Focal ischemia in cat brain as studied by diffusion-weighted and dynamic susceptibility-contrast magnetic resonance imaging

Verheul, H.B.; Tamminga, K.S.; Dijkhuizen, RM; Toorn, van der A Annette; Sprenkel, JW Berkelbach van der; Tulleken, Caf Kees; Nicolaij, K Klaas

doi:10.1007/bf01705274

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…Dit suggereert, dat deze combinatie van diffusie en perfusie MRI-technieken in staat is om drempelwaarden van weefselperfusie, die leiden tot ischemische schade vast te stellen als functie van tijd en locatie. 17,18 Series van dynamische beelden zoals getoond in figuur 5 en figuur 6A-D kunnen worden vertaald naar parametrische beelden, die de ruimtelijke verdeling van diverse hemodynamische parameters representeren. Chemical shift (ppm) The horizontal axis represents a chemical axis while the area under a peak is a measure of the concentration of the corresponding metabolite.…”

Section: Vergunningenunclassified

“…Parametrische beelden van cerebrale hemodynamische indices bij een focaal cerebraal ischemische kat. De dynamische MRI data van figuur 6A-D werden bewerkt tot twee-dimensionale beelden van hemodynamische indices doory-functie fitting van AR 2 *-tijds curves 17. A: Relatieve cerebrale bloedvolume; B: relatieve cerebrale bloedflow index; C: de tijd-tot-de-piek parameter, die de tijd tussen bolus injectie en het tijdstip van maximale FeO concentratie aangeeft; D: de inverse van de maximale AR 2 *.…”

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“…Parametric maps of cerebral hemodynamic indices in a cat with focal cerebral ischemia. The dynamic MRI data of figure 6A-D were converted to two-dimensional maps of hemodynamic indices by yfunktion fitting of AR 2 *-time curves 17. A: Relative cerebral blood volume; B: relative cerebral blood flow index; C: the time-to-peak parameter which indicates the time between bolus injection and the time of maximal FeO concentration; D: the reciprocal of the maximal AR 2 *.…”

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Dynamic magnetic resonance imaging and spectroscopie of experimental brain injury

Nicolay

Dijkhuizen

Toorn

et al. 1996

Acta Neuropsychiatr.

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This article describes the use of non-invasive magnetic resonance (MR) methods for the characterization and monitoring of the pathophysiology of experimental brain injury in laboratory animals as a function of time and treatment. The impact of MR in brain research is primarily due to its non-invasive nature, thereby enabling repeated measurements in long-term studies, and due to the type of information that it provides. MR imaging (MRI) enables the measurement of the morphology/anatomy as well as the functional status of tissues under in vivo conditions. Compared to other in vivo imaging modalities, MRI has a high spatial resolution and allows for a remarkable soft tissue differentiation. MR spectroscopy (MRS) provides information on the biochemical/metabolic status of tissues. MR methods which have proven valuable in animal studies, can be readily translated to the clinical situation where MR-based diagnosis and treatment planning play a rapidly increasing role. After a short introduction into the principles of MR, we will illustrate the remarkable versatility of MR in research on brain injury from recent animal studies. Examples will be mainly drawn from experiments on early injury in focai cerebral ischemia and from research on mechanical brain trauma and excitotoxic lesions. The article ends with a brief description of the perspectives of MR in neuropsychiatry.

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Dynamic magnetic resonance imaging and spectroscopie of experimental brain injury

Nicolay

Dijkhuizen

Toorn

et al. 1996

Acta Neuropsychiatr.

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Ebselen (PZ-51) protects the caudate putamen against hypoxia/ischemia induced neuronal damage

Knollema¹,

Elting²,

Dijkhuizen³

et al. 1996

Neurosci. Res. Comm.

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Ebselen, a synthetic selenium‐containing compound which exhibits glutathione peroxidase‐like activity in vivo, is known for its beneficial effects on inflammation and tissue injury. Experiments were conducted to test whether ebselen dissolved in DiMethylSulfOxide (DMSO) could prevent damage in a rat model for transient unilateral hypoxia/ischemia. Results indicate that ebselen dissolved in DMSO reduced damage in the caudate putamen, the thalamus and the cortex compared to the saline controls. The average damage in the Caudate putamen was also significantly lower in the ebselen group when compared to the DMSO treated rats. Total brain damage in the ebselen group was decreased by 76%. DMSO alone did not reduce damage significantly in any of the analyzed areas. Some protective effects of ebselen, however, may be due to the solvent DMSO. In the caudate putamen ebselen alone was responsible for the observed protection. This protective effect of ebselen might be explained by its actions as a glutathione peroxidase mimic.

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Temporal changes in reversible cerebral ischemia on perfusion- and diffusion-weighted magnetic resonance imaging: the value of relative cerebral blood volume maps

et al. 2002

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Using a transorbital approach we induced the temporal occlusion and reperfusion model in 18 cats. A vascular clamp was placed on the main trunk of the left middle cerebral artery (MCA) for 1 h. Diffusion- and perfusion-weighted MR images were obtained at 1, 3, 6 and 24 h after the clip was released. The cats were killed 24 h after reperfusion, and triphenyl tetrazolium chloride (TTC) staining was performed. After the relative cerebral blood volume (rCBV), time to peak enhancement (TTP) and apparent diffusion coefficient (ADC) maps had been acquired, ROIs were drawn on (1) the area of the infarct produced, (2) the area of high signal intensity on initial diffusion-weighted magnetic resonance imaging (DWI) but normal on TTC staining, e.g., salvaged parenchyma. The ratios of these areas to the normal contralateral cortex were calculated and compared with those of the areas of the final infarct and the salvaged parenchyma. Areas of final infarct showed a temporal increase of rCBV on 3 and 6-h imaging and a final depletion on 24-h imaging. A persistent decrease of ADC value and delayed TTP were observed. Salvaged parenchyma also showed increased rCBV after reperfusion until the last imaging comparing it to the final area of infarct (P< 0.05, 24-h rCBV). The initial decrease in the ADC and delayed TTP normalized on 24-h imaging. In conclusion, rCBV of 24-h imaging was the reliable parameter to predict final infarct. A combination of serial changes on DWI and perfusion-weighted imaging (PWI) can predict ischemic penumbra and outcome.

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Focal ischemia in cat brain as studied by diffusion-weighted and dynamic susceptibility-contrast magnetic resonance imaging

Cited by 5 publications

References 13 publications

Dynamic magnetic resonance imaging and spectroscopie of experimental brain injury

Dynamic magnetic resonance imaging and spectroscopie of experimental brain injury

Ebselen (PZ-51) protects the caudate putamen against hypoxia/ischemia induced neuronal damage

Temporal changes in reversible cerebral ischemia on perfusion- and diffusion-weighted magnetic resonance imaging: the value of relative cerebral blood volume maps

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