1999
DOI: 10.1046/j.1440-1614.1999.00522.x
|View full text |Cite
|
Sign up to set email alerts
|

Fluvoxamine-Methadone Interaction

Abstract: Clinicians should be aware of the potential for a significant drug interaction between fluvoxamine and methadone.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
13
0

Year Published

2000
2000
2018
2018

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 21 publications
(13 citation statements)
references
References 12 publications
0
13
0
Order By: Relevance
“…Thus, the inhibition of the methadone oxidation pathway by fluvoxamine may lead to severe hypoxaemia and hypercapnia [187]. Conversely, in a different study, a patient unable to maintain an effective methadone concentration despite a dose of 200 mg per day was administered fluvoxamine with subsequent increase in her methadone blood level and reduction of opiate withdrawal symptoms [188].…”
Section: Fluvoxamine: the Paradigm Of Cyp1a2-related Drug Interactionmentioning
confidence: 99%
“…Thus, the inhibition of the methadone oxidation pathway by fluvoxamine may lead to severe hypoxaemia and hypercapnia [187]. Conversely, in a different study, a patient unable to maintain an effective methadone concentration despite a dose of 200 mg per day was administered fluvoxamine with subsequent increase in her methadone blood level and reduction of opiate withdrawal symptoms [188].…”
Section: Fluvoxamine: the Paradigm Of Cyp1a2-related Drug Interactionmentioning
confidence: 99%
“…The serotonin-selective re-uptake inhibitors (SSRI) influence the activity of several cytochrome enzymes [61,62,63]. The CYP1A2 activity is inhibited in declining order of potency by: fluvoxamine, paroxetine, sertraline, fluoxetine, norfluoxetine and nafozadone.…”
Section: Serotonin-selective Re-uptake Inhibitorsmentioning
confidence: 99%
“…SSRI agents co-administered will boost methadone serum levels in rapid metabolizers (i.e. CYP2D6) and have produced toxicity and respiratory arrest when added to a methadone maintenance program [61,62]. Venlafaxine has least potential for drug interaction.…”
Section: Serotonin-selective Re-uptake Inhibitorsmentioning
confidence: 99%
“…This pathway is key to the biotransformation of imipramine, clozapine, olanzapine, tacrine, methadone, caffeine, cyclobenzaprine, haloperidol, and theophylline (Table 2). Fluvoxamine is a potent inhibitor of CYP 1A2 activity [Brosen et al, 1993], and interactions with 1A2 substrates are well documented [Xu et al, 1996;Kuo et al, 1998;Spigset, 1998;Alderman and Frith, 1999;Larsen et al, 1999] The addition of fluvoxamine to steady-state clozapine therapy has caused 5-to 10-fold increases in clozapine plasma concentration [Heeringa et al, 1999] . In our own experience, this interaction can be very potent.…”
Section: Cyp1a2mentioning
confidence: 99%