Fluticasone/formoterol dry powder versus budesonide/formoterol in adults and adolescents with uncontrolled or partly controlled asthma

Abstract

ISRCTN60408425).

A valid option for asthma control: Clinical evidence on efficacy and safety of fluticasone propionate/formoterol combination in a single inhaler

“…These two studies were designed to assess non-inferiority of the FP/F combination in comparison with the other comparator combinations used at equivalent doses (Table 3). Both studies showed that the FP/F combination and the comparators had an equivalent effect in term both of pre-dose between-group differences were observed with regards to exacerbation rates and adverse events [26].…”

Inhaled Formoterol-Fluticasone Single Inhaler Therapy in Asthma: Real-World Efficacy, Budget Impact, and Potential to Improve Adherence

“…Many clinical studies have demonstrated the superiority of FF to either component administered as a monotherapy or concurrently via separate inhalers [ 19 , 20 ]. Similarly, the FF combination has been proven to have similar efficacy and safety profiles compared to budesonide/formoterol and fluticasone-salmeterol [ 9 , 21 ]. FF offers an additional benefit of rapid bronchodilation than fluticasone-salmeterol [ 7 , 8 ].…”

An example of using a decision making framework designed for non-medical prescribers as a method for enhancing prescribing safety for inhaled corticosteroids (ICS)

“…The study by Rafferty et al (1985) was a double blinded crossover study which compared between beclomethasone dipropionate (BOP) and budesonide and concluded that there was no difference in their outcomes. Moreover, a recent article in press by Cukier et al (2013) compared between inhaled fluticasone versus budesonide inhalers, both were combined with long acting beta 2 agonist formoterol. The study included adults and adolescents with uncontrolled or partially controlled asthma and the superiority of fluticasone over budesonide was noted in terms of lung function and asthma control.…”