Focally enhanced gastritis: A frequent type of gastritis in patients with Crohn's disease

Oberhuber, Georg; Püspök, Andreas; Oesterreicher, C.; Novacek, Gottfried; Zauner, Christian; Burghuber, M; Vogelsang, Harald; Pötzi, R; Stolte, Manfred; Wrba, Friedrich

doi:10.1053/gast.1997.v112.pm9041230

Cited by 241 publications

(166 citation statements)

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“…Microscopic inflammation is, however, considerably more common and may be detected in between 8 and 75% of patients (101,102). Some of the gastritis in these individuals can be attributed to H. pylori infection (10 -33%), but in approximately 50% of individuals, the inflammation is considered to be a direct involvement by Crohn's disease.…”

Section: Gastritis and Duodenitis In Patients With Inflammatory Bowelmentioning

confidence: 99%

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Gastritis and Carditis

Owen

2003

Modern Pathology

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Dyspepsia is a common clinical problem. Its causes include peptic ulcer disease, gastroesophageal reflux, and functional (nonulcer) dyspepsia. A detailed clinical description of pain does not reliably differentiate the cause. Approximately 80% of gastroscopies are performed for the investigation of dyspepsia. "Gastritis" is diagnosed endoscopically in 59% of all stomachs, although in only 3% are the changes severe. Pathologic examination of unselected gastric biopsy specimens reveals that abnormalities are present in 62-73%, but there is only a weak correlation between endoscopic and histologic findings. For these reasons, it is recommended that endoscopic examination should always be accompanied by biopsy. Ideally, biopsies should be taken in a systematic fashion to include sampling of antrum and corpus. Recent evidence suggests that gastric infection by Helicobacter pylori initially presents as a superficial gastritis. Later it may become atrophic with development of intestinal metaplasia. The onset of atrophic changes may be related to the duration of infection, the strain of the infecting organism, associated dietary factors, or as-yet undefined host factors related to immunity. Persistent superficial gastritis predisposes to duodenal ulcer and gastric mucosa-associated lymphoid tissue lymphoma. Atrophic gastritis predisposes to gastric ulcer and adenocarcinoma. Evidence is accumulating that in some patients, pernicious anemia may be an end result of H. pylori-induced atrophic gastritis. Reactive gastropathy is a relatively common finding in gastric biopsies; in most instances it is associated with either reflux of duodenal contents or therapy with nonsteroidal anti-inflammatory drugs. Lymphocytic gastritis, eosinophilic gastritis, and the gastritis associated with Crohn's disease are distinct morphologic entities. Most gastroscopies are performed for the investigation of dyspepsia (1-7). This is a common clinical problem but is rarely life-threatening. The causes of dyspepsia include peptic ulcer disease (30%), gastroesophageal reflux (29%), and nonulcer (functional) dyspepsia (40%). The cause of functional dyspepsia is unclear at the present time, although in many instances it may be related to abnormalities of gut motility. In Ͻ1% of cases is gastric cancer a cause of dyspepsia. A detailed description of the symptoms of dyspepsia does not reliably differentiate the cause, although the presence of heartburn strongly suggests a component of gastroesophageal reflux. Correlations among patient symptoms, endoscopic appearances, and biopsy findings of gastritis are imperfect (4 -6). Agreement is best in cases where peptic ulcer or another focal lesion is identified. A study by Khakoo et al. (7) from the United Kingdom illustrates the problems encountered. Endoscopic and histologic findings were reviewed in 167 patients who underwent gastroscopy for dyspeptic symptoms. Of these, 98 patients (57%) had endoscopic evidence of gastritis. In 42% of patients, gastritis involved the antrum alone, in 7% it involved the...

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Section: Gastritis and Duodenitis In Patients With Inflammatory Bowelmentioning

confidence: 99%

“…20). The lymphocytes are typically CD3 positive and the histiocytes, (101). Focally enhanced gastritis is more frequent in the antral mucosa (48%) than in the corpus mucosa (24%) of patients with upper intestinal Crohn's disease (101).…”

Section: Gastritis and Duodenitis In Patients With Inflammatory Bowelmentioning

confidence: 99%

Gastritis and Carditis

Owen

2003

Modern Pathology

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“…Diffuse CD68/CD68R histiocyte infiltration was observed in the H.pylori positive control group. All of the UC patients, however, were H.pylori negative [23]. In our study, H.pylori positivity was determined in the mucosal biopsies of 41.3% of the CD patients with microaggregates, and 75% of the UC patients with microaggregates.…”

Section: Discussionmentioning

confidence: 55%

Role of Macrophage Microaggregation in the Diagnosis of Inflammatory Colitis

Altunoğlu¹,

Tuncer²,

Erten³

et al. 2014

Ann Clin Anal Med

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“…Sua real prevalência permanece desconhecida, sendo classicamente descrita de 0,5% a 13% dos pacientes (9,10,24,21) ; porém, o avanço dos FIGURA 4 -Estômago de volume aumentado, com resíduos alimentares, distensibilidade do antro reduzida e irregularidade da mucosa FIGURA 5 -Espessamento do pregueado mucoso antral com úlceras aftóides FIGURA 6 -Grande úlcera na segunda porção do duodeno métodos radiológicos e principalmente dos endoscópicos, ocorrido nos últimos anos, permitiu o diagnóstico de formas precoces de DC gastroduodenal, atingindo prevalência de 20% a 76% em alguns estudos (26,35) . Clinicamente se caracteriza por dor epigástrica, náuseas, vômitos e emagrecimento, acometendo pacientes mais jovens que a DC ileocólica e ocorrendo, geralmente, em pacientes com DC distal previamente estabelecida, podendo precedê-la ou se manifestar isoladamente.…”

Section: Discussionunclassified

“…Estudos recentes têm relacionado o achado de gastrite focal Helicobacter pylori negativa como sugestivo de envolvimento gastroduodenal pela DC, ocorrendo em 34% (15) a 76% (26) dos pacientes com DC distal. PARENTE et al (27) , recentemente publicaram estudo comparando os achados endoscópicos e histopatológicos de 141 pacientes com DC conhecida, com 79 pacientes com colite ulcerativa e 141 controles normais encontrando prevalência de gastrite focal Helicobacter pylori negativa em 43%, 12% e 19%, respectivamente, o que foi estatisticamente significativo.…”

Section: Discussionunclassified