Focal Intramedullary Spinal Cord Lesion in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome: Toxoplasmosis Versus Lymphoma

Mohole, Jyodi; Ho, Allen L.; Sussman, Eric S; Pendharkar, Arjun V; Lee, Marco

doi:10.1016/j.wneu.2019.04.057

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…However, there are still some limitations in this study: (1) The number of included literature is small, which may not summarize the research progress in this field well.…”

Section: Discussionmentioning

confidence: 93%

“…However, there are still some limitations in this study: (1) The number of included literature is small, which may not summarise the research progress in this field well. (2) The included literatures are all published research, while high-quality unpublished researches are not included and analysed, which may lead to publication bias.…”

Section: Discussionmentioning

confidence: 93%

“…Human immunodeficiency virus (HIV) infection causes significant damage to the immune function of patients, especially destroying T cells, leading to a significant increase in the incidence of various diseases [ 1 ]. Tuberculosis is a chronic infectious disease with the highest morbidity and mortality in China, which has caused 1.7 million deaths annually [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic value of interferon-γ release assay in HIV-infected individuals complicated with active tuberculosis: a systematic review and meta-analysis

Cao

et al. 2021

Epidemiol. Infect.

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Objective Although the interferon-γ release assay (IGRA) has become a common diagnostic method for tuberculosis, its value in the diagnosis of tuberculosis in human immunodeficiency virus (HIV) seropositive patients remains controversial. Therefore, this systematically reviews the data for exploring the diagnostic value of IGRA in HIV-infected individuals complicated with active tuberculosis, aiming to provide a clinical basis for future clinical diagnosis of the disease. Methods Relevant studies on IGRA for diagnosing tuberculosis in HIV-infected patients were comprehensively collected from Excerpta Medica Database (EMBASE), Medline, Cochrane Library, Chinese Sci-tech Periodical Full-text Database, Chinese Periodical Full-text Database, China National Knowledge Infrastructure (CNKI) and China Wanfang Data up to July 2020. Subsequently, Stata 15.0, an integrated statistical software, was used to analyse the sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (PLR) and negative likelihood ratio (NLR) to create receiver operator characteristic (ROC) curves. Results A total of 18 high-quality articles were selected, including 20 studies, 11 of which were related to QuantiFERON-TB Gold In-Tube (QFT-GIT) and nine to T-SPOT.TB. The meta-analysis indicated that the pooled sensitivity = 0.75 (95% CI 0.63–0.85), the pooled specificity = 0.82 (95% CI 0.66–0.92), PLR = 4.25 (95% CI 1.97–9.18), NLR = 0.30 (95% CI 0.18–0.50), DOR = 14.21 (95% CI 4.38–46.09) and the area under summary ROC curve was 0.85 (95% CI 0.81–0.88). Conclusion IGRA has a good diagnostic value and therefore can aid in the preliminary screening of active tuberculosis in HIV-infected individuals. Its diagnostic effectiveness can be improved by modifying and optimizing the assay design.

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“…However, there are still some limitations in this study: (1) The number of included literature is small, which may not summarize the research progress in this field well.…”

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 93%