Fly immunity comes of age: The utility of Drosophila as a model for studying variation in immunosenescence

Corbally, Mary-Kate; Regan, Jennifer C.

doi:10.3389/fragi.2022.1016962

Cited by 3 publications

(1 citation statement)

References 115 publications

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“…Previously, it has been demonstrated that aging in Drosophila is accompanied by a considerable increase in the expression of immune-related genes [ 61 , 62 , 63 ]. In order to assess the effect of Yap/Taz inhibitors on inflammatory markers of aging, we compared the expression level of antimicrobial genes ( Attacin-A ( AttA ), Diptericin A ( DptA ), cecropin A1 ( CecA1 )) between treated and control flies of both sexes at the age of 10 and 20 days.…”

Section: Resultsmentioning

confidence: 99%

Studying the Geroprotective Properties of YAP/TAZ Signaling Inhibitors on Drosophila melanogaster Model

Golubev

Zemskaya

Gorbunova

et al. 2023

IJMS

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The transcriptional coactivators Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are the main downstream effectors of the evolutionarily conserved Hippo signaling pathway. YAP/TAZ are implicated in the transcriptional regulation of target genes that are involved in a wide range of key biological processes affecting tissue homeostasis and play dual roles in the aging process, depending on the cellular and tissue context. The aim of the present study was to investigate whether pharmacological inhibitors of Yap/Taz increase the lifespan of Drosophila melanogaster. Real-time qRT-PCR was performed to measure the changes in the expression of Yki (Yorkie, the Drosophila homolog of YAP/TAZ) target genes. We have revealed a lifespan-increasing effect of YAP/TAZ inhibitors that was mostly associated with decreased expression levels of the wg and E2f1 genes. However, further analysis is required to understand the link between the YAP/TAZ pathway and aging.

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Section: Resultsmentioning

confidence: 99%

Studying the Geroprotective Properties of YAP/TAZ Signaling Inhibitors on Drosophila melanogaster Model

Golubev

Zemskaya

Gorbunova

et al. 2023

IJMS

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Hallmarks of aging: A user’s guide for comparative biologists

Biga,

Duan,

Young

et al. 2025

Ageing Research Reviews

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Timing of starvation determines its effects on susceptibility to infection inDrosophila melanogasterfemales independent of host evolutionary history

Basu,

Singh,

Prasad

2024

Preprint

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An organism's susceptibility to pathogens is contingent on various environmental factors, including the availability of nutrition. Starvation can alter host susceptibility to infections, either directly via depletion of resources essential for proper functioning of the immune system, or indirectly via the various physiological changes it induces within the host body. We tested if the susceptibility of Drosophila melanogaster populations to Enterococcus faecalis infection is affected by (a) whether the hosts are starved before or after the infection, and (b) the evolutionary history of the host. Hosts from laboratory fly populations that have been experimentally evolved to be more resistant to E. faecalis, and their corresponding control populations, were subjected to infection with or without being starved prior to and after being infected. We found that the effect of starvation on susceptibility to E. faecalis changed with the timing of starvation: starvation after infection improved survival of infected hosts, irrespective of how they were treated before infection, while starving only prior to infection (and not after) compromised post-infection survival. The changes in infection susceptibility were uniform in both the evolved and the control populations, suggesting that the effects of starvation are not dependent on pre-existing resistance to the infecting pathogen.

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Fly immunity comes of age: The utility of Drosophila as a model for studying variation in immunosenescence

Cited by 3 publications

References 115 publications

Studying the Geroprotective Properties of YAP/TAZ Signaling Inhibitors on Drosophila melanogaster Model

Studying the Geroprotective Properties of YAP/TAZ Signaling Inhibitors on Drosophila melanogaster Model

Hallmarks of aging: A user’s guide for comparative biologists

Timing of starvation determines its effects on susceptibility to infection inDrosophila melanogasterfemales independent of host evolutionary history

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