Wandering the plateau of the trauma realm, fast and precise treatment is vital for the outcome of polytraumatized patients. When these cannot give their entire medical history, different data sources become significant concerning insights. The priorities are assessment and approach to ensure the airway, breathing, circulation disorder, and exposure to the ABCDE method. Proper airflow is essential, and mechanical ventilation may be needed. The ATLS framework and POCUS are cornerstone tools in modern trauma care, improving the timeliness of diagnosis and treatment. Sepsis is one of the probable complications which need prompt diagnosis and intervention. Healthcare providers have a critical role in patient outcomes with polytrauma. Towards these endeavors, we will knowingly address adopting ATLS framework POCUS integration and a way to sepsis.