Focusing neurovisceral integration: Cognition, heart rate variability, and cerebral blood flow

Jennings, J. Richard; Allen, Ben; Gianaros, Peter J.; Thayer, Julian F.; Manuck, Stephen B.

doi:10.1111/psyp.12319

Cited by 99 publications

(91 citation statements)

References 55 publications

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“…However, it is consistent with a recent investigation of HRV and executive functioning using MIDUS II data (Kimhy et al, 2013), which likewise reported that significant relationships between a multifaceted EF factor and various HRV measures were reduced to nonsignificance by the addition of demographic covariates (age, sex, education). It is also consistent with a recent investigation of relationships between regional cerebral blood flow (rCBF), resting HF-HRV, and performance on a battery of seven EF measures (Jennings et al, 2014). This study reported significant associations between HRV and rCBF in several brain areas related to vagal control yet found no relationship of HRV to EF performance or to EF–rCBF associations.…”

Section: Discussionsupporting

confidence: 90%

Integrating affective and cognitive correlates of heart rate variability: A structural equation modeling approach

Mann

Selby

Bates

et al. 2015

International Journal of Psychophysiology

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High frequency heart rate variability (HRV) is a measure of neurocardiac communication thought to reflect predominantly parasympathetic cardiac regulation. Low HRV has been associated empirically with clinical and subclinical levels of anxiety and depression and, more recently, high levels of HRV have been associated with better performance on some measures of executive functioning (EF). These findings have offered support for theories proposing HRV as an index measure of a broad, self-regulatory capacity underlying aspects of emotion regulation and executive control. This study sought to test that proposition by using a structural equation modeling approach to examine the relationships of HRV to negative affect (NA) and EF in a large sample of U.S. adults ages 30s–80s. HRV was modeled as a predictor of an NA factor (self-reported trait anxiety and depression symptoms) and an EF factor (performance on three neuropsychological tests tapping facets of executive abilities). Alternative models also were tested to determine the utility of HRV for predicting NA and EF, with and without statistical control of demographic and health-related covariates. In the initial structural model, HRV showed a significant positive relationship to EF and a nonsignificant relationship to NA. In a covariate-adjusted model, HRV’s associations with both constructs were nonsignificant. Age emerged as the only significant predictor of NA and EF in the final model, showing inverse relationships to both. Findings may reflect population and methodological differences from prior research; they also suggest refinements to the interpretations of earlier findings and theoretical claims regarding HRV.

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Section: Discussionsupporting

confidence: 90%

Integrating affective and cognitive correlates of heart rate variability: A structural equation modeling approach

Mann

Selby

Bates

et al. 2015

International Journal of Psychophysiology

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“…We did not find any fasting-induced HF-HRV changes, which could explain the improved cognitive performance observed and its relationship with executive and nonexecutive fasting-induced changes (see Jennings et al [8] for review). In a previous study reported by Crippa et al [40], it was observed that the injection of acetylcholine into the prefrontal cortex of rats mediated a hypotensive response.…”

Section: Discussionmentioning

confidence: 62%

“…Recent years have shown growing interest in the association between autonomic cardiovascular function and the brain [8, 9] and in the observation that resting heart rate variability (HRV) as a marker of cardiovascular autonomic function [10] can reflect the activity of flexible and integrative neural networks allowing maximal organism accommodation in the face of rapidly changing environmental demands [9]. It has been suggested that there is a relationship between the vagally mediated high-frequency- (HF-) HRV and cognitive functioning (specifically with prefrontal-cortex-related tasks) [8] and between HF-HRV and mood [11, 12].…”

Section: Introductionmentioning

confidence: 99%

“…It has been suggested that there is a relationship between the vagally mediated high-frequency- (HF-) HRV and cognitive functioning (specifically with prefrontal-cortex-related tasks) [8] and between HF-HRV and mood [11, 12]. A recent study reported that 48 h fasting decreased HRV; however, the HF component of HRV was not affected [3]; thus, it can be expected that 48 h fasting would not affect mood and cognition.…”

