Focus of tricholemmal differentiation (tricholemmal carcinoma) within Bowen's disease/carcinoma

Misago, Noriyuki; Toda, Shuji; Nakao, Tomokazu

doi:10.1111/1346-8138.13098

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…Several authors have suggested the possibility of a common origin from a pluripotent epithelial stem cell . In support of this concept, Misago et al recently noted expression of CK19, a marker of stem cells, in a case of BD with trichilemmal differentiation . A report of mucinous differentiation in a benign epidermal lesion, predating reports of BD with adnexal differentiation, is also of interest in this regard .…”

Section: Discussionmentioning

confidence: 93%

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Bowen disease with invasive mucin‐secreting sweat gland differentiation: Report of a case and review of the literature

et al. 2019

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Bowen disease (BD) with divergent adnexal differentiation is a rare composite cutaneous tumor featuring different phenotypic elements. Sebaceous, poroid and trichilemmal invasive components have been described in this setting and very infrequent reports of mucinous glandular differentiation are extant. Clinically, these tumors are not sufficiently distinctive to enable recognition without histopathological evaluation. From a microscopic perspective, care must be taken to exclude a collision tumor as well as other combined cutaneous neoplasms featuring squamous and glandular differentiation. Direct continuity between the two epithelial phenotypes helps to establish the correct diagnosis and generates interesting speculation about the pathogenesis of these and other epithelial skin tumors. We describe a case of BD in continuity with an invasive adenocarcinoma exhibiting mucinous sweat gland differentiation on the face of an elderly man. Details of the case are outlined with the objective of adding to a scant literature on this topic.

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Section: Discussionmentioning

confidence: 93%

“…Rarely, cases of BD yielding an invasive adnexal carcinoma have been reported. These include BD in association with sebaceous, trichilemmal, and poroid neoplasia . Even less frequent are reports of BD associated with invasive apocrine/mucinous glandular differentiation .…”

Section: Introductionmentioning

confidence: 99%

Bowen disease with invasive mucin‐secreting sweat gland differentiation: Report of a case and review of the literature

et al. 2019

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“…There were also cases of TLC with primary cutaneous anaplastic large-cell lymphoma, a ductal eccrine component, nevus sebaceous, or a proliferating trichilemmal cyst ( 9 – 12 ). Some cases were combined with other carcinoma at the lesions, four cases with BCC ( 13 , 14 ), two cases with Bowen’s disease ( 15 , 16 ), and one case with Merkel cell carcinoma ( 17 ).…”

Section: Resultsmentioning

confidence: 99%

Systematic analysis and case series of the diagnosis and management of trichilemmal carcinoma

Sun

Zhang²,

Xiao³

et al. 2023

Front. Oncol.

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BackgroundTrichilemmal carcinoma (TLC) is a rare malignant cutaneous adnexal neoplasm, with no relatively comprehensive research.ObjectiveThe aim of this study is to perform an updated statistical analysis so as to better understand TLC’s epidemiology, clinical features, diagnosis, and treatment.MethodsThe diagnosis and treatment of three TLC cases in our department were summarized. Then, all TLC cases published in the literature were retrieved for a comprehensive analysis, followed by the analysis of global trends and regional distribution, demographic characteristics, clinical features, pathogenesis, histopathological features, and treatment and prognosis of TLC.ResultsOf the 231 cases, the incidence of TLC has shown an upward trend recently, especially in China, in Asia. The susceptible population is men aged 60–80 and women over 80, and the most prone location is head and neck. The phenotype of TLC is not always typical and may be misdiagnosed because of the coexistence of other diseases. There is a linear relationship between the diameter and its duration or thickness. UV, locally present skin lesions, trauma, scarring, organ transplantation, and genetic disorders may trigger the occurrence of TLC. Periodic acid–Schiff staining and CD34, but not Epithelial Membrane Antigen (EMA), were helpful in the diagnosis of TLC. Although effective, surgical excision and Mohs micrographic surgery need further improvement to reduce recurrence of TLC. Carcinoma history is an independent risk factor for TLC recurrence.LimitationsThe limitation of this study is the lack of randomized controlled trial on TLC treatment and recurrence.ConclusionTLC has the possibility of invasive growth and recurrence, especially in patients with longer duration and carcinoma history.

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“…[ 65 ] The various conditions associated with BD are multiple clear cell acanthoma, eccrine poroma, porocarcinoma, porokeratotic-eccrine ostial dermal ductal nevus, extramammary Paget's disease, Merkel cell carcinoma, sebaceous carcinoma, and trichilemmal carcinoma. [ 66 67 68 69 70 71 72 73 ]…”

Section: Demographicsmentioning

confidence: 99%

Bowen's Disease

Palaniappan

Karthikeyan

2022

Indian Dermatology Online Journal

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Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the “lull before the storm,” which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis. Immunohistochemistry, dermoscopy, and reflectance confocal microscopy are the adjuvant modalities used in the diagnosis of BD. The treatment depends on various factors like site, size, immune status, patient's age, esthetic outcome, etc. The available therapeutic modalities include topical chemotherapy, surgical modalities, light-based modalities, and destructive therapies. It requires a combined effort of dermatologist, oncosurgeon, and plastic surgeon to plan and execute the management in various presentations of BD.

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Focus of tricholemmal differentiation (tricholemmal carcinoma) within Bowen's disease/carcinoma

Cited by 5 publications

References 13 publications

Bowen disease with invasive mucin‐secreting sweat gland differentiation: Report of a case and review of the literature

Bowen disease with invasive mucin‐secreting sweat gland differentiation: Report of a case and review of the literature

Systematic analysis and case series of the diagnosis and management of trichilemmal carcinoma

Bowen's Disease

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