Focused ultrasound-induced stimulation of microbubbles augments site-targeted engraftment of mesenchymal stem cells after acute myocardial infarction

Ghanem, Alexander; Steingen, Caroline; Brenig, Florian; Funcke, Fabienne; Bai, Zikui; Hall, Christopher S.; Chin, Chien Ting; Nickenig, Georg; Bloch, Wilhelm; Tiemann, Klaus

doi:10.1016/j.yjmcc.2009.06.008

Cited by 70 publications

(59 citation statements)

References 26 publications

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“…Because ultrasound contrast agents can be used to image the blood pool, URDDS have been investigated as targeted therapy to the vasculature, including thrombolysis, 114 lithotripsy, 115 chemotherapy, 116 anti-inflammatory treatment, 117 stem cell transplantation 118,119 and gene therapy for coronary heart disease. In recent years, some researchers have started investigating URDDS as therapy targeted to the brain.…”

Section: Targeted Therapy For Vascular Diseasementioning

confidence: 99%

Potential and problems in ultrasound-responsive drug delivery systems

Zhao¹,

Du²,

Lu³

et al. 2013

IJN

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Abstract:Ultrasound is an important local stimulus for triggering drug release at the target tissue. Ultrasound-responsive drug delivery systems (URDDS) have become an important research focus in targeted therapy. URDDS include many different formulations, such as microbubbles, nanobubbles, nanodroplets, liposomes, emulsions, and micelles. Drugs that can be loaded into URDDS include small molecules, biomacromolecules, and inorganic substances. Fields of clinical application include anticancer therapy, treatment of ischemic myocardium, induction of an immune response, cartilage tissue engineering, transdermal drug delivery, treatment of Huntington's disease, thrombolysis, and disruption of the blood-brain barrier. This review focuses on recent advances in URDDS, and discusses their formulations, clinical application, and problems, as well as a perspective on their potential use in the future.

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Section: Targeted Therapy For Vascular Diseasementioning

confidence: 99%

Potential and problems in ultrasound-responsive drug delivery systems

Zhao¹,

Du²,

Lu³

et al. 2013

IJN

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“…Most studies involve pDNA, associated with a microbubble [47] or co-administred [48,49] with them. Due to its negative electrostatic loading pDNA will not penetrate into cells, but if it is located near a microbubble imploding in the vicinity of a cell it may profit from the temporal permeablization of the cell membrane (sonoporation) [50].…”

Section: Large Therapeutic Moleculesmentioning

confidence: 99%

“…Recently, several research groups have shown that a combination of microbubbles and ultrasound [82][83][84] or focused ultrasound only [48] can be applied to enhance the migration or extravasation of stem cells. This is particularly interesting to enhance the homing of mesenchymal stem cells to ischemic heart tissue.…”

Section: Stem Cell Therapymentioning

confidence: 99%

Crucial factors and emerging concepts in ultrasound-triggered drug delivery

Geers

Dewitte

Smedt

et al. 2012

Journal of Controlled Release

113

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“…Promising protocols for preconditioning the host tissue include: low-energy shock waves that have improved EPC recruitment in a hind-limb ischemia model by stimulating the expression of chemoattractants [83]; ultrasound-mediated destruction of microbubbles in the coronary circulation, which improves the recruitment of mononucleated BMC and MSC after transvascular delivery, probably by creating capillary pores [84,85]; extracorporal shock wave treatment in combination with intracoronary transfer of mononucleated BMC, that is already undergoing clinical testing in patients with ischemic heart failure in the Cellwave trial [86].…”

Section: Pre-treatment Of the Host Tissuementioning

confidence: 99%

Cardiac Cell Therapy: The Next (Re)Generation

Forte

Chimenti

Barile

et al. 2011

Stem Cell Rev and Rep

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Heart failure remains one of the main causes of morbidity and mortality in the Western world. Current therapies for myocardial infarction are mostly aimed at blocking the progression of the disease, preventing detrimental cardiac remodeling and potentiating the function of the surviving tissue. In the last decade, great interest has arisen from the possibility to regenerate lost tissue by using cells as a therapeutic tool. Different cell types have been tested in animal models, including bone marrow-derived cells, myoblasts, endogenous cardiac stem cells, embryonic cells and induced pluripotent stem cells. After the conflicting and often inconsistent results of the first clinical trials, a step backward needs to be performed, to understand the basic biological mechanisms underlying spontaneous and induced cardiac regeneration. Current studies aim at finding new strategies to enhance cellular homing, survival and differentiation in order to improve the overall outcome of cellular cardiomyoplasty.

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Focused ultrasound-induced stimulation of microbubbles augments site-targeted engraftment of mesenchymal stem cells after acute myocardial infarction

Cited by 70 publications

References 26 publications

Potential and problems in ultrasound-responsive drug delivery systems

Potential and problems in ultrasound-responsive drug delivery systems

Crucial factors and emerging concepts in ultrasound-triggered drug delivery

Cardiac Cell Therapy: The Next (Re)Generation

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