2012
DOI: 10.1515/bmc-2011-0049
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Focal adhesion kinase-regulated signaling events in human cancer

Abstract: Focal adhesion kinase (FAK) is a non-receptor protein tyrosine kinase that is highly expressed or activated in many human cancers. Under specific scenarios, FAK can regulate cell proliferation, cell survival, cell migration and invasion, and has been implicated in the control of tumorigenesis and metastasis. FAK has both catalytic and scaffolding activity, and triggers downstream signals by activation of a number of pathways, including the Ras/mitogen-activated protein kinase pathway, the phosphatidylinositol … Show more

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Cited by 14 publications
(14 citation statements)
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“…However, FAK is overexpressed in most cancers, and it endows cancer cells with functions that normal adult tissue cells do not have, such as the capacity to survive following detachment from the supporting structure. In so doing, FAK becomes a key player in cancer cell metastasis and tissue invasion (Fu et al, 2012;Sulzmaier et al, 2014;Zhang and Hochwald, 2014).…”
Section: Multiple Cellular Functions Of Fakmentioning
confidence: 99%
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“…However, FAK is overexpressed in most cancers, and it endows cancer cells with functions that normal adult tissue cells do not have, such as the capacity to survive following detachment from the supporting structure. In so doing, FAK becomes a key player in cancer cell metastasis and tissue invasion (Fu et al, 2012;Sulzmaier et al, 2014;Zhang and Hochwald, 2014).…”
Section: Multiple Cellular Functions Of Fakmentioning
confidence: 99%
“…for a detailed description. inhibits p53 following cell detachment (Fu et al, 2012;Golubovskaya et al, 2008a;Lim et al, 2008). If focal adhesion contacts are lost, FAK translocates into the nucleus, where it sequesters and inactivates p53 and other pro-apoptotic effectors in a kinase-independent manner, thereby promoting cell survival.…”
Section: Fak In the Nucleusmentioning
confidence: 99%
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“…1 In East Asia, a germline polymorphism of aldehyde dehydrogenase-2, a key enzyme for the elimination of acetaldehyde, is associated with upper aerodigestive tract malignancies, including head and neck SCC (HNSCC). 5,6 FAK functions drive several signaling pathways, which affect tumor phenotypes, includ-ing control of cell survival, motility, invasion, and epithelial-to-mesenchymal transition. 4 Focal adhesion kinase (FAK), encoded by the protein tyrosine kinase 2 gene, is a 125 kDa nonreceptor protein tyrosine kinase located in cellular structures, which are called focal adhesions.…”
Section: Introductionmentioning
confidence: 99%
“…This was demonstrated by the use of the FAK inhibitor II that totally inhibited the effect of sSortilin/NTSR3 on Akt phosphorylation [30]. These findings are crucial since the activation of the FAK pathway is described to be involved in survival mechanisms, and especially in a variety of distinct cancer cell lines’ development and metastasis [41,42]. Indeed, FAK regulates numerous downstream intracellular pathways that mediate either cell migration through actin modification [43] or cell proliferation through transcription factors [44].…”
Section: Signaling Of Ssortilin/ntsr3 In Ht29 Cellsmentioning
confidence: 99%