FN1 overexpression is correlated with unfavorable prognosis and immune infiltrates in breast cancer

Zhang, Xiuxia; Luo, Junpeng; Wu, Liqiang

doi:10.3389/fgene.2022.913659

Cited by 28 publications

(15 citation statements)

References 56 publications

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“…24 Xiu-Xia Zhang et al pointed out that high expression of FN1 is correlated with poor prognosis and immune infiltrates in breast cancer. 25 FN1 overexpression could promote gastric cancer progression. 26 Herein, miR-200b was found to directly target FN1 in NSCLC cells.…”

Section: Discussionmentioning

confidence: 99%

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Long non‐coding RNA ATB expedites non‐small cell lung cancer progression by the miR‐200b/fibronectin 1 axis

Sun

Zou

et al. 2023

Clinical Laboratory Analysis

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Background Long non‐coding RNA (lncRNA) ATB belongs to an active modulator in multiple cancers, but its expression along with potential underlying non‐small cell lung cancer (NSCLC) is obscure. Our study aimed to investigate the role and potential mechanism of LncRNA ATB in NSCLC. Methods LncRNA ATB expression in NSCLC tissues and cell lines was detected by qRT‐PCR. Effects of LncRNA ATB on NSCLC cell proliferation, migration and invasion were assessed by MTS, colony formation and transwell assays. The connection among LncRNA ATB, miR‐200b and fibronectin 1 (FN1) was determined by bioformatics prediction and luciferase reporter assay. Results In this research, upregulation of LncRNA ATB was discovered in NSCLC tissue samples and cell lines. LncRNA ATB was positively related to advanced tumor phase as well as lymph node metastasis. Cell function assays reflected LncRNA ATB expedited NSCLC cells proliferation, migration and invasion. LncRNA ATB promoted fibronectin 1 (FN1) expression via inhibiting miR‐200b. Furthermore, LncRNA ATB depletion suppressed NSCLC cells proliferation, migration and invasion, while miR‐200b inhibitor or pcDNA‐FN1 rescued these effects. Conclusion In summary, our outcomes elucidated that LncRNA ATB/miR‐200b axis expedited NSCLC cells proliferation, migration and invasion by up‐regulating FN1.

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Section: Discussionmentioning

confidence: 99%

“…In a Mouse Glioma Model, knockdown of FN1 delayed the growth of glioma cells 24 . Xiu‐Xia Zhang et al pointed out that high expression of FN1 is correlated with poor prognosis and immune infiltrates in breast cancer 25 . FN1 overexpression could promote gastric cancer progression 26 .…”

Section: Discussionmentioning

confidence: 99%

Long non‐coding RNA ATB expedites non‐small cell lung cancer progression by the miR‐200b/fibronectin 1 axis

Sun

Zou

et al. 2023

Clinical Laboratory Analysis

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“…LAMA4 deficient mice presented impaired recruitment of neutrophils, monocytes, and lymphocytes to inflammatory loci relative to wild-type mice ( 58 ). FN1 also has been found to be involved in the regulation of innate immune response and to be correlated with immune infiltrates in cancers ( 59 – 61 ). Among the cancer-related proteins, signal transducer and activator of transcription 3 (STAT3) has been well documented to be inflammation and immunity ( 62 – 64 ).…”

Section: Discussionmentioning

confidence: 99%

ITRAQ-based quantitative proteomics analysis of forest musk deer with pneumonia

Tang

Suo²,

Li³

et al. 2022

Front. Vet. Sci.

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Pneumonia can seriously threaten the life of forest musk deer (FMD, an endangered species). To gain a comprehensive understanding of pneumonia pathogenesis in FMD, iTRAQ-based proteomics analysis was performed in diseased (Pne group) lung tissues of FMD that died of pneumonia and normal lung tissues (Ctrl group) of FMD that died from fighting against each other. Results showed that 355 proteins were differentially expressed (fold change ≥ 1.2 and adjusted P-value < 0.05) in Pne vs. Ctrl. GO/KEGG annotation and enrichment analyses showed that dysregulated proteins might play vital roles in bacterial infection and immunity. Given the close association between bacterial infection and pneumonia, 32 dysregulated proteins related to Staphylococcus aureus infection, bacterial invasion of epithelial cells, and pathogenic Escherichia coli infection were screened out. Among these 32 proteins, 13 proteins were mapped to the bovine genome. Given the close phylogenetic relationships of FMD and bovine, the protein-protein interaction networks of the above-mentioned 13 proteins were constructed by the String database. Based on the node degree analysis, 5 potential key proteins related to pneumonia-related bacterial infection in FMD were filtered out. Moreover, 85 dysregulated proteins related to the immune system process were identified given the tight connection between immune dysregulation and pneumonia pathogenesis. Additionally, 12 proteins that might function as crucial players in pneumonia-related immune response in FMD were screened out using the same experimental strategies described above. In conclusion, some vital proteins, biological processes, and pathways in pneumonia development were identified in FMD.

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“…Of the 63 DEGs in monocytes, we generated a signature of 12 overexpressed genes exhibiting immunosuppressive functions and/or associated with a poor cancer prognosis: Cd44 [34], Cd83 [35], Emp1 [36], Eif4e [37], Thbs1 [38], Vegfa [39], Emilin2 [40], Tgm2 [41], Ptgs2 [42], Fn1 [43], Crem [44] , Il1rn [45] (Fig. 5F).…”

Section: By Using Upsetplot Representations To Identify Intersection ...mentioning

confidence: 99%

Therapy-induced senescence drives immunotherapy resistance by inducing an immunosuppressive tumor microenvironment

Beauséjour

Maggiorani

Lê

et al. 2023

Preprint

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Immune checkpoint inhibitors (ICI) invigorate immune cell functions and are effective against many cancer types. However, the potential of ICI may be limited in situations where immune cell fitness is impaired. Here, we show that the efficacy of αPD-L1-based cancer immunotherapies is compromised by the accumulation of senescent cells in mice previously exposed to sublethal irradiation or injected with doxorubicin. Similarly, we observed that the efficacy of the combination of a αCTLA-4 antibody with radiotherapy is diminished in previously irradiated mice. In both models, resistance to immunotherapy was associated with a decrease in the accumulation and activation of CD8 T cells within tumors. Elimination of senescent cells by the injection of the senolytic drug ABT263, weeks before treatments, restored immune homeostasis within the tumor micro-environment (TME) and increased mice survival in both models. Using single-cell transcriptomic analysis, we observed that the injection of ABT263 reverses the exacerbated immunosuppressive profile of myeloid cells in the TME of previously irradiated mice. These myeloid cells, when purified from established tumors, were responsible for impaired CD8 T cell proliferation in vitro. Our study shows that cancer therapies, by inducing senescence, favor the formation of an immunosuppressive TME, which can alter the efficacy of ICI. The use of senolytic drugs before ICI may constitute an interesting pharmacological approach to improve the effectiveness of cancer immunotherapies.

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FN1 overexpression is correlated with unfavorable prognosis and immune infiltrates in breast cancer

Cited by 28 publications

References 56 publications

Long non‐coding RNA ATB expedites non‐small cell lung cancer progression by the miR‐200b/fibronectin 1 axis

Long non‐coding RNA ATB expedites non‐small cell lung cancer progression by the miR‐200b/fibronectin 1 axis

ITRAQ-based quantitative proteomics analysis of forest musk deer with pneumonia

Therapy-induced senescence drives immunotherapy resistance by inducing an immunosuppressive tumor microenvironment

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