137) than in its own control or in the other groups. Neither analgesic showed a signficant reduction in pain due to headache or cramps, although acetaminophen appeared to be slightly more effective than aspirin in reducing menstrual cramps.

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Flurbiprofen in the treatment of primary dysmenorrhoea.

Cited by 10 publications

References 14 publications

Prostaglandins and Nonsteroidal Antiinflammatory Drugs in Dysmenorrhea

Prostaglandins and Nonsteroidal Antiinflammatory Drugs in Dysmenorrhea

Efficacy and safety of lornoxicam vs ibuprofen in primary dysmenorrhea: a randomized, double-blind, double dummy, active-controlled, cross over study

Do Aspirin and Acetaminophen Affect Total Menstrual Loss?

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