Foetal umbilical cord brain-derived neurotrophic factor (BDNF) levels in pregnancy with gestational diabetes mellitus

Bayman, Melike Geyik; İnal, Zeynep Öztürk; Hayiroglu, Fatih; Öztürk, Elif; Gezginç, Kazım

doi:10.1080/01443615.2021.2006159

Cited by 9 publications

(5 citation statements)

References 18 publications

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“…In contrast to our findings, Bayman et al [35] found higher BDNF levels in n = 20 cord blood samples of mothers with iGDM, but no difference between cord blood levels of all diabetic vs. non-diabetic samples (n = 43 vs. n = 53). The difference may be attributed to differences between the groups, e.g., BMI, degree of obesity, gestational age, mode of delivery, and maternal age.…”

Section: Neonatal Bdnf In Umbilical Cord Bloodcontrasting

confidence: 99%

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Brain-Derived Neurotrophic Factor in Gestational Diabetes: Analysis of Maternal Serum and Cord Blood Pairs and Comparison of Dietary- and Insulin-Dependent GDM

et al. 2022

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The Objective of our study was to investigate the influence of dietary (dGDM) and insulin-dependent (iGDM) gestational diabetes (GDM) on BDNF blood levels of corresponding maternal-neonatal pairs and compare them to pregnancies unaffected by GDM. Blood samples from 293 maternal-neonatal pairs were analyzed. Statistical analysis was performed using multiple regression analysis for association of log-transformed maternal and neonatal BDNF levels in relation to GDM, gestational age, neonatal sex, and mode of delivery. This was followed by a 2:1 matching of healthy and diabetic pairs. Maternal and neonatal BDNF levels were lowest in the iGDM group, followed by the dGDM group and healthy controls (maternal: healthy 665 ± 562 (26–2343) pg/mL vs. dGDM 593 ± 446 (25–1522) pg/mL vs. iGDM 541 ± 446 (68–2184) pg/mL; neonate: healthy 541 ± 464 (9.5–2802) pg/mL vs. dGDM 375 ± 342 (1–1491) pg/mL vs. iGDM 330 ± 326 (47–1384) pg/mL). After multiple regression analysis and additional 2:1 matching neonatal log-BDNF was significantly lower (−152.05 pg/mL, p = 0.027) in neonates of mothers with GDM compared to healthy pairs; maternal log-BDNF was also lower (−79.6 pg/mL), but did not reach significance. Our study is the first to analyze BDNF in matched maternal-neonatal pairs of GDM patients compared to a metabolically unaffected control group.

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Section: Neonatal Bdnf In Umbilical Cord Bloodcontrasting

confidence: 99%

“…Studies on the influence of GDM on fetal and maternal blood BDNF levels are rare, characterized by small numbers, or analyzed by either mother or fetus or placenta [28][29][30][31][32][33][34][35]. Our data are complementary to previously published results and show an inverse correlation between hyperglycemia and BDNF concentration.…”

Section: Bdnf In Gdmsupporting

confidence: 82%

Brain-Derived Neurotrophic Factor in Gestational Diabetes: Analysis of Maternal Serum and Cord Blood Pairs and Comparison of Dietary- and Insulin-Dependent GDM

et al. 2022

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“…reported decreased BDNF levels in fetuses exposed to gestational diabetes, with BDNF concentrations being higher in girls than boys, potentially reflecting the incidence of neurodevelopmental disorders in male infants ( 127 ). In contrast, a recent prospective study investigating umbilical cord BDNF levels in pregnancies complicated by GDM found no differences between the GDM and control groups ( 128 ). Interestingly, reduced BDNF levels were observed in a small number of infants born to diabetic mothers at 12 months of age, and these lower levels were closely associated with impaired language development ( 129 ).…”

Section: Maternal Diabetes and The Fetal Brainmentioning

confidence: 76%

The impact of maternal diabetes on the future health and neurodevelopment of the offspring: a review of the evidence

et al. 2023

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Maternal health during gestational period is undoubtedly critical in shaping optimal fetal development and future health of the offspring. Gestational diabetes mellitus is a metabolic disorder occurring in pregnancy with an alarming increasing incidence worldwide during recent years. Over the years, there is a growing body of evidence that uncontrolled maternal hyperglycaemia during pregnancy can potentially have detrimental effect on the neurodevelopment of the offspring. Both human and animal data have linked maternal diabetes with motor and cognitive impairment, as well as autism spectrum disorders, attention deficit hyperactivity disorder, learning abilities and psychiatric disorders. This review presents the available data from current literature investigating the relationship between maternal diabetes and offspring neurodevelopmental impairment. Moreover, possible mechanisms accounting for the detrimental effects of maternal diabetes on fetal brain like fetal neuroinflammation, iron deficiency, epigenetic alterations, disordered lipid metabolism and structural brain abnormalities are also highlighted. On the basis of the evidence demonstrated in the literature, it is mandatory that hyperglycaemia during pregnancy will be optimally controlled and the impact of maternal diabetes on offspring neurodevelopment will be more thoroughly investigated.

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“…Also, an increase in mitochondrial DNA levels, but dysfunctional syncytiotrophoblast mitochondria with morphological abnormalities [142], has been observed in the placenta of obese pregnant women who developed GDM. These physical abnormalities could lead to impaired pregnancy outcomes and future hypertensive [143,144] and neurological disorders [145]. Additional abbreviations: GDF, growth differentiation factor-15; GSR, glutathione reductase; IGFBP2, insulin-like growth factor-binding protein 2; MGO, methylglyoxal; MVP, mean platelet volume; NLR, neutrophil to lymphocyte ratio; PAF, platelet-activating factor; PCT, procalcitonin; PLR, platelet to lymphocyte ratio; PON, paraoxonase; PPARα, peroxisome proliferator-activated receptors; SIRT1, silent mating type information regulation 2 homolog; UCP2, uncoupling protein 2; VAP-1, vascular adhesion protein-1.…”

Section: Gestational Diabetes Mellitusmentioning

confidence: 99%

Inflammation and Oxidative Stress Induced by Obesity, Gestational Diabetes, and Preeclampsia in Pregnancy: Role of High-Density Lipoproteins as Vectors for Bioactive Compounds

Jiménez-Osorio,

Carreón-Torres,

Correa-Solís

et al. 2023

Antioxidants

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Inflammation and oxidative stress are essential components in a myriad of pathogenic entities that lead to metabolic and chronic diseases. Moreover, inflammation in its different phases is necessary for the initiation and maintenance of a healthy pregnancy. Therefore, an equilibrium between a necessary/pathologic level of inflammation and oxidative stress during pregnancy is needed to avoid disease development. High-density lipoproteins (HDL) are important for a healthy pregnancy and a good neonatal outcome. Their role in fetal development during challenging situations is vital for maintaining the equilibrium. However, in certain conditions, such as obesity, diabetes, and other cardiovascular diseases, it has been observed that HDL loses its protective properties, becoming dysfunctional. Bioactive compounds have been widely studied as mediators of inflammation and oxidative stress in different diseases, but their mechanisms of action are still unknown. Nonetheless, these agents, which are obtained from functional foods, increase the concentration of HDL, TRC, and antioxidant activity. Therefore, this review first summarizes several mechanisms of HDL participation in the equilibrium between inflammation and oxidative stress. Second, it gives an insight into how HDL may act as a vector for bioactive compounds. Third, it describes the relationships between the inflammation process in pregnancy and HDL activity. Consequently, different databases were used, including MEDLINE, PubMed, and Scopus, where scientific articles published in the English language up to 2023 were identified.

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Foetal umbilical cord brain-derived neurotrophic factor (BDNF) levels in pregnancy with gestational diabetes mellitus

Cited by 9 publications

References 18 publications

Brain-Derived Neurotrophic Factor in Gestational Diabetes: Analysis of Maternal Serum and Cord Blood Pairs and Comparison of Dietary- and Insulin-Dependent GDM

Brain-Derived Neurotrophic Factor in Gestational Diabetes: Analysis of Maternal Serum and Cord Blood Pairs and Comparison of Dietary- and Insulin-Dependent GDM

The impact of maternal diabetes on the future health and neurodevelopment of the offspring: a review of the evidence

Inflammation and Oxidative Stress Induced by Obesity, Gestational Diabetes, and Preeclampsia in Pregnancy: Role of High-Density Lipoproteins as Vectors for Bioactive Compounds

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