Flurbiprofen-loaded acrylate polymer nanosuspensions for ophthalmic application

Pignatello, Rosario; Bucolo, Claudio; Spedalieri, Giancarlo; Maltese, Adriana; Puglisi, Giovanni

doi:10.1016/s0142-9612(02)00080-7

Cited by 238 publications

(132 citation statements)

References 24 publications

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“…Once again this cationic polymeric nanoparticle suspension indicated a controlled drug delivery and high efficiency when compared to the aqueous drug solution [49].…”

Section: -Nsaids Delivery Systemsmentioning

confidence: 71%

Oxaprozin-Loaded Lipid Nanoparticles towards Overcoming NSAIDs Side-Effects

et al. 2015

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“…Once again this cationic polymeric nanoparticle suspension indicated a controlled drug delivery and high efficiency when compared to the aqueous drug solution [49].…”

Section: -Nsaids Delivery Systemsmentioning

confidence: 71%

Oxaprozin-Loaded Lipid Nanoparticles towards Overcoming NSAIDs Side-Effects

et al. 2015

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“…14 Recently, investigations were conducted to develop EDU RS 100 as nanoparticle matrix for the sustained delivery of drugs with a high bioavailability along with good tissue tolerance as shown by the Draiz test in ocular tissues. 15,16 In spite of the good compatibility, few studies have shown that EDU RS 100, a mixture of methacrylate polymers, can be degraded into smaller fragments for absorbance in the eye, and the production process of EDU RS 100 nanoparticles usually requires organic solvents for polymer and drug dissolution and, therefore, it is hard to predict its safety during long-time use. In our study, attempts were made to reduce the amount of EDU RS 100 in the formulation by distributing EDU RS 100 on the surface of the controlled-release and highly biocompatible drug-delivery system-NLC without the use of organic solvents to further reduce any potential toxicity.…”

Section: Zhang Et Almentioning

confidence: 99%

Nanostructured lipid carrier surface modified with Eudragit RS 100 and its potential ophthalmic functions

Zhang¹,

Li²,

Ye³

et al. 2014

IJN

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This study was carried out to evaluate the ocular performance of a cationic Eudragit (EDU) RS 100-coated nanostructured lipid carrier (NLC). The genistein encapsulated NLC (GEN-NLC) was produced using the melt-emulsification technique followed by surface absorption of EDU RS 100. The EDU RS 100 increased the surface zeta potential from −7.46 mV to +13.60 mV, by uniformly forming a spherical coating outside the NLC surface, as shown by transmission electron microscopy images. The EDU RS 100 on the NLC surface effectively improved the NLC stability by inhibiting particle size growth. The obtained EDU RS 100-GEN-NLC showed extended precorneal clearance and a 1.22-fold increase in AUC (area under the curve) compared with the bare NLC in a Gamma scintigraphic evaluation. The EDU RS 100 modification also significantly increased corneal penetration producing a 3.3-fold increase in apparent permeability coefficients (P app ) compared with references. Draize and cytotoxicity testing confirmed that the developed EDU RS 100-GEN-NLC was nonirritant to ocular tissues and nontoxic to corneal cells. These results indicate that the NLC surface modified by EDU RS 100 significantly improves the NLC properties and exhibits many advantages for ocular use.

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“…Other systems that used solvent-or surfactant-based formulations (e.g. microemulsions) or solid dispersions with polyethylene glycol and with polyvinylpyrrolidone required substantial development times and might be limited due to potential excipientrelated toxicity or unwanted effects on the test system (Bettinetti & Mura, 1994;Melani et al, 1995;Mitchell et al, 2003;Mura et al, 2001Mura et al, , 2003Pignatello et al, 2002;Uekama et al, 2006). Upon that, drug-nanotechnology becomes a requirement.…”

Section: Conventional Formulationsmentioning

confidence: 99%