Focal lesions within the ventral striato-pallidum abolish attraction for male chemosignals in female mice

Agustín-Pavón, Carmen; Martínez‐Garciá, Fernando; Lanuza, Enrique

doi:10.1016/j.bbr.2013.11.020

Cited by 32 publications

(37 citation statements)

References 34 publications

(14 reference statements)

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“…Some consistencies in the IC localization were uncovered. The IC are hypothesized to be critical for a variety of cognitive and behavioral demands (Heimer, 2003;Inta et al, 2011;Adjei et al, 2013;Agustı´n-Pavo´n et al, 2014). The distribution of the IC in the OT with regard to their location in the three layers of the OT as well as their medial and lateral positioning suggests that the IC do not all similarly receive equal input from the olfactory bulb nor connected brain reward structures.…”

Section: Inter-mouse Variations In the Icmentioning

confidence: 98%

Laminar and spatial localization of the islands of Calleja in mice

Adjei

Wesson

2015

Neuroscience

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Section: Inter-mouse Variations In the Icmentioning

confidence: 98%

Laminar and spatial localization of the islands of Calleja in mice

Adjei

Wesson

2015

Neuroscience

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“…Additionally, immediate early gene studies have shown that opposite-sex (but not same-sex) conspecific body odorants activate several segments of the brain’s reward circuitry including the mOT (unpublished observations), AcbC, AcbSh, and the ventral tegmental area (VTA) [8,11–12]. More recently, electrolytic lesions of the ventral striato-pallidum, a region that includes the mOT, disrupted opposite-sex odor preference in female mice [13], whereas 6-OHDA lesions of the dopamine (DA) fibers innervating the mAcb did not affect this preference [14]. These latter authors suggested that pheromonal reward is DA-independent, which conflicts with earlier studies using in vivo voltammetry and microdialysis techniques showing that exposing male rats to estrous female odors (both volatiles alone and volatiles+nonvolatiles) causes significant increases in DA release from the Acb [15,16].…”

mentioning

confidence: 99%

“…Because of prior studies indicating DA release in the mAcb in response to investigating opposite-sex pheromones, we created one group of subjects with 6-OHDA lesions confined to the mAcb. Given the recently discovered involvement of the mOT in pheromone reinforcement [13], we also created a group of subjects with 6-OHDA lesions centered on the mOT. In this group of subjects, leakage of the neurotoxin almost always spread to the mAcb.…”

mentioning

confidence: 99%

6-Hydroxydopamine lesions of the anteromedial ventral striatum impair opposite-sex urinary odor preference in female mice

DiBenedictis

Olugbemi

Baum

et al. 2014

Behavioural Brain Research

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Rodents rely upon their olfactory system to perceive opposite-sex pheromonal odors needed to motivate courtship behaviors. Volatile and nonvolatile components of pheromonal odors are processed by the main (MOS) and accessory olfactory system (AOS), respectively, with inputs converging in the medial amygdala (Me). The Me in turn targets the mesolimbic dopamine system, including the nucleus accumbens core (AcbC) and shell (AcbSh), the ventral pallidum (VP), medial olfactory tubercle (mOT) and ventral tegmental area (VTA). We hypothesized that pheromone-induced dopamine (DA) release in the ventral striatum (particularly in the mAcb and mOT) may mediate the normal preference of female mice to investigate male pheromones. We made bilateral 6-OHDA lesions of DA fibers innervating either the mAcb alone or the mAcb+mOT in female mice and tested estrous females’ preference for opposite-sex urinary odors. We found that 6-OHDA lesions of either the mAcb alone or the mAcb+mOT significantly reduced the preference of sexually naïve female mice to investigate breeding male urinary odors (volatiles as well as volatiles+nonvolatiles) vs. estrous female urinary odors. These same neurotoxic lesions had no effect on subjects’ ability to discriminate between these two urinary odors, on their locomotor activity, or on their preference for consuming sucrose. The integrity of the dopaminergic innervation of the mAcb and mOT is required for female mice to prefer investigating male pheromones.

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“…In addition, the OT contains medium spiny neurons as principal neurons that receive massive dopaminergic inputs from the midbrain, and constitutes a ventral striatum with the nucleus accumbens 11–13,15–17 . In line with these structural properties, functional studies have supported the notion that the OT is involved in the translation of sensory signals into various motivated behaviours 18–23 .…”

Section: Introductionmentioning

confidence: 67%

“…This study nonetheless offers the basis for further addressing the contribution of the OT domain to the weaning process. Functional manipulation by opto/pharmacogenetics and cell ablation methods which have been successfully adopted also in the adult OT 18–20,23 would reveal the role of the anteromedial OT domain in the weaning. Weaning is a learning process critical for the development of eating behaviours and for the food preference in adolescence and adult.…”

Section: Discussionmentioning

confidence: 99%

Functional development of olfactory tubercle domains during weaning period in mice

Murofushi

Mori

Murata

et al. 2018

Sci Rep

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Mammals shift their feeding habits from mother’s milk to environmental foods postnatally. While this weaning process accompanies the acquisition of attractive behaviour toward environmental foods, the underlying neural mechanism for the acquisition is poorly understood. We previously found that adult mouse olfactory tubercle (OT), which belongs to the olfactory cortex and ventral striatum, has functional domains that represent odour-induced motivated behaviours, and that c-fos induction occurs mainly in the anteromedial domain of OT following learned odour-induced food seeking behaviour. To address the question whether the anteromedial OT domain is involved in the postnatal acquisition of food seeking behaviour, we examined OT development during weaning of mice. Whereas at postnatal day 15 (P15), all mice were attracted to lactating mothers, P21 mice were more attracted to familiar food pellets. Mapping of c-fos induction during food seeking and eating behaviours showed that while c-fos activation was observed across wide OT domains at P15, the preferential activation of c-fos in the anteromedial domain occurred at P21 and later ages. These results indicate that preferential c-fos activation in the anteromedial OT domain occurred concomitantly with the acquisition of attractive behaviour toward food, which suggests the importance of this domain in the weaning process.

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Focal lesions within the ventral striato-pallidum abolish attraction for male chemosignals in female mice

Abstract: Revista:BEHAVIOURAL BRAIN RESEARCH

Cited by 32 publications

References 34 publications

Laminar and spatial localization of the islands of Calleja in mice

Laminar and spatial localization of the islands of Calleja in mice

6-Hydroxydopamine lesions of the anteromedial ventral striatum impair opposite-sex urinary odor preference in female mice

Functional development of olfactory tubercle domains during weaning period in mice

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