Section: Introductionmentioning

confidence: 99%

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Effect of 48 h Fasting on Autonomic Function, Brain Activity, Cognition, and Mood in Amateur Weight Lifters

Solianik

Sujeta

Terentjevienė

et al. 2016

BioMed Research International

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Objectives. The acute fasting-induced cardiovascular autonomic response and its effect on cognition and mood remain debatable. Thus, the main purpose of this study was to estimate the effect of a 48 h, zero-calorie diet on autonomic function, brain activity, cognition, and mood in amateur weight lifters. Methods. Nine participants completed a 48 h, zero-calorie diet program. Cardiovascular autonomic function, resting frontal brain activity, cognitive performance, and mood were evaluated before and after fasting. Results. Fasting decreased (p < 0.05) weight, heart rate, and systolic blood pressure, whereas no changes were evident regarding any of the measured heart rate variability indices. Fasting decreased (p < 0.05) the concentration of oxygenated hemoglobin and improved (p < 0.05) mental flexibility and shifting set, whereas no changes were observed in working memory, visuospatial discrimination, and spatial orientation ability. Fasting also increased (p < 0.05) anger, whereas other mood states were not affected by it. Conclusions. 48 h fasting resulted in higher parasympathetic activity and decreased resting frontal brain activity, increased anger, and improved prefrontal-cortex-related cognitive functions, such as mental flexibility and set shifting, in amateur weight lifters. In contrast, hippocampus-related cognitive functions were not affected by it.

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“…One participant was missing depressive symptom scores. Although we have published neuroimaging findings from AHAB-II (Allen, Jennings, Gianaros, Thayer, & Manuck, 2015; Gianaros et al, 2014; Jennings, Allen, Gianaros, Thayer, & Manuck, 2015; Jennings et al, 2016; Marsland et al, 2015), the current findings are the first bearing on resting-state connectivity and inflammation in this sample.…”

Section: Methodsmentioning

confidence: 67%

Systemic inflammation and resting state connectivity of the default mode network

Marsland

Kuan

Sheu

et al. 2017

Brain, Behavior, and Immunity

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101

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The default mode network (DMN) encompasses brain systems that exhibit coherent neural activity at rest. DMN brain systems have been implicated in diverse social, cognitive, and affective processes, as well as risk for forms of dementia and psychiatric disorders that associate with systemic inflammation. Areas of the anterior cingulate cortex (ACC) and surrounding medial prefrontal cortex (mPFC) within the DMN have been implicated specifically in regulating autonomic and neuroendocrine processes that relate to systemic inflammation via bidirectional signaling mechanisms. However, it is still unclear whether indicators of inflammation relate directly to coherent resting state activity of the ACC, mPFC, or other areas within the DMN. Accordingly, we tested whether plasma interleukin (IL)-6, an indicator of systemic inflammation, covaried with resting-state functional connectivity of the DMN among 98 adults aged 30–54 (39% male; 81% Caucasian). Independent component analyses were applied to resting state fMRI data to generate DMN connectivity maps. Voxel-wise regression analyses were then used to test for associations between IL-6 and DMN connectivity across individuals, controlling for age, sex, body mass index, and fMRI signal motion. Within the DMN, IL-6 covaried positively with connectivity of the sub-genual ACC and negatively with a region of the dorsal medial PFC at corrected statistical thresholds. These novel findings offer evidence for a unique association between a marker of systemic inflammation (IL-6) and ACC and mPFC functional connectivity within the DMN, a network that may be important for linking aspects of immune function to psychological and behavioral states in health and disease.

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Focusing neurovisceral integration: Cognition, heart rate variability, and cerebral blood flow

Cited by 99 publications

References 55 publications

Integrating affective and cognitive correlates of heart rate variability: A structural equation modeling approach

Integrating affective and cognitive correlates of heart rate variability: A structural equation modeling approach

Effect of 48 h Fasting on Autonomic Function, Brain Activity, Cognition, and Mood in Amateur Weight Lifters

Systemic inflammation and resting state connectivity of the default mode network

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