Foam-Based Drug Delivery: A Newer Approach for Pharmaceutical Dosage Form

Kumar, Mohit; Thakur, Anil; Mandal, Uttam Kumar; Thakur, Ashish; Bhatia, Amit

doi:10.1208/s12249-022-02390-x

Cited by 19 publications

(8 citation statements)

References 70 publications

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“…These processes replace the injured cells and restore the organ's integrity. [33][34][35] The intricate wound healing system has been divided into four stages: inflammation, proliferation and re-epithelialization, and tissue remodelling. Although these mechanisms try to replace damaged tissue at the wound site, they often result in scarring (particularly in adults).…”

Section: Wound Classificationmentioning

confidence: 99%

“…Liposomes are tiny, spherical synthetic vesicles composed of phospholipids (non-poisonous) and cholesterol. 253,254 Due to their small sizes and hydrophilic and hydrophobic characteristics, liposomes can be used as medication delivery vehicles. Their characteristics are dependent on the lipid content, surface charge, size, and production technique.…”

Section: Liposomesmentioning

confidence: 99%

“…These compounds contribute to the recovery process through a variety of mechanisms, making them advantageous for promoting overall healing and tissue repair. 33,58 For example, in one study, Khan et al investigated the wound-healing potential of Berberis lycium extract. The authors revealed that the prepared polyvinyl alcohol nanofibers loaded with Berberis lycium possess excellent wound healing and antibacterial activity.…”

Section: Introductionmentioning

confidence: 99%

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Nanotechnology-driven wound healing potential of asiaticoside: a comprehensive review

Kumar,

Mahmood

et al. 2024

RSC Pharm.

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Section: Wound Classificationmentioning

confidence: 99%

Section: Liposomesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nanotechnology-driven wound healing potential of asiaticoside: a comprehensive review

Kumar,

Mahmood

et al. 2024

RSC Pharm.

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“…[5,6] Open-cell metal foams are divided into regular and irregular categories based on topology. Open-cell metal foams has applications in weight optimization, topology optimization, [7] drug delivery, [8] bioimplants, [9,10] batteries, [11] catalysts, [12,13] sandwich panels, and reinforcements in composite materials. [14][15][16] The presence of voids in porous materials caused in a huge reduction in terms of weight and relative density and also a decrease in the mechanical characterization of these materials compared to the bulk material.…”

Section: Introductionmentioning

confidence: 99%

Mechanical Response of Open‐Cell Metal Foams with Single‐ and Multilayer Shell during Uniaxial Compression Test

Jalilzadeh,

Rohani Nejad,

Khiabani

et al. 2024

Adv Eng Mater

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Metal foams are one of the unique materials that need more attention in terms of mechanical and microstructural characterizations. In the present study, different kinds of metal foams such as Ni, Cu, and a novel type of multi‐layered metal foams with Ni‐Cu and Cu‐Ni coating layer orders have produced and characterized in terms of mechanical response and microstructure of these novel materials during a uniaxial compression test. These multi‐layered metallic foams have a strong mechanical adhesion at the interface due to the nature of electroforming process and the effect of solid solution area at these interfaces. Besides, Multi‐layered metal foams are superior to Ni and Cu pure metal foams in terms of mechanical response, applying a multi‐layered metallic coat with 60 and 69 μm diameter for Ni and Cu improved the yield point of the Ni and Cu single layer metallic foams for 3 and 7 times, respectively. Moreover, in terms of energy absorption density, the multi‐layered metallic shell has improved the energy absorption density for 3 and 5.5 times compared to Ni and Cu metal foams, respectively. This study shows that applying multi layered coatings to metal foams with Ni as the first layer has superior characteristics compared to single layer metal foams.This article is protected by copyright. All rights reserved.

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“…If this process occurs rapidly, there is no opportunity for the active ingredient to crystallize since the rapid penetration causes a decrease in the concentration of the active ingredient in the foam layer. Furthermore, the linked network of foams allows for effective medication transportation across the epidermal layers, resulting in improved absorption and bioavailability [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Foams Set a New Pace for the Release of Diclofenac Sodium

Falusi,

Berkó,

Budai-Szűcs

et al. 2024

Pharmaceutics

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Medicated foams have emerged as promising alternatives to traditional carrier systems in pharmaceutical research. Their rapid and convenient application allows for effective treatment of extensive or hirsute areas, as well as sensitive or inflamed skin surfaces. Foams possess excellent spreading capabilities on the skin, ensuring immediate drug absorption without the need for intense rubbing. Our research focuses on the comparison of physicochemical and biopharmaceutical properties of three drug delivery systems: foam, the foam bulk liquid, and a conventional hydrogel. During the development of the composition, widely used diclofenac sodium was employed. The safety of the formulae was confirmed through an in vitro cytotoxicity assay. Subsequently, the closed Franz diffusion cell was used to determine drug release and permeation in vitro. Ex vivo Raman spectroscopy was employed to investigate the presence of diclofenac sodium in various skin layers. The obtained results of the foam were compared to the bulk liquid and to a conventional hydrogel. In terms of drug release, the foam showed a rapid release, with 80% of diclofenac released within 30 min. In summary, the investigated foam holds promising potential as an alternative to traditional dermal carrier systems, offering faster drug release and permeation.

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Foam-Based Drug Delivery: A Newer Approach for Pharmaceutical Dosage Form

Cited by 19 publications

References 70 publications

Nanotechnology-driven wound healing potential of asiaticoside: a comprehensive review

Nanotechnology-driven wound healing potential of asiaticoside: a comprehensive review

Mechanical Response of Open‐Cell Metal Foams with Single‐ and Multilayer Shell during Uniaxial Compression Test

Foams Set a New Pace for the Release of Diclofenac Sodium

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