Focused Microwave Phased Array Thermotherapy for Ablation of Early-Stage Breast Cancer: Results of Thermal Dose Escalation

Vargas, Hernan I.; Dooley, William C.; Gardner, Rod; Gonzalez, Katherine D.; Venegas, Rose; Heywang‐Köbrunner, Sylvia H.; Fenn, Alan J.

doi:10.1245/aso.2004.03.059

Cited by 103 publications

(58 citation statements)

References 31 publications

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“…With this method, the tumor necrosis is often heterogeneous, and early studies have indicated low success rates for complete ablation at 0%-8%. 18,19 In a more recent clinical trial, this technique showed promise in reducing positive margins at excision and a statistically significant decrease in the size of tumors when combined with neoadjuvant chemotherapy. 20 Complications of skin burns and severe pain were observed, and the prone position for a long duration causes more patient discomfort.…”

Section: Microwave Ablationmentioning

confidence: 99%

Image-Guided Ablation in Breast Cancer Treatment

Roubidoux

Yang

Stafford

2014

Techniques in Vascular and Interventional Radiology

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Section: Microwave Ablationmentioning

confidence: 99%

Image-Guided Ablation in Breast Cancer Treatment

Roubidoux

Yang

Stafford

2014

Techniques in Vascular and Interventional Radiology

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“…Three studies on microwave ablation have been published [23][24][25]. A pilot safety (phase I) study included ten patients with core needle biopsy-proven invasive breast carcinoma (T1-T3 tumors) [23].…”

Section: Microwave Ablationmentioning

confidence: 99%

“…In 68% of the patients, histologic evidence of tumor necrosis was present. Finally, this group published a dose-escalation study [25].…”

Section: Microwave Ablationmentioning

confidence: 99%

High Temperature Hyperthermia in Breast Cancer Treatment

Rubio¹,

Salas²

2013

Hyperthermia

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“…The dielectric constants and the electrical conductivity of the phantom were adjusted with powdered polyethylene and sodium chloride, respectively, to be equivalent of those in real muscle. The size of the phantom was 190×190×(50 or 60) mm 3 . The thickness of the phantom was small compared to that in Ch.…”

Section: Experimental Devices and Setupmentioning

confidence: 99%

“…Hyperthermia using a lower frequency of microwave (e.g., 433 MHz) has been already studied (2) , but it was not combined with phase control. Phase control techniques were demonstrated at 2.45 GHz (3) , but at that frequency, the depth of penetration is too small to be adequate. Our proposal includes the selection of a suitable frequency in the lower microwave region.…”

Section: Introductionmentioning

confidence: 99%

Fundamental Study on Localized Heating in Hyperthermia Using Phase Control of Long-wavelength Microwaves

et al. 2007

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Hyperthermia is expected to be as an effective treatment method that can contribute to improving a cancer patient's quality of life. At present, two frequency ranges are used in hyperthermia. One is relatively low and the other is in the microwave range. However, side effects, such as burns due to heating healthy cells or physical strain caused invasive surgery, remain major burdens for patients. To resolve these problems, we propose the use of a lower microwave frequency with phase control. In this paper, we present the selection of a suitable frequency, a demonstration experiment, and a corresponding numerical analysis using the selected frequency.To determine a suitable frequency, we calculated the distribution of SAR in a one-dimensional system. It was composed of a muscle layer between air layers and had two plane wave sources synchronized with an appropriate phase difference at the edges. We found a desirable frequency range of several hundreds MHz in which a single SAR peak existed in the muscle layer.We performed heating experiments on a tissue-equivalent phantom made from agar using a frequency of 430 MHz. We used a pair of circular patch antennas to irradiate the phantom and produced phase differences between the antennas by changing the length of the feed cables. Figure 1 shows grayscale images of the temperature distributions inside the phantom after microwave irradiation. Here, (a) and (b) correspond to the phase differences of 0 and π, respectively. As Fig. 1(a) shows, a higher temperature region was found in the center of x2-axis shown in the figure, while it is a lower temperature in the same region of Fig. 1(b).We also performed a numerical simulation in three dimensions under the same conditions as the experiment. Figure 2 shows grayscale images of the electric field distributions for almost the same area as in Fig. 1. The regions of larger field amplitude corresponded well to those of a higher temperature in Fig. 1. The detailed analysis of these calculations revealed that the temperature distribution was attributable to the interference between radiated waves. The manipulation of the temperature distribution by phase controlled irradiation of long-wavelength microwaves was demonstrated. Hironori Namiki * * * Non-memberFor the treatment of cancer using hyperthermia, high frequency electromagnetic fields are used to heat the cancer cells. These electromagnetic fields fall into two general frequency ranges, one relatively low, and the other in the microwave range. Both produce some side effects such as the heating of healthy cells or the impact on the body of invasive surgery required to expose deep-lying cells. To reduce these side reactions, the use of lower microwave frequencies with phase control was proposed. In this paper, we present a very basic study to prove the viability of the proposed scheme. This includes the selection of a suitable frequency, demonstration of localized heating using the selected frequency, and a three-dimensional numerical analysis of the electromagnetic fields in...

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Focused Microwave Phased Array Thermotherapy for Ablation of Early-Stage Breast Cancer: Results of Thermal Dose Escalation

Abstract: Thermotherapy causes tumor necrosis and can be performed safely with minimal morbidity. The degree of tumor necrosis is a function of the thermal dose. Future studies will evaluate the impact of high doses of thermotherapy on margin status and complete tumor ablation.

Cited by 103 publications

References 31 publications

Image-Guided Ablation in Breast Cancer Treatment

Image-Guided Ablation in Breast Cancer Treatment

High Temperature Hyperthermia in Breast Cancer Treatment

Fundamental Study on Localized Heating in Hyperthermia Using Phase Control of Long-wavelength Microwaves

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