Foetal and Placental Weights in Relation to Maternal Characteristics in Gestational Diabetes

Taricco, Emanuela; Radaelli, Tatjana; Santis, M. S. Nobile De; Cetin, Irene

doi:10.1053/plac.2002.0913

Cited by 155 publications

(114 citation statements)

References 13 publications

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“…Concentrations of leptin in human cord blood correlate with placental size. This is in agreement with the role of leptin in regulating placental growth, which potentially leads to placental hypertrophy under conditions of leptin overproduction, such as the placenta of women with gestational diabetes (GDM) [99,100]. Increased leptin and LEPR expression in placenta from GDM patients have been well described [86,101].…”

Section: Role Of Leptin In Placentationsupporting

confidence: 79%

“…This may be relevant in gestational diabetes [6,86,112,127], a state of greater insulin resistance and hyperinsulinemia than normal pregnancies. In this line, numerous studies have reported that circulating leptin levels, as well as placental leptin and LEPR expression are significantly higher in pregnant women with GDM compared to healthy control women with uncomplicated pregnancy [128,129], providing, at least, a molecular mechanism for the placenta overgrowth previously observed in GDM [99,100]. Others common complications of pregnancy, such as type 1 diabetes mellitus (T1DM) and preeclampsia are also associated with an increase in the concentration of leptin in the maternal blood as well as an increase in placental leptin gene expression [130,131].…”

Section: Role Of Leptin In Pregnancymentioning

confidence: 86%

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Role of leptin in female reproduction

Pérez-Pérez

Sánchez-Jiménez

Maymó

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

127

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Abstract:Reproductive function is dependent on energy resources. The role of weight, body composition, fat distribution and the effect of diet have been largely investigated in experimental female animals as well as in women. Any alteration in diet and/or weight may induce abnormalities in timing of sexual maturation and fertility. However, the cellular mechanisms involved in the fine coordination of energy balance and reproduction are largely unknown. The brain and hypothalamic structures receive endocrine and/or metabolic signals providing information on the nutritional status and the degree of fat stores. Adipose tissue acts both as a store of energy and as an active endocrine organ, secreting a large number of biologically important molecules termed adipokines. Adipokines have been shown to be involved in regulation of the reproductive functions. The first adipokine described was leptin. Extensive research over the last 10 years has shown that leptin is not only an adipose tissue-derived messenger of the amount of energy stores to the brain, but also a crucial hormone/cytokine for a number of diverse physiological processes, such as inflammation, angiogenesis, hematopoiesis, immune function, and most importantly, reproduction. Leptin plays an integral role in the normal physiology of the reproductive system with complex interactions at all levels of the hypothalamic-pituitary gonadal (HPG) axis. In addition, leptin is also produced by placenta, where it plays an important autocrine function. Observational studies have demonstrated that states of leptin excess, deficiency, or resistance can be associated with abnormal reproductive function. This review focuses on the leptin action in female reproduction.

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Section: Role Of Leptin In Placentationsupporting

confidence: 79%

Section: Role Of Leptin In Pregnancymentioning

confidence: 86%

Role of leptin in female reproduction

Pérez-Pérez

Sánchez-Jiménez

Maymó

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

127

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“…However, both in diet controlled and drug controlled cases of GDM were also found to deliver with large placentas and macrosomic babies [25,26]. The increased baby weight as found in the present study may be one of the consequence of the placental weight and also intrinsic placental dysregulation factors such as glucose transport during pregnancy [27] which is statistically related by strong association with one another and is concordant with other authors [28,29].…”

Section: Control (N=48) Range (Mini-maxi) Gdm (N=48) Range (Mini-maxisupporting

confidence: 91%

Gross Morphological Study of Gestational Diabetes Mellitus Placenta From South Indian Mothers Compared With Control Placenta

P¹,

K²,

Kiran³

et al. 2017

IJAR

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“…However, maternal hyperinsulinemia might increase transplacental glucose transport to the fetus (378). Maternal hyperinsulinemia and hyperglycemia could thus cause fetal hyperglycemia with attendant hyperinsulinemia (235) and later increases in fetal weight in offspring of mothers with gestational diabetes (511). On the other hand, insulin clearly does cross the gut wall in the early postnatal development in rodents (213,349) such that elevations in maternal milk insulin levels can be absorbed by the offspring as potential mediators of obesity development in later life (176).…”

Section: Insulinmentioning

confidence: 99%

Gene-Environment Interactions Controlling Energy and Glucose Homeostasis and the Developmental Origins of Obesity

Bouret

Levin

Ozanne

2015

Physiological Reviews

143

103

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LBouret S, Levin BE, Ozanne SE. Gene-Environment Interactions Controlling Energy and Glucose Homeostasis and the Developmental Origins of Obesity. Physiol Rev 95: 47-82, 2015; doi:10.1152/physrev.00007.2014.-Obesity and type 2 diabetes mellitus (T2DM) often occur together and affect a growing number of individuals in both the developed and developing worlds. Both are associated with a number of other serious illnesses that lead to increased rates of mortality. There is likely a polygenic mode of inheritance underlying both disorders, but it has become increasingly clear that the pre-and postnatal environments play critical roles in pushing predisposed individuals over the edge into a disease state. This review focuses on the many genetic and environmental variables that interact to cause predisposed individuals to become obese and diabetic. The brain and its interactions with the external and internal environment are a major focus given the prominent role these interactions play in the regulation of energy and glucose homeostasis in health and disease.

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Foetal and Placental Weights in Relation to Maternal Characteristics in Gestational Diabetes

Cited by 155 publications

References 13 publications

Role of leptin in female reproduction

Role of leptin in female reproduction

Gross Morphological Study of Gestational Diabetes Mellitus Placenta From South Indian Mothers Compared With Control Placenta

Gene-Environment Interactions Controlling Energy and Glucose Homeostasis and the Developmental Origins of Obesity

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