Focal Dermal Elastosis: A Proposed Update to the Nomenclature

Knapp, Maxwell; Carpenter, Cari E.; Shea, Katelyn; Stowman, Anne M.; Pierson, Joseph C.

doi:10.1097/dad.0000000000001683

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…[6][7][8] The term "focal dermal elastosis" has been proposed as an update of the nomenclature to include also these earlier presentations. 9 However, the cases in younger patients differ also in other clinical features from classic presentation, e.g. association with acrogeria, 6 familiarity, 7 or acral distribution.…”

Section: N O N -C O M M E R C I a L U S E O N L Ymentioning

confidence: 99%

Late-onset focal dermal elastosis: Report of a case and review of the literature

Fantini

Dainese

Recalcati³

2022

Dermatol Reports

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Late-onset focal dermal elastosis is a rare cutaneous condition classified within the disorders of increased dermal elastic tissue. It is characterized clinically by multiple papules with predilection for the neck and other flexures, without systemic alterations, and histologically by focally increased elastic fibers in the reticular dermis. Several elastic tissue disorders share a similar clinical presentation in the skin. Distinction of late-onset focal dermal elastosis and other pseudoxanthoma elasticum mimickers from pseudoxanthoma elasticum is critical, as they are not associated to systemic lesions. We report here on a case of late-onset focal dermal elastosis and review the scientific literature on this unusual condition.

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Section: N O N -C O M M E R C I a L U S E O N L Ymentioning

confidence: 99%

Late-onset focal dermal elastosis: Report of a case and review of the literature

Fantini

Dainese

Recalcati³

2022

Dermatol Reports

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“…There are a variety of clinical manifestations of solar elastosis; most commonly appearing as yellow, thickened, and coarsely wrinkled skin [3]. Solar elastosis and the degeneration of collagen can be observed histologically using hematoxylin and eosin staining (H&E) [4]. These changes are due to an imbalance between the production and degradation of the main proteins produced by fibroblasts [2].…”

Section: Introductionmentioning

confidence: 99%

Impact of Solar Ultraviolet Radiation in the Expression of Type I Collagen in the Dermis

et al. 2021

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Ultraviolet radiation exposure is the dominant environmental determinant of all major forms of skin cancer, and the main cause of prematurely aged skin that is referred to as photoaging. Collagen type I (COL I) is expressed differently along with the dermis between healthy and pathological skin tissues. The aim of this study was to understand the impact of solar radiation in the dermis and assess the impact of solar radiation to COL I. The hematoxylin and eosin staining protocol was performed in tissue paraffin blocks and then they were stained immunohistochemically with the rabbit monoclonal anti-COL I antibody. A total of 270 slides were studied with an Olympus BX 41 microscope; we scored positively the expression of COL I in dermis and statistically analyzed with IBM SPSS Statistics. Based on our results, we observed that solar elastosis changes the structure of the skin’s collagen. In healthy tissues, COL I had a uniform expression along with the dermis. In tissues with aging, COL I expression was weaker and lost homogeneity. In pathological tissues (non-melanoma skin cancers, NMSCs), precancerous lesions, and benign skin lesions), the expression of COL I was observed to be almost weaker than tissues with aging in all body parts and much weaker below the lesions. The most severe solar elastosis was observed in the extremities. The degree of severity of the solar elastosis in relation to age did not appear to be completely affected. Solar radiation divides the collagen more rapidly than normal biological aging and solar elastosis was observed into the skin tissues with photoaging, which replaces the collagen fibers of the skin. These results confirm previous studies, which have shown that skin COL I decreases during aging, more in photoaging and even more in skin cancers. We conclude that skin COL I expression is reduced as a result of ultraviolet radiation and leading to negative impacts on the skin.

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“…Clinically, it usually presents as multiple, small, flat, white to pale yellow papules located on the sides of the neck and flexural areas. 1 , 2 The lesions might be asymptomatic or pruritic and generally occur in the elderly skin. Mainly women are affected.…”

mentioning

confidence: 99%

Late‐onset Focal Dermal Elastosis—dermatoscopic and ultrasonographic assessment of this rare entity and literature review

Korecka,

Czuwara,

Szymoniak‐Lipska

et al. 2023

Skin Research and Technology

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Late-onset Focal Dermal Elastosis-dermatoscopic and ultrasonographic assessment of this rare entity and literature reviewDear Editor, Late Onset Focal Dermal Elastosis (LOFDE) is a rare, acquired cutaneous entity. Clinically, it usually presents as multiple, small, flat, white to pale yellow papules located on the sides of the neck and flexural areas. [1][2] The lesions might be asymptomatic or pruritic and generally occur in the elderly skin. Mainly women are affected. 3 In several reports regarding LOFDE, only a single case was described in a male patient. 4 The histopathological hallmark of LOFDE is the accumulation of the structurally normal elastic tissue in the mid and deep reticular dermis forming conglomerates pushing up collagen bundles. 3 Although LOFDE might clinically resemble pseudoxanthoma elasticum (PXE), their histopathological features differ, and no systemic disorders have been found in this condition. Other differential diagnoses include elastofibroma, papillary dermal elastolysis, nevus elasticus and Buschke-Ollendorff syndrome. 1 The pathogenesis of this entity is not known; however, some theories have been proposed. Since there are no clues of solar elastosis in histopathology, ageing not related to sun damage might have an impact on the appearance of the skin lesions. 3F I G U R E 1 Clinical image of LOFDE: (A) multiple white papules on the right thigh, (B) multiple white papules located unilaterally on the right shin.

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Focal Dermal Elastosis: A Proposed Update to the Nomenclature

Cited by 4 publications

References 5 publications

Late-onset focal dermal elastosis: Report of a case and review of the literature

Late-onset focal dermal elastosis: Report of a case and review of the literature

Impact of Solar Ultraviolet Radiation in the Expression of Type I Collagen in the Dermis

Late‐onset Focal Dermal Elastosis—dermatoscopic and ultrasonographic assessment of this rare entity and literature review

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