Focally amplified lncRNA on chromosome 1 regulates apoptosis of esophageal cancer cells via DRP1 and mitochondrial dynamics

Liu, Tao; Wang, Zhi; Zhou, Riqiang; Liang, Wulin

doi:10.1002/iub.1971

Cited by 15 publications

(7 citation statements)

References 24 publications

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“…1A). In contrast, focally amplified lncRNA on chromosome 1 (FAL1) inhibits apoptosis and cytochrome c release in esophageal squamous cell carcinoma (ESCC) cells by suppressing DRP1, which promotes cancer cell survival and increases mitochondrial respiration [36]. Fis1 can also be targeted by other microRNAs such as miR-483-5p.…”

Section: Lncrnas Regulate Mitochondrial Functionmentioning

confidence: 99%

LncRNAs regulate metabolism in cancer

et al. 2020

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Metabolic reprogramming is a hallmark of cancer. Mammalian genome is characterized by pervasive transcription, generating abundant non-coding RNAs (ncRNAs). Long non-coding RNAs (lncRNAs) are freshly discovered functional ncRNAs exerting extensive regulatory impact through diverse mechanisms. Emerging studies have revealed widespread roles of lncRNAs in the regulation of various cellular activities, including metabolic pathways. In this review, we summarize the latest advances regarding the regulatory roles of lncRNAs in cancer metabolism, particularly their roles in mitochondrial function, glucose, glutamine, and lipid metabolism. Moreover, we discuss the clinical application and challenges of targeting lncRNAs in cancer metabolism. Understanding the complex and special behavior of lncRNAs will allow a better depiction of cancer metabolic networks and permit the development of lncRNA-based clinical therapies by targeting cancer metabolism.

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Section: Lncrnas Regulate Mitochondrial Functionmentioning

confidence: 99%

LncRNAs regulate metabolism in cancer

et al. 2020

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“…For example, inhibition of AK055347 lncRNA was detrimental to cells’ viability that was accompanied by downregulation of ETC, cyt P450, and ATP synthase ( 150 ). Cardiac apoptosis-related lncRNA (CARL) blocked mitochondrial fission and apoptosis by impairing miR-539-dependent PHB2 downregulation ( 151 ), while FAL1 lncRNA enhanced DRP1-mediated mitochondrial fission and apoptosis ( 152 ). GAS5 and SAMMSON lncRNAs are also shown to regulate apoptosis via diverse mechanisms.…”

Section: Non-coding Rna Regulation Of Mitochondrial Health and Its Pomentioning

confidence: 99%

Mitochondrial Regulation of Macrophage Response Against Pathogens

2021

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Innate immune cells play the first line of defense against pathogens. Phagocytosis or invasion by pathogens can affect mitochondrial metabolism in macrophages by diverse mechanisms and shape the macrophage response (proinflammatory vs. immunomodulatory) against pathogens. Besides β-nicotinamide adenine dinucleotide 2'-phosphate, reduced (NADPH) oxidase, mitochondrial electron transport chain complexes release superoxide for direct killing of the pathogen. Mitochondria that are injured are removed by mitophagy, and this process can be critical for regulating macrophage activation. For example, impaired mitophagy can result in cytosolic leakage of mitochondrial DNA (mtDNA) that can lead to activation of cGAS–STING signaling pathway of macrophage proinflammatory response. In this review, we will discuss how metabolism, mtDNA, mitophagy, and cGAS–STING pathway shape the macrophage response to infectious agents.

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“…LncRNAs like Braveheart [ 16 ], Alien [ 17 ], SENCR [ 18 ] and hoxBlinc [ 19 ] are required for cardiac, endoderm, endothelial and hematopoietic differentiation, respectively. A large number of lncRNAs are involved in a variety of cancers, such as ANRIL [ 20 ], CARLo-5 [ 21 ], FAL1 [ 22 ], GAS5 [ 23 ], HOTAIR [ 24 ], HOTTIP [ 25 ], PCGEM1 [ 26 ], PCA3 [ 27 ]. The diversity of lncRNAs and their biological functions are taking giant leap at present.…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility

Joshi

Rajender

2020

Reprod Biol Endocrinol

100

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Background Long non-coding RNAs (lncRNAs) have a size of more than 200 bp and are known to regulate a host of crucial cellular processes like proliferation, differentiation and apoptosis by regulating gene expression. While small noncoding RNAs (ncRNAs) such as miRNAs, siRNAs, Piwi-interacting RNAs have been extensively studied in male germ cell development, the role of lncRNAs in spermatogenesis remains largely unknown. Objective In this article, we have reviewed the biology and role of lncRNAs in spermatogenesis along with the tools available for data analysis. Results and conclusions Till date, three microarray and four RNA-seq studies have been undertaken to identify lncRNAs in mouse testes or germ cells. These studies were done on pre-natal, post-natal, adult testis, and different germ cells to identify lncRNAs regulating spermatogenesis. In case of humans, five RNA-seq studies on different germ cell populations, including two on sperm, were undertaken. We compared three studies on human germ cells to identify common lncRNAs and found 15 lncRNAs (LINC00635, LINC00521, LINC00174, LINC00654, LINC00710, LINC00226, LINC00326, LINC00494, LINC00535, LINC00616, LINC00662, LINC00668, LINC00467, LINC00608, and LINC00658) to show consistent differential expression across these studies. Some of the targets of these lncRNAs included CENPB, FAM98B, GOLGA6 family, RPGR, TPM2, GNB5, KCNQ10T1, TAZ, LIN28A, CDKN2B, CDKN2A, CDKN1A, CDKN1B, CDKN1C, EZH2, SUZ12, VEGFA genes. A lone study on human male infertility identified 9879 differentially expressed lncRNAs with three (lnc32058, lnc09522, and lnc98497) of them showing specific and high expression in immotile sperm in comparison to normal motile sperm. A few lncRNAs (Mrhl, Drm, Spga-lncRNAs, NLC1-C, HongrES2, Tsx, LncRNA-tcam1, Tug1, Tesra, AK015322, Gm2044, and LncRNA033862) have been functionally validated for their roles in spermatogenesis. Apart from rodents and humans, studies on sheep and bull have also identified lncRNAs potentially important for spermatogenesis. A number of these non-coding RNAs are strong candidates for further research on their roles in spermatogenesis.

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Focally amplified lncRNA on chromosome 1 regulates apoptosis of esophageal cancer cells via DRP1 and mitochondrial dynamics

Cited by 15 publications

References 24 publications

LncRNAs regulate metabolism in cancer

LncRNAs regulate metabolism in cancer

Mitochondrial Regulation of Macrophage Response Against Pathogens

Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility

